Acyclovir - instructions for use, dose, side effects, contraindications

Excipients: chicken oil (lipid component of bird fat [lipocomp-C]) - 200.0 mg, macrogol-400 - 300, 0 mg, emulsifier No. 1 - 80.0 mg, methyl parahydroxybenzoate - 0.8 mg, propyl parahydroxybenzoate 0.2 mg , purified water - up to 1.0 g.

Description:

Ointment is white or white with a yellowish hue.

Pharmacotherapeutic group:Antiviral for topical use

ATX: & nbsp

S.01.A.D Antiviral drugs

Pharmacodynamics:

Acyclovir is an antiviral agent from the group of synthetic analogs of acyclic purine nucleoside, deoxyguanidine, which is a component of DNA. Acyclovir has a high specificity for viruses Herpes simplex, 1 and 2 types, the virus causing varicella and shingles (Varicella zoster), the Epstein-Barr virus. Moderately active against cytomegalovirus.

Acyclovir penetrates directly into virus-infected cells. Cells infected with the virus produce viral thymidine kinase, which in turn phosphoresces acyclovir to acyclovir triphosphate, which is an active and selective inhibitor of DNA polymerase of viruses. Probably, the mechanism of inhibition by acyclovirtriphosphate of DNA synthesis consists in that it is a substrate for this enzyme, which makes it possible to carry out the 3'-5 'bond necessary for the extension of the DNA chain.

Thus, premature rupture of the DNA strand occurs, which leads to suppression of viral replication.

Pharmacokinetics:

When applying the ointment on intact skin: the absorption is minimal. Affected skin: moderate absorption.

Indications:

Skin infections caused by the virus Herpes simplex 1 and 2 types, genital herpes, shingles, chicken pox.

Contraindications:

Hypersensitivity to acyclovir or to any other component of the drug.

Dosing and Administration:

Outwardly. Ointment is applied to the affected areas 5 times a day, about every 3 hours. Ointment is applied either with a cotton swab or with clean hands to avoid additional infection of affected areas. Therapy should be continued until the time when no bubbles form on the vesicles, or until they completely heal. Duration of treatment - at least 5 days, a maximum of 10 days. If the symptoms persist for more than 10 days, or if the symptoms worsen significantly, you should consult your doctor.

Side effects:

Hyperemia, dryness, scaling of the skin; burning, inflammation in contact with mucous membranes. Possible the development of allergic dermatitis.

Interaction:

An increase in the effect is noted with the simultaneous appointment of an immunostimulant.

Special instructions:

Ointment should not be applied to the mucous membranes of the mouth, eyes, nose and vagina.The effectiveness of treatment will be higher the earlier it was started (at the first signs of infection). To realize the therapeutic effect of acyclovir, the state of the body's immune system is important. Patients with reduced immunity (with HIV / AIDS or after bone marrow transplantation) should receive systemic administration of the drug against the background of topical application of acyclovir ointment, as well as in case of severe and recurrent course of herpetic infection.

Acyclovir does not prevent sexual transmission of herpes, therefore during treatment it is necessary to abstain from sexual intercourse, even in the absence of clinical manifestations.

Efficacy and safety of use in children are not established.

Form release / dosage:Ointment for external use 5% for 5 and 10 g.

Packaging:

The tubes are made of aluminum. Each tube together with the instruction for use is placed in a pack of cardboard.

Storage conditions:

Store at a temperature not exceeding 25 ° C.

Keep out of the reach of children.

Shelf life:2 years. Do not use after the expiration date printed on the package.

Terms of leave from pharmacies:On prescription

Registration number:LS-001566

Date of registration:05.08.2011 / 10.12.2015

Expiration Date:Unlimited

The owner of the registration certificate:MUROMSKY INSTRUMENT-MAKING PLANT, OJSC MUROMSKY INSTRUMENT-MAKING PLANT, OJSC Russia

Manufacturer: & nbsp

MUROMSKY INSTRUMENT-MAKING PLANT, OJSC Russia

Information update date: & nbsp30.09.2017

Illustrated instructions

Instructions

Acyclovir (Aciclovir)