Acyclovir - instructions for use, dose, side effects, contraindications

Acyclovir is active against Herpes simplex 1 and 2 types, virus Varicella zoster, the Epstein Barr virus and cytomegaloviruses. Thymidine kinase virus-infected cells through a series of consecutive reactions actively converts acyclovir in mono-, di- and triphosphate of acyclovir. The latter interacts with the viral DNA polymerase and is embedded in DNA, which is synthesized for new viruses. Thus, "defective" viral DNA is formed, which leads to suppression of replication of new generations of viruses.

Pharmacokinetics:

At local use it is practically not absorbed through the damaged skin, does not enter the systemic bloodstream.

Indications:Infections of the skin and mucous membranes caused by the virus Herpes simplex types 1 and 2, genital herpes, shingles, chicken pox.

Contraindications:

Hypersensitivity to acyclovir and other components of the drug.

Carefully:Pregnancy, lactation, dehydration, renal failure.

Pregnancy and lactation:

Adequate and controlled clinical studies of safety of the drug during pregnancy were not conducted. The application is shown only in those cases,when the intended use for the mother exceeds the potential risk to the fetus.

During the treatment period, it is necessary to resolve the issue of stopping breastfeeding.

Dosing and Administration:

Outwardly. The drug is applied 5 times a day (every 4 hours) in a thin layer on the affected and adjacent areas of the skin. Ointment is applied either with a cotton swab or with clean hands to avoid additional infection of affected areas. Therapy should be continued until the time when no bubbles form on the vesicles, or until they completely heal. The duration of therapy is an average of 5 days and should not exceed 10 days.

Side effects:

Hyperemia, dryness, scaling of the skin; burning, inflammation in contact with mucous membranes. Possible the development of allergic dermatitis.

Interaction:

With external application, no interaction with other drugs has been identified.

Special instructions:

To achieve maximum therapeutic effect, it is necessary to start using the drug as early as possible after the onset of infection (at the first signs of the disease: burning, itching, tingling, sensation of tension and redness).

Ointment is not recommended to be applied to the mucous membranes of the mouth and eyes, as it is possible to develop a pronounced local inflammation. In the treatment of genital herpes, sexual intercourse or condom use should be avoided, since the use of acyclovir does not prevent the transmission of the virus to partners.

Form release / dosage:5% ointment for external use.

Packaging:

In tubes of aluminum for 10 g, 30 g. Together with the instruction for use are placed in a pack of cardboard.

Storage conditions:In a dry, cool, protected from light and out of reach of children.

Shelf life:

2 years. Do not use after the expiration date.

Terms of leave from pharmacies:Without recipe

Registration number:LSR-010797/08

Date of registration:29.12.2008

Expiration Date:Unlimited

The owner of the registration certificate:ALTAYVITAMINS, CJSC ALTAYVITAMINS, CJSC Russia

Manufacturer: & nbsp

ALTAYVITAMINS, CJSC Russia

Information update date: & nbsp30.09.2017

Illustrated instructions

Instructions

Acyclovir (Aciclovir)