Adults
For patients with obesity, the dose should be calculated from the ideal body weight, rather than from the actual body weight of the patient.
Treatment of infections caused by herpes simplex viruses (HSV, with the exception of herpetic encephalitis) and the virus of chickenpox and herpes zoster (VZV).
Intravenous infusions in a dose of 5 mg / kg every 8 hours.
Treatment of infections caused by VZV, and herpetic encephalitis in patients with immunodeficiency.
Intravenous infusions at a dose of 10 mg / kg every 8 hours with normal kidney function.
Prevention of CMV infection in bone marrow transplantation.
500 mg / m2 intravenously 3 times a day with an interval of 8 hours. The duration of treatment is from 5 days to transplantation and up to 30 days after transplantation.
Children
In newborn doses are calculated depending on the body weight. With infections, caused by HSV, a dose of 10 mg / kg is recommended every 8 hours.
Doses of acyclovir for intravenous infusions in children aged 3 months to 12 years are calculated depending on the body surface area.
Treatment of infection caused by HSV (other than herpetic encephalitis) and VZV.
Intravenous infusions in a dose of 250 mg / m2 every 8 hours.
Treatment of herpetic encephalitis and infections caused by WBC in children with immunodeficiency.
Intravenous infusions in a dose of 500 mg / m2 every 8 hours with normal kidney function.
Prevention of CMV infection in children older than 2 years.
Few data suggest that children older than 2 years who have undergone bone marrow transplantation can be assigned an adult dose of acyclovir, a lyophilizate for the preparation of a solution for infusions.
Children with reduced renal function require a dose adjustment in accordance with the degree of renal failure.
Elderly patients
It is necessary to take into account the possibility of renal failure in elderly patients, the doses should be adjusted in accordance with the degree of renal failure.It is necessary to ensure the maintenance of an adequate water balance.
Patients with renal insufficiency
Intravenous infusions of acyclovir should be administered with caution in patients with renal insufficiency. The following scheme of correction of doses is proposed depending on the degree of decrease in creatinine clearance:
| Creatinine clearance | Doses |
| 25-50 ml / min | 5-10 mg / kg every 12 hours |
| 10-25 ml / min | 5-10 mg / kg every 24 hours |
| 0 (anuria-) - 10 ml / min | With continuous ambulatory peritoneal dialysis, 5-10 mg / kg every 24 hours. With hemodialysis, 5-10 mg / kg every 24 hours and after dialysis. |
The course of treatment with acyclovir in the form of intravenous infusions is usually 5 days, but may vary depending on the patient's condition and response to therapy.
The duration of the preventive use of acyclovir for intravenous infusions is determined by the duration of the period when there is a risk of infection.
Preparation of solution and method of administration.
Recommended The dose of acyclovir should be administered as a slow intravenous infusion for 1 hour.
10 ml of the dilution solution (water for injection or sodium chloride solution for injection (0.9%)) is used to prepare the solution acyclovir with a content of 1 ml of the resulting solution of 25 mg of acyclovir.
The recommended volume of dilution solution must be added to the powder bottle of the preparation Acyclovir, shake gently until the contents of the vial completely dissolve.
After dilution, the solution of acyclovir can be administered as an intravenous infusion with the help of a special infusion pump that regulates the rate of administration of the drug.
Another method of infusion administration is possible when the prepared solution of acyclovir is diluted further to obtain an acyclovir concentration not exceeding 5 mg / ml (0.5%).
To do this, add the prepared solution to the selected infusion solution, which is recommended below, and shake well until the solutions are completely mixed.
For children and newborns who need to enter minimal infusion volumes, it is recommended to add 4 ml of the prepared aciclovir solution (100 mg of acyclovir) to 20 ml of the solvent.
For adults, it is recommended to use infusion solutions in packs of 100 ml, even if this gives the concentration of acyclovir significantly below 0.5 %. Thus, one 100 ml infusion solution can be used for any dose of acyclovir between 250 mg and 500 mg (10 and 20 ml diluted solution). For doses between 500 and 1000 mg of acyclovir, another solution for infusion of this volume (100 ml) should be used.
Acyclovir, a lyophilizate for the preparation of a solution for infusions, is compatible with the following infusion solutions and remains diluted with them for 12 hours at room temperature (from 15 0 C to 25 ° C):
- Sodium chloride for intravenous infusions (0.45% and 0.9%)
- Hatria chloride (0.18%) and glucose (4%) for intravenous infusions
- Sodium chloride (0.45%) and glucose (2.5%) for intravenous infusions
- Hartman's solution.
Since no antibacterial preservative is included in the solution, Dissolution and dilution should be carried out completely in aseptic conditions immediately prior to administration of the preparation. The unused solution is destroyed. If the solution is cloudy or the crystals fall out, it must be destroyed.