Intravenously drip for at least 1 hour.
The contents of the vial are dissolved in aseptic conditions immediately before use.To prepare the solution use water for injection or 0.9% solution of sodium chloride: 10 ml of solution is added to the bottle and intensively
stir until completely dissolved. The resulting solution is further diluted to a final concentration of acyclovir - no more than 0.5% (5 mg / ml): usually the contents of one vial (250 mg of acyclovir) are diluted in at least 50 ml of saline or, respectively, the contents of two bottles (500 mg acyclovir) in 100 ml of physiological saline. Thus, the resulting solution is used for intravenous slow or drop infusion.
To administer the solution to children and newborns, where the volume of infusion fluid should be minimized, it is recommended to dissolve the contents of one vial (250 mg of acyclovir) in 10 ml of water for injection or saline. Then add the infusion solution in an amount corresponding to the proportion: 1: 5. For example, in order to obtain a solution containing 100 mg of acyclovir, add 20 ml of the infusion solution to 4 ml of the resulting solution until a final solution with a concentration of 5 mg / ml of acyclovir is obtained.
As infusion solutions use: isotonic sodium chloride solution (0.9%) or Ringer's lactate solution.
The prepared solution remains stable for 12 hours at a temperature of 15 to 25 ° C.
Solutions should not be frozen. If it is found in the solutions prepared for infusion of any opacities or crystallization, they can not be used.
Adults:
Acyclovir is injected intravenously at a constant rate for 1 hour.
With severe genital herpes: initial therapy - adults and children over 12 years - 5 mg / kg every 8 hours for 5-7 days; children under 12 years of age - 250 mg / sq. m. every 8 hours for 5-7 days.
In the treatment of herpes simplex with lesions of the skin and mucous membranes in patients with a decreased immune status: adults and children over 12 years of age - 5-10 mg / kg every 8 hours for 7 days; children under 12 years of age - 250 mg / m each2 every 8 hours for 7 days.
Encephalitis caused by the virus Herpes simplex 1 and 2 types: adults and children over 12 years of age - 10 mg / kg every 8 hours, children from 3 months to 12 years - 20 mg / kg every 8 hours (or 500 mg / m2 every 8 hours). The average course of treatment is 20 days.
With herpes zoster caused by the virus Varicella zoster in patients with impaired immunity: adults and children over 12 years of age - 10 mg / kg every 8 hours for 7-10 days; children under 12 years of age - 20 mg / kg every 8 hours (or 500 mg / m2 every 8 hours) for 7-10 days.
Generalized infection in newborns, virus-induced Herpes simplex: newborns and children up to 3 months - 10 mg / kg every 8 hours. The average course of treatment is 10 days. It is possible to increase the dose to 15-20 mg / kg every 8 hours, however, the effectiveness and safety of the use of such doses are not established.
To patients of advanced age
A dose reduction may be required.
In case of impaired renal function
| Creatinine clearance | Dose |
| 25-50 ml / min | 5-10 mg / kg body weight or 500 mg / m2 every 12 hours |
| 10-25 ml / min | 5-10 mg / kg body weight or 500 mg / m2 every 24 hours |
| 0-10 ml / min | Patients on peritoneal dialysis 2.5-5 mg / kg body weight, or 250 mg / m2 every 24 hours Patients on hemodialysis 2.5-5 mg / kg body weight, or 250 mg / m2 every 24 hours and after dialysis. |