Acyclovir - instructions for use, dose, side effects, contraindications

Acyclovir is active against Herpes simplex 1 and 2 types, virus Varicella zoster, the Epstein-Barr virus and cytomegalovirus. Thymidine kinase virus-infected cells through a series of consecutive reactions actively converts acyclovir in mono-, di- and triphosphate of acyclovir. The latter interacts with the viral DNA polymerase and is embedded in DNA, which is synthesized for new viruses. Thus, "defective" viral DNA is formed, which leads to suppression of replication of new generations of viruses.

Pharmacokinetics:

When applying the ointment on intact skin, the absorption is minimal; acyclovir and its metabolites are not determined in blood and urine. With the affected skin, moderate absorption, in patients with normal renal function, the concentration in the serum is up to 0.28 μg / ml, in patients with chronic renal insufficiency up to 0.78 μg / ml.

Indications:

Skin infections caused by the virus Herpes simplex 1 and 2 types, including herpes lips, local treatment of cutaneous mucous manifestations (not life-threatening) of shingles in immunocompromised individuals.

Contraindications:

Hypersensitivity to acyclovir and other components of the drug.

Carefully:With caution, persons under 18 years of age.Efficacy and safety of use in children is not established.

Pregnancy and lactation:

Adequate and controlled clinical trials have not been conducted to ensure safe use of the drug during pregnancy and lactation. The application is shown only when the intended benefit to the mother exceeds the potential risk to the fetus or the baby.

Dosing and Administration:

Outwardly. Ointment is recommended to be applied 6 times a day (approximately every 3 hours) in a thin layer on the affected and adjacent areas of the skin.

Duration of treatment is not less than 5 days. In the absence of healing, treatment can be continued up to 10 days. If the symptoms persist for more than 10 days or if the symptoms worsen significantly, you should consult your doctor.

Side effects:

Possible short-term redness, itching, flaking, burning or tingling in the areas of application. In very rare cases, the development of allergic dermatitis, more often associated with the reaction to auxiliary substances.

Postmarketing experience: swelling and / or pain at the site of application, rash.

Overdose:

If you randomly take the drug inside, the following symptoms are possible: headache, neurological disorders, shortness of breath, nausea, vomiting, diarrhea, impaired renal function, lethargy, convulsions, coma.

Treatment: maintenance of vital functions, hemodialysis.

Interaction:

With external application, no interaction with other drugs has been identified.

Special instructions:

To achieve maximum therapeutic effect, it is necessary to start using the drug already at the first signs of the disease (burning, itching, tingling, sensation of tension and redness).

Patients with immunodeficiency states in the treatment Infectious diseases should be followed by the doctor's recommendations.

Ointment is applied with a cotton swab, or with clean hands to avoid additional infection of affected areas. After applying the ointment is recommended to wash your hands.

Acyclovir in the form of an ointment does not prevent the transmission of infection to another

a person, and also does not prevent recurrence of herpes; when applied in the absence of manifestations of the disease.

Form release / dosage:Ointment for external use 5%.

Packaging:

5 grams per tube aluminum.Each tube together with the instruction for use is placed in a pack of cardboard box.

Storage conditions:

In a dry, dark place at a temperature of no higher than 25 FROM.

Keep out of the reach of children.

Shelf life:

3 years. Do not use after expiry date.

Terms of leave from pharmacies:Without recipe

Registration number:LSR-008889/09

Date of registration:05.11.2009

The owner of the registration certificate:BELMEDPREPARATY, RUP BELMEDPREPARATY, RUP Republic of Belarus

Manufacturer: & nbsp

BELMEDPREPARATY, RUP Republic of Belarus

Information update date: & nbsp12.08.2013

Illustrated instructions

Instructions

Acyclovir (Aciclovir)