Sodium chloride - instructions for use, dose, side effects, contraindications

Has a detoxifying and rehydrating effect. Replenishes sodium deficiency in various pathological conditions of the body. A 0.9% solution of sodium chloride is isotonic with human blood plasma, so it is quickly removed from the vascular bed, only temporarily increases the volume of fluid circulating in the vessels.

Pharmacokinetics:

The concentration of sodium is 142 mmol / l (plasma) and 145 mmol / l (interstitial fluid), chloride concentration - 101 mmol / l (interstitial fluid). Excretion by the kidneys.

Indications:Plasmo-isotonic fluid replacement, hypochloraemic alkalosis, hyponatremia with dehydration, intestinal obstruction, intoxications, washing of wounds, eyes, nasal mucosa, dissolution and dilution of medicinal preparations, moisturizing the dressing.

Contraindications:

Hypernatremia, acidosis, hyperchloremia, hypokalemia, extracellular hyperhydration, intracellular dehydration, circulatory disorders threatening edema of the brain and lungs, cerebral edema, pulmonary edema, acute left ventricular failure, concomitant therapy with corticosteroids in large doses.

Carefully:Decompensated chronic heart failure, chronic renal failure (oligoanuria).

Dosing and Administration:

It is administered intravenously by drop, subcutaneous, intramuscular, rectal and external.

Before administration, the preparation should be heated to 36-38 ° C.

The average dose of 1000 ml per day as an intravenous continuous drop infusion at a rate of administration up to 180 drops / min. With large losses of fluid and with intoxication (toxic dyspepsia, cholera), it is possible to administer up to 3000 ml per day. Long-term administration of large doses of isotonic sodium chloride solution is desirable to be carried out under the control of laboratory studies.

Children with shock dehydration (without the definition of laboratory parameters are administered 20-30 ml / kg.) In the future, the dosage regimen is adjusted depending on the laboratory parameters.

Side effects:

Acidosis, hyperhydration, hypokalemia.

Overdose:

The introduction of large volumes of 0.9% sodium chloride solution can lead to chloride acidosis and hyperhydration. In case of an overdose, the drug should be withdrawn and symptomatic therapy should be performed. When hyperhydration, to conduct therapy with osmotic diuretics. In severe heart failure, edema can be eliminated by dialysis.

Interaction:

Compatible with colloidal hemolinic blood substitutes (mutual enhancement of the effect). When adding other drugs to the solution, it is necessary to visually check compatibility.

Special instructions:

The drug should be carefully dose in the case of heart failure, arterial hypertension, impaired renal function, pulmonary edema and peripheral edema, and toxicosis of pregnant women.

It is forbidden to perform an infusion if the solution is opaque or the packaging is damaged.

Form release / dosage:

Solution for infusion 0.9%.

Packaging:In polymer containers of 100, 250, 500, 1000 ml of 70, 32, 20 or 10 pieces respectively in a box of corrugated paper with 3-5 instructions for use (for hospitals).

Storage conditions:

Store in a place protected from light and inaccessible to children at a temperature of no higher than 25 ° C. Freezing of the drug during transportation (provided the container is tight) is not a contraindication to its use. After freezing, keep the containers in the shipping container at room temperature until completely thawed, before shaking, mix the solution in the container with shaking.

Shelf life:

2 years. Do not use after the expiration date.

Terms of leave from pharmacies:On prescription

Registration number:P N000772 / 01

Date of registration:09.06.2008

Expiration Date:Unlimited

The owner of the registration certificate:RESTER, CJSC RESTER, CJSC Russia

Manufacturer: & nbsp

RESTER, CJSC Russia

Information update date: & nbsp16.06.2018

Illustrated instructions

Instructions

Sodium chloride (Sodium chloride)