Acyclovir - instructions for use, dose, side effects, contraindications

Excipients: propylene glycol 8.0 g; paraffin liquid (vaseline oil) - 12.0 g; cetyl alcohol - 6.0 g; macrogol 6 cetostearyl ether - 1.5 g; macrogol 25 cetostearyl ether - 1.5 g; methyl parahydroxybenzoate (methylparaben, nipagin) 0.15 g; propyl parahydroxybenzoate (propylparaben, nipazole) 0.05 g; purified water - up to 100.0 g.

Description:Homogeneous cream white or almost white.

Pharmacotherapeutic group:Antiviral for topical use

ATX: & nbsp

S.01.A.D Antiviral drugs

Pharmacodynamics:

The antiviral drug is a synthetic analogue of thymidine nucleoside. In infected cells containing viral thymidine kinase, phosphorylation and conversion to acyclovir monophosphate occurs. Influenced

guanylyl cyclase acyclovir monophosphate is converted into acyclovir di-phosphate and under the influence of several cellular enzymes - into acyclovir triphosphate. High selectivity of action and low toxicity for humans are due to the lack of the necessary enzyme for the formation of acyclovir triphosphate in intact cells of the macroorganism.

Acyclovirte triphosphate, "embedded" in the virus-synthesized deoxyribonucleic acid (DNA), blocks the multiplication of the virus. Specificity and very high selectivity of action are also due to its predominant accumulation in cells affected by the herpes virus. Highly active against the virus Herpes simplex 1 and 2 types; a virus that causes varicella and shingles (Varicella zoster); of the Epstein-Barr virus (virus types are listed in order of increasing value of the minimum inhibitory concentration (MIC) of acyclovir). Moderately active against cytomegalovirus (CMV).

With herpes, prevents the formation of new elements of the rash, reduces the likelihood of cutaneous dissemination and visceral complications, accelerates the formation of crusts, reduces pain in the acute phase of herpes zoster.

Pharmacokinetics:When applying the cream on intact skin: suction is minimal; not detected in blood and urine. Affected skin: moderate absorption, in patients with normal renal function, the serum concentration is up to 0.28 μg / ml, in patients with chronic renal insufficiency it is up to 0.78 μg / ml. It is excreted by the kidneys (up to 9.4% of the daily dose).

Indications:

Herpes simplex skin and mucous membranes, genital herpes (primary and recurrent); localized shingles (ancillary therapy).

Contraindications:

Hypersensitivity to any component of the drug.

Pregnancy and lactation:Pregnant women and women in the period of breastfeeding the drug is recommended to use only,when the benefits of the application for the mother exceed the potential risk to the fetus / child.

Dosing and Administration:

Outwardly. Locally.

Cream Acyclovir Apply a thin layer (approximately 1.25 cm of cream strip for 25 cm²affected skin) to affected areas 4-6 times a day. It is important to begin treatment as soon as possible at the beginning of the disease, best of all - during the prodromal period.

The cream is applied either with a cotton swab or with clean hands to avoid additional infection of the affected areas.

Duration of treatment - at least 5 days, a maximum of 10 days.

If the symptoms do not disappear after 10 days of treatment, the patient should consult a doctor.

Side effects:

Hyperemia, burning sensation, tenderness, itching, skin rash, vulvitis at the site of application. Perhaps the development of allergic reactions.

Postmarketing experience: swelling at the site of application.

Overdose:

Symptoms (with accidental ingestion): headache, neurologic disorders, shortness of breath, nausea, vomiting, diarrhea, impaired renal function.

Treatment: maintenance of vital functions, hemodialysis.

Interaction:

An increase in the effect is noted with the simultaneous appointment of immunostimulants.

Special instructions:

Use with caution during pregnancy and during breastfeeding. The cream should not be applied to the mucous membranes of the mouth and eyes. The effectiveness of treatment will be higher the earlier therapy is started (at the first signs of infection).

Acyclovir does not prevent sexual transmission of herpes, therefore during treatment it is necessary to abstain from sexual intercourse, even in the absence of clinical manifestations.

To realize the therapeutic effect of acyclovir, the state of the body's immune system is important. Patients with reduced immunity (for HIV / AIDS or after bone marrow transplantation) should consult a doctor, as against topical application of acyclovir cream should be administered systemic administration of the drug, as well as in the case of a severe and recurrent course of herpetic infection.

Effect on the ability to drive transp. cf. and fur:No data.

Form release / dosage:

Cream for local and external use 5%.

Packaging:

By 2 g, 5 g or 10 g in aluminum tubes.

Each tube together with instructions for use in a pack of cardboard.

Storage conditions:At a temperature not higher than 25 ° C. Keep out of the reach of children.

Shelf life:

2 years.

Do not use after expiry date.

Terms of leave from pharmacies:Without recipe

Registration number:LP-000661

Date of registration:28.09.2011

The owner of the registration certificate:VERTEKS, AO VERTEKS, AO Russia

Manufacturer: & nbsp

VERTEKS, AO Russia

Information update date: & nbsp27.08.2013

Illustrated instructions

Instructions

Acyclovir (Aciclovir)