Acyclovir - instructions for use, dose, side effects, contraindications

Excipients: propylene glycol 40.00 g, poloxamer 407 1.00 g, glyceryl monostearate 40-55 type II 0.75 g, macrogol 20 stearate type 1-0.75 g, emulsifier No. 1 7.50 g, dimethicone 100 - 1.00 g, vaseline - 11.50 g, liquid paraffin (vaseline oil) - 5.00 g, water - up to 100.0 g.

Description:Homogeneous cream white or almost white.

Pharmacotherapeutic group:Antiviral agent

ATX: & nbsp

S.01.A.D Antiviral drugs

Pharmacodynamics:

Acyclovir is active in vitro in a relationship Herpes simplex 1 and 2 types, virus Varicella zoster, the Epstein-Barr virus and cytomegaloviruses. Thymidine kinase virus-infected cells through a series of consecutive reactions actively converts the acylClovor in mono-, di- and triphosphate Acyclovir. The latter interacts with the viral DNA polymerase and is embedded in DNA, which is synthesized for new viruses. Thus, "defective" viral DNA is formed, which leads to suppression of replication of new generations of viruses.

Pharmacokinetics:

With external application is practically not absorbed through intact skin, not detected in blood and urine. When applied to the affected skin suction moderate.

In patients with normal renal function, the serum concentration in the serum is up to 0.28 μg / ml, in patients with chronic renal insufficiency it is up to 0.78 μg / ml. It is excreted by the kidneys (up to 9.4% of the daily dose).

Indications:Skin infections caused by the virus Herpes simplex types 1 and 2, including herpes lips.

Contraindications:

Hypersensitivity to acyclovir and other components of the drug.

Carefully:

Pregnancy, the period of breastfeeding.

Pregnancy and lactation:

In pregnancy and during breastfeeding apply only if the intended benefit to the mother exceeds the potential risk to the fetus and the baby.

Dosing and Administration:

Outwardly.

To adults. The drug is applied 5 times a day (every 4 hours) in a thin layer on the affected and adjacent areas of the skin. The cream is applied either with a cotton swab or with clean hands to avoid additional infection of the affected areas. It is important to begin treatment as soon as possible at the beginning of the disease, best of all - during the prodromal period.

Therapy should be continued until the time when no bubbles form on the vesicles, or until they completely heal.

The duration of therapy is an average of 5 days and should not exceed 10 days.

Side effects:

Undesirable reactions are presented in accordance with the classification of the World Health Organization (WHO) according to the frequency of development, depending on the degree frequency of occurrence: very often (≥ 1/10), often (from ≥ 1/100 to <1/10), infrequently (from ≥ 1/1000 to <1/100), rarely (from ≥ 1/10 000 to <1/1 000), very rarely (<1/10 000), the frequency is unknown (to determine the frequency of which, the data is not enough).

From the skin:

Infrequent: burning sensation after application of the cream, with time, dry skin, itching, tingling at the site of application, peeling of the skin;

Rarely: erythema, contact dermatitis at the site of application.

From the immune system:

Very rarely: anaphylactic reactions, including angioedema and urticaria.

If any of the side effects listed in the manual are aggravated, or if you notice any other side effects not listed in the instructions, tell your doctor.

Overdose:

Symptoms: (with accidental ingestion): headache, neurologic disorders, shortness of breath, nausea, vomiting, diarrhea, impaired renal function.

Treatment: maintenance of vital functions, hemodialysis.

Interaction:

With external application, no interaction with other drugs has been identified.

Special instructions:

To achieve maximum therapeutic effect, it is necessary to start using the drug as early as possible after the onset of infection (at the first signs of the disease: burning, itching, tingling, sensation of tension and redness).

The cream is not recommended to be applied to the mucous membranes of the mouth, eyes, nose and vagina, as it is possible to develop pronounced local inflammation. Patients with immunodeficiency states in the treatment of any infectious diseases should follow the recommendations of the doctor.

Effect on the ability to drive transp. cf. and fur:

Not studied.

Form release / dosage:

Cream for external use 5%.

Packaging:

By 2 g, 5 g or 10 g in aluminum tubes.

By 5, 10, 15, 20, 25, 30, 35 or 50 g in cans of dark glass such as BTS from glass melt with tight lids. The label is self-adhesive on the can.

Each tube or jar, together with the instruction for use, is placed in a cardboard package (bundle).

Storage conditions:

In the dark place at a temperature of no higher than 25 ° C.

Keep out of the reach of children.

Shelf life:3 years. Do not use after the expiration date.

Terms of leave from pharmacies:Without recipe

Registration number:LP-002794

Date of registration:29.12.2014

Expiration Date:29.12.2019

The owner of the registration certificate:ATOLL, LLC ATOLL, LLC Russia

Manufacturer: & nbsp

OZONE, LLC Russia

Information update date: & nbsp30.09.2017

Illustrated instructions

Instructions

Acyclovir (Aciclovir)