Acyclovir - instructions for use, dose, side effects, contraindications

Excipients: propylene glycol 40.0 g, petrolatum 12.5 g, paraffin liquid (vaseline oil) - 7.5 g, emulsion wax - 5.0 g, macrogol 1500 (polyethylene oxide 1500) - 1.0 g, purified water - up to 100.0 g.

Description:Ointment is white or white with a yellowish tint of color with a characteristic odor.

Pharmacotherapeutic group:Antiviral agent

ATX: & nbsp

S.01.A.D Antiviral drugs

Pharmacodynamics:

The antiviral drug is a synthetic analogue of thymidine nucleoside. In infected cells containing viral thymidine kinase, phosphorylation and conversion to acyclovir monophosphate occurs. Under the influence of guanylyl cyclase acyclovir, monophosphate is converted to diphosphate and under the influence of several cellular enzymes - into triphosphate. High selectivity of action and low toxicity for humans are due to the lack of the necessary enzyme for the formation of acyclovir triphosphate in intact cells of the macroorganism. Acyclovir triphosphate, "embedded" in the DNA synthesized by the virus, we block the multiplication of the virus. Specificity and very high selectivity of action are also due to its predominant accumulation in cells affected by the herpes virus. Highly active against herpes simplex virus (Herpes simplex) 1 and 2 types.

Pharmacokinetics:

With external application is practically not absorbed through intact skin, not is determined in the blood and urine. When applied to the affected skin, the absorption is moderate.

In patients with normal renal function, the serum concentration is up to 0.28 μg / ml,in patients with chronic renal failure (CRF) - up to 0.78 μg / ml. It is excreted by the kidneys (up to 9.4% of the daily dose).

Indications:Skin infections caused by the virus Herpes simplex types 1 and 2, incl. herpes lips.

Contraindications:

Hypersensitivity to acyclovir and other components of the drug.

Carefully:

Pregnancy, the period of breastfeeding.

Pregnancy and lactation:

Adequate and strictly controlled clinical studies of the safety of the drug during pregnancy and breastfeeding were not conducted. The application is shown only when the intended benefit to the mother exceeds the potential risk to the fetus and the baby. Before use, consult a physician.

Dosing and Administration:

Outwardly. To adults. The ointment is applied with a thin layer (approximately 1.25 cm of the ointment strip by 25 cm² affected skin) to affected areas 5 times a day (approximately every 4 hours). It is important to begin treatment as early as possible at the onset of the disease, with the first signs of infection. The duration of treatment is at least 5 days, a maximum of 10 days. If the symptoms do not disappear after 10 days of treatment, you should consult your doctor.

Side effects:

The incidence of side effects is classified according to the recommendations of the World Health Organization: very often -> 1/10; often from> 1/100 to <1/10: infrequently - from> 1/1000 to <1/100; rarely from> 1/1000 to <1/1000; very rarely (including individual messages) - <1/10000, the frequency is unknown - can not be calculated from the available data.

From the immune system: very rarely - anaphylactic reactions, including angioedema and urticaria.

From the skin and subcutaneous tissues: infrequent - a brief sensation of burning and tingling at the site of application, dry skin, scaling of the skin, itching, rarely erythema, contact dermatitis at the site of application.

If any of the side effects listed in the manual are aggravated or any other side effects not indicated in the instructions are noted, the doctor should be informed immediately.

Overdose:

Symptoms: when using the drug in accordance with the instructions for use, an overdose is unlikely. At casual intake the following symptoms are possible: neurologic disorders (headache, confusion), shortness of breath, nausea, vomiting, diarrhea, impaired function of the nights.

Treatment: maintenance of vital body functions, hemodialysis.

Interaction:

Clinically significant interactions with external application have not been identified.

Special instructions:

Ointment is not recommended to be applied to the mucous membranes of the mouth and nose, eyes and vagina, as it is possible to develop a pronounced local inflammation.

The effectiveness of treatment will be higher the earlier it is started (at the first signs of infection: sensation of tension, itching, burning, tingling, redness).

Patients with immunodeficiency states in the treatment of any infectious diseases should follow the recommendations of the doctor.

When pronounced manifestations of herpes lips is recommended to consult a doctor.

Effect on the ability to drive transp. cf. and fur:

Not studied.

Form release / dosage:Ointment for external use 5%.

Packaging:

Ointment for external use 5% to 3.0 g; 5,0 g or 10,0 g in tubes of aluminum with buds with an internal varnish covering. Each tube, together with the instruction for medical use, is placed in a pack of cardboard.

Storage conditions:

At a temperature of no higher than 25 ° C.

Keep out of the reach of children.

Shelf life:

3 years.Do not use the drug after the expiration date.

Terms of leave from pharmacies:Without recipe

Registration number:LP-004338

Date of registration:13.06.2017

Expiration Date:13.06.2022

The owner of the registration certificate:GREEN DUBRAVA, CJSC GREEN DUBRAVA, CJSC Russia

Manufacturer: & nbsp

GREEN DUBRAVA, CJSC Russia

Information update date: & nbsp23.10.2017

Illustrated instructions

Instructions

Acyclovir (Aciclovir)