Acyclovir Belupo - instructions for use, dose, side effects, contraindications

Excipients: propylene glycol, glyceryl monostearate and macrogol -100 stearate mixture, cetostearyl alcohol (cetyl alcohol 60%, stearic alcohol 40%), mineral oil, petrolatum, sodium lauryl sulfate, water, hydrochloric acid.

Description:White homogeneous cream without mechanical inclusions.

Pharmacotherapeutic group:Antiviral for topical use

ATX: & nbsp

S.01.A.D Antiviral drugs

Pharmacodynamics:

Acyclovir is an antiviral drug from the group of synthetic analogues of acyclic purine nucleoside-deoxyguanidine, which is a component of DNA.

Acyclovir is highly specific for the virus Herpes simplex 1 and 2 types; a virus that causes varicella and herpes zoster (Varicella zoster); the Epstein-Barr virus. Moderately active against the causative agent of cytomegalovirus infection.

Acyclovir penetrates directly into virus-infected cells. Cells infected with the virus produce viral thymidine kinase, which phosphorescrates acyclovir to acyclovir triphosphate. The latter interacts with the viral DNA polymerase, which is synthesized for new viruses. Thus, "defective" viral DNA is formed, which leads to suppression of replication of new generations of viruses.

Pharmacokinetics:

When applying the cream on intact skin: suction is minimal; not detected in blood and urine. Affected skin: moderate absorption.

Indications:Skin infections caused by the virus Herpes simplex types 1 and 2, genital herpes, shingles, chicken pox

Contraindications:Hypersensitivity to acyclovir or an auxiliary substance of the drug.

Carefully:Pregnancy, lactation, dehydration, renal failure.

Pregnancy and lactation:

Adequate and controlled clinical studies of drug safety during pregnancy have not been conducted.

Use during pregnancy is only possible if the intended benefit to the mother exceeds the potential risk to the fetus.

During the treatment period, it is necessary to resolve the issue of stopping breastfeeding.

Dosing and Administration:

Outwardly.

The drug is applied to damaged areas of the skin 5 times a day (every 4 hours) in a thin layer on the affected and adjacent areas of the skin. The cream is applied with a cotton swab, or with clean hands to avoid additional infection of the affected areas. Therapy should be continued until the time when no bubbles form on the vesicles, or until they completely heal.

Duration of treatment - at least 5 days, a maximum of 10 days.

Side effects:

Hyperemia, dryness, scaling of the skin; burning, inflammation in contact with mucous membranes. Possible the development of allergic dermatitis.

Interaction:

It is possible to enhance the effect with the simultaneous appointment of an immunostimulant.

Special instructions:

To achieve maximum therapeutic effect, it is necessary to start using the drug as early as possible after the onset of infection (at the first signs of the disease: burning, itching, tingling, sensation of tension and redness). The cream is not recommended to be applied to the mucous membranes of the mouth and eyes, as it is possible to develop pronounced local inflammation.

Acyclovir does not prevent sexual transmission of herpes, therefore during treatment it is necessary to abstain from sexual intercourse, even in the absence of clinical manifestations.

Form release / dosage:

Cream for external use 5%.

Packaging:

By 2, 5 and 10 grams in aluminum tubes.

The tube opening is protected by a membrane.

The tube is closed with a polyethylene lid with a thread and a pin for piercing the membrane.

Each tube together with the instruction for use is placed in a cardboard box.

Storage conditions:At a temperature of no higher than 25 ° C. Keep out of the reach of children!

Shelf life:

2 years.

Do not use after the expiry date printed on the package.

Terms of leave from pharmacies:Without recipe

Registration number:LSR-003654/07

Date of registration:07.11.2007

Expiration Date:Unlimited

The owner of the registration certificate:Beluga, medicines and cosmetics.Beluga, medicines and cosmetics. Croatia

Manufacturer: & nbsp

BELUPO, Pharmaceuticals & Cosmetics, d.d. Croatia

Representation: & nbspBeluga, medicines and cosmetics. Beluga, medicines and cosmetics. Croatia

Information update date: & nbsp22.09.2017

Illustrated instructions

Instructions

Acyclovir Belupo (Aciclovir Belupo)