Fertility
Information about the effect of Zovirax, tablets or Zovirax preparation, lyophilizate for the preparation of a solution for infusions on female fertility is absent. In a study involving 20 male patients with a normal number of spermatozoa, it was demonstrated that ingestion acyclovir in doses up to 1 g per day up to 6 months does not have a clinically significant effect on the number of spermatozoa, their mobility or morphology.
Pregnancy
In the post-registration period with use of acyclovir in any dosage form by women during pregnancy there was no increase in the number of congenital malformations in children compared with the general population; while the identified congenital malformations were not characterized by uniformity or patterns indicating a common cause of their occurrence. In systemic use of acyclovir, embryotoxic or teratogenic effects in rabbits, rats, or mice have not been identified in internationally accepted standardized tests.
In non-standard test on rats with subcutaneous administration of the drug in high doses, which exert a toxic effect on the female organism,observed malformations of the fetus. The clinical significance of these results is unknown.
The use of the drug during pregnancy is possible if the potential benefit to the mother exceeds the probability of the unknown risk for the fetus.
Breastfeeding period
Limited clinical data show, that the drug is found in breast milk at the system application, however, the quantity the drug that the baby will receive when breastfeeding, will be negligible.