Inside, during or immediately after eating, squeezed with enough water.The dose and duration of treatment are set individually, depending on the severity of the disease.
In the treatment of infections of the skin and mucous membranes caused by Herpes simplex type 1 and type 2, adults and children over 3 years of age, the drug is prescribed 200 mg 5 times a day for 5 days at 4 hour intervals during the day and with an 8 hour interval overnight. In more severe cases, the course of treatment can be extended to the doctor's prescription. As part of complex therapy in cases of severe immunodeficiency, including with the expanded clinical picture of HIV infection (including early clinical manifestations of HIV infection and stage of AIDS), 400 mg 5 times a day are prescribed after bone marrow transplantation.
Genital herpes: initial therapy - 200 mg every 4 hours during wakefulness, 5 times a day for 10 days. Recurrent genital herpes (less than 6 episodes a year): intermittent therapy - 200 mg every 4 hours during wakefulness, 5 times a day for 5 days. Recurrent genital herpes (more than 6 episodes a year): prolonged suppressive therapy - 400 mg 2 times a day or 200 mg 3-5 times a day.
To prevent recurrence of infections caused by viruses Herpes simplex 1 and 2 types, patients with normal immune status and recurrent disease are prescribed 200 mg 4 times a day every 6 hours. Treatment with the drug should be interrupted periodically for 6-12 months to identify possible changes in the course of the disease.
To prevent infections caused by viruses Herpes simplex 1 and 2 types, adults and children older than 3 years with immunodeficiency, the drug is recommended to appoint 200 mg 4 times a day every 6 hours, the maximum dose - up to 400 mg 5 times a day, depending on the severity of the infection. The duration of the preventive course of therapy is determined by the length of the period when there is a risk of infection.
In the treatment of infections caused by Varicella zoster, adults are prescribed 800 mg 5 times a day every 4 hours in the afternoon and with an 8-hour interval at night. Duration of treatment 7-10 days. Children older than 3 years with a body weight of less than 40 kg are prescribed 20 mg / kg 4 times a day for 5 days, children with a body weight of more than 40 kg of the drug are prescribed 800 mg 5 times a day every 4 hours in the afternoon and 8 hour interval at night, for 7-10 days.
In the treatment of infections caused by Herpes zoster, adults are prescribed 800 mg 4 times a day every 6 hours for 5 days.
In patients with impaired renal function:
In the treatment and prevention of infections caused by Herpes simplex, in patients with creatinine clearance less than 10 ml / min dose should be reduced to 200 mg 2 times a day from 12-hour intervals.
In the treatment of infections caused by Varicella zoster, in patients with creatinine clearance less than 10 ml / min, it is recommended to reduce the dose of the drug to 800 mg twice a day with 12-hour intervals; with a creatinine clearance of up to 25 ml / min, 800 mg 3 times a day with 8 hour intervals is prescribed.