Sodium Chloride-Vial - instructions for use, dose, side effects, contraindications

0.9% solution of sodium chloride is isotonic with human plasma, and therefore it is rapidly excreted from the vascular bed, only temporarily increasing the volume of circulating blood (effectiveness with blood loss and shock is insufficient).

Pharmacokinetics:

The concentration of sodium ions is 142 mmol / l (plasma) and 145 mmol / l (interstitial fluid), the chloride concentration is 101 mmol / l (interstitial fluid). It is excreted by the kidneys.

Indications:

Disorders of water and electrolyte balance in hypochloraemic alkalosis; hypochloremia; short-term plasma-substitution therapy; hypotonic dehydration; isotonic dehydration.

Contraindications:

Hypernatremia, acidosis, hyperchloremia, hypokalemia, extracellular hyperhydration; circulatory disorders, threatening edema of the brain and lungs, cerebral edema, pulmonary edema, acute left ventricular failure, concomitant administration of glucocorticosteroids in large doses.

Carefully:

Decompensated chronic heart failure, chronic renal failure (oligo-, anuria).

Pregnancy and lactation:

Isotonic sodium chloride solution can be used for indications during pregnancy and during lactation.

Dosing and Administration:

Intravenously drip.

Before administration, the solution is heated to 36-38 ° C.

The dose is determined depending on the loss of body fluids, sodium and chloride ions and an average of 1 l / day. With large losses of fluid and severe intoxication, administration up to 3 l / day is possible. The rate of administration is 540 ml / h, if necessary, the rate of administration is increased.

Children with a marked decrease in blood pressure on the background of dehydration (before determining the laboratory parameters) are administered 20-30 ml / kg. In the future, the dosage regimen is adjusted depending on the laboratory parameters. With long-term administration of large doses of isotonic sodium chloride solution, it is necessary to monitor the acid-base state and electrolytes in blood plasma and urine.

Side effects:

Acidosis, hyperhydration, hypokalemia.

Overdose:

Symptoms: nausea, vomiting, diarrhea, abdominal cramps, thirst, reduced saliva and tear, increased sweating, fever, tachycardia, increased blood pressure, kidney failure,peripheral edema, pulmonary edema, respiratory arrest, headache, dizziness, anxiety, irritability, weakness, muscle cramps and rehydration, generalized convulsions, coma and death. Excessive administration of an isotonic solution of sodium chloride can cause hypernatremia. Excessive intake of chloride into the body can lead to hyperchloremic acidosis. If isotonic sodium chloride solution is used as a base solution for the dilution and transport of other drugs, symptoms and complaints with excessive administration are most often associated with the properties of the drugs added to the solution. In case of unintended excess solution administration, treatment should be discontinued and the patient's condition assessed.

Treatment: symptomatic.

Interaction:

Compatible with colloid hemodynamic blood substitutes (mutual enhancement of the effect).

When mixed with other drugs, it is necessary to visually control the pharmaceutical compatibility.

Special instructions:

With caution apply large amounts of sodium chloride in patients with impaired renal excretion, with hypokalemia.

Effect on the ability to drive transp. cf. and fur:

The use of the drug does not affect the management of vehicles and mechanisms.

Form release / dosage:Solution for infusions, 0,9%.

Packaging:

For 200 or 400 ml in bottles of polypropylene. The bottles are hermetically sealed with polypropylene stoppers with a polyethylene gasket equipped with a device for monitoring the first opening. A label is attached to each bottle.

1 bottle of 200 ml or 1 bottle of 400 ml, along with instructions for use, are placed in a cardboard pack.

For hospitals:

40 bottles of 200 ml and 30 ml of 400 ml with an equal number of instructions for use are placed in boxes of cardboard corrugated.

Storage conditions:

Store at a temperature not exceeding 25 ° C.

Keep out of the reach of children.

Shelf life:

3 years.

Do not use after the expiration date.

Terms of leave from pharmacies:On prescription

Registration number:LP-002144

Date of registration:15.07.2013 / 31.03.2014

Expiration Date:15.07.2018

The owner of the registration certificate:VIAL, LLC VIAL, LLC Russia

Manufacturer: & nbsp

HEBEI TIANCHENG PHARMACEUTICAL, Co., Ltd China

Representation: & nbspVIAL, LLCVIAL, LLC

Information update date: & nbsp16.06.2018

Illustrated instructions

Instructions

Sodium Chloride-Vial (Sodium chloride-Vial)