Inside, with meals or immediately after eating, with a glass of water.The drug should be taken as early as possible with the first signs of the disease. The dosage regimen is set individually, depending on the severity of the disease and the degree of immunosuppression. The duration of prophylactic use of Acyclostad® in patients with varying degrees of immunosuppression, especially in severe immunodeficient conditions, is determined by the time period during which there is a risk of developing a herpes infection.
Infections of the skin and mucous membranes caused by Herpes simplex I and II types. Adults and children over 5 years with a normal immune status, the drug is prescribed 200 mg 4 times a day for 5 days, with a 4-hour interval during the day and with an 8-hour interval overnight. In severe cases, as prescribed by the doctor, the course of treatment can be extended.
Herpes simplex skin and mucous membranes in patients with immunodeficiency (treatment): 200-400 mg 5 times a day for 10 days.
Herpes simplex skin and mucous membranes (prevention): 200 mg 4 times a day, every 6 hours; or 400 mg every 12 hours. In a number of cases, low doses of acyclovir are effective: 200 mg three times a day (every 8 hours) or twice a day (every 12 hours). The course of treatment - individually (see above).
Relapse prevention Herpes simplex in patients with immunodeficiency: 200 mg 4 times a day every 6 hours. In case of severe immunodeficiency (after transplantation bone marrow or with a violation of absorption from the intestine) - 400 mg 5 times a day. The course of treatment - individually (see above).
Genital herpes: Primary infection - 200 mg every 4 hours during wakefulness, 5 times a day for 10 days;
recurrent genital herpes (less than 6 episodes a year), intermittent therapy - 200 mg every 4 hours during wakefulness, 5 times a day for 5 days;
recurrent genital herpes (more than 6 episodes a year), prolonged suppressive therapy - 400 mg twice a day or 200 mg 3 - 5 times a day. Course treatment - up to 12 months. At the end of the course, i.е. After 1 year of suppressive therapy, an assessment should be made of the patient's condition and the appropriateness of continuing treatment with Acyclostad®.
Shingles (herpes): 800 mg every 4 hours during wakefulness, 5 times a day for 7-10 days.
Chickenpox: 800 mg 4 times a day, for 5 days. Children a single dose is calculated at 20 mg / kg, but not more than 800 mg. Children weighing 40 kg or more are prescribed a dose for adults.
Heavy immunodeficiency conditions (as part of combination therapy): 800 mg 4 times a day (every 6 hours).The course of treatment - individually (see above).
When chronic renal failure correction of the dosing regimen is required.
| Recommended mode dosing with normal kidney function | Clearance creatinine (ml / min / 1.73 m2) | Recommended dosing regimen for chronic renal failure |
|
|
| single dose of acyclovir | interval between doses, multiplicity of reception |
| 200 mg every 4 hours | >10 | 200 | every 4 hours - 5 times a day |
|
| 0-10 | 200 | every 12 hours, 2 times a day |
| 400 mg every 12 hours | >10 | 400 | every 12 hours, 2 times a day |
|
| 0-10 | 200 | every 12 hours, 2 times a day |
| 800 mg every 4 hours | >25 | 800 | every 4 hours, 5 times a day |
|
| 10-25 | 800 | every 8 hours, 3 times a day |
|
| 0-10 | 800 | every 12 hours, 2 times a day |
After hemodialysis lasting 6 hours, the concentration of acyclovir in the blood decreases by 60%. In this connection, after each hemodialysis, the patient needs an additional single dose of acyclovir.