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India Virollex cream externally KRKA, dd, Novo mesto, AO Virollex lyophilizate d / infusion KRKA, dd, Novo mesto, AO Gervirax cream externally PHARMACEUTICAL FACTORY of St. Petersburg, JSC Russia Gerperax ointment externally Micro Labs Limited India Gerperax pills inwards Micro Labs Limited India Zovirax ® lyophilizate d / infusion GlaxoSmithKline Trading, ZAO Russia Zovirax ® ointment d / eye GlaxoSmithKline Trading, ZAO Russia Zovirax ® pills inwards GlaxoSmithKline Trading, ZAO Russia Zovirax ® cream externally GlaxoSmithClean Consumer Helscher United Kingdom Medovir powder d / infusion Medocemi Co., Ltd. Cyprus Provirsan® pills inwards PRO.MED.CS Prague as. Czech Republic Dosage form: & nbspointment for topical and topical application Composition:Acyclovir - 50 mg per 1 g of ointment. Excipients - a two-component mixture of macroheads 400 and 1500. Description:Homogeneous white ointment with a weak characteristic odor. Pharmacotherapeutic group:Antiviral for topical use ATX: & nbspS.01.A.D Antiviral drugs Pharmacodynamics:Acyclovir is active against Herpes simplex 1 and 2 types, virus Varicella zoster, the Epstein-Barr virus and cytomegaloviruses. Thymidine kinase infected cells through a series of consecutive reactions actively converts acyclovir in mono-, di- and triphosphate of acyclovir. The latter interacts with the viral DNA polymerase and is embedded in DNA, which is synthesized for new viruses. Thus, "defective" viral DNA is formed, which leads to suppression of replication of new generations of viruses. Pharmacokinetics:Acyclovir is absorbed through the epithelium when applied locally. The degree of absorption is an average of 9.38 ± 1.64% of the applied dose. Binding to blood plasma proteins averages 15.4 ± 4.4%. The main metabolite of acyclovir is 9-carboxymethoxymethylguanine. Acyclovir more than 95% is excreted through the kidneys unchanged for 24 hours after application of the drug. Indications:Infections of the skin and mucous membranes caused by the virus Herpes simplex types 1 and 2 - herpes of the lips, genital herpes, shingles. Contraindications:Hypersensitivity to acyclovir and other components of the drug. Children under 18 years (due to lack of experience with the drug). Carefully:Pregnancy and lactation. Pregnancy and lactation:In pregnancy, use is indicated only in cases where the intended benefit to the mother exceeds the potential risk to the fetus. Dosing and Administration:Locally and externally. The drug is recommended to apply 5 times a day (every 4 hours) a thin layer on the affected and adjacent areas of skin and mucous membranes. Ointment is applied either with a cotton swab or with clean hands to avoid additional infection of affected areas. Therapy should be continued until the time when no bubbles form on the vesicles, or until they completely heal. The duration of therapy is an average of 5 days and should not exceed 10 days. Side effects:Possible short-term allergic reactions in the areas of application, redness, itching, flaking, burning or tingling, skin rash, vulvitis. In very rare cases, the development of allergic dermatitis. Overdose:Symptoms: headache, neurological disorders, shortness of breath, nausea, vomiting, diarrhea, impaired renal function, lethargy, convulsions, coma. In case of an overdose acyclovir is output by hemodialysis. Interaction:With external application, no interaction with other drugs has been identified. Special instructions:To achieve maximum therapeutic effect, it is necessary to apply the drug already at the first signs of the disease (burning, itching, tingling, sensation of tension and redness). Ointment is not recommended to be applied to the mucous membranes of the mouth and eyes, as it is possible to develop a pronounced local inflammation. In the treatment of genital herpes, sexual intercourse or condom use should be avoided, since the use of acyclovir does not prevent the transmission of the virus to partners. Form release / dosage:Ointment for topical and topical application 5%. Packaging:In tubes of 2 g, 3 g, 5 g and 10 g. The tube together with the instruction for use is placed in a cardboard box. Storage conditions:List B. In dry, dark place at a temperature of no higher than 25 ° C. Open the tube should be used within 1 month. Shelf life:4 years. Do not use after the expiration date. Terms of leave from pharmacies:Without recipe Registration number:P N000115 / 04 Date of registration:05.03.2009 Expiration Date:Unlimited The owner of the registration certificate:AZT PHARMA KB, LLC AZT PHARMA KB, LLC Russia Manufacturer: & nbspAZT PHARMA KB, LLC Russia Information update date: & nbsp30.09.2017 Illustrated instructions × Illustrated instructions Instructions