To achieve maximum therapeutic effect, it is necessary to start using the drug as early as possible after the onset of infection (at the first signs of the disease: burning, itching, tingling, sensation of tension and redness). Ointment is not recommended to be applied to the mucous membranes of the mouth and eyes, as it is possible to develop a pronounced local inflammation.In the treatment of genital herpes, sexual intercourse or condom use should be avoided, since the use of acyclovir does not prevent the transmission of the virus to partners.