Inside. The drug is taken during or immediately after a meal and is washed down with a sufficient amount of water.
The dosage regimen is set individually, depending on the severity of the disease.
In the treatment of infections of the skin and mucous membranes caused by Herpes simplex type I and II: Adults: the drug is prescribed at 200 mg 5 times a day for 5 days with 4 hour intervals during the day and with an 8-hour interval at night. In more severe cases of the disease, the course of treatment can be extended to the doctor's prescription up to 10 days. As part of complex therapy with severe immunodeficiency, including when the clinical picture of HIV infection (including, early clinical manifestations of HIV infection and stage of AIDS), after the implantation of the bone marrow is prescribed 400 mg 5 times a day.
To prevent recurrence of infections caused by viruses Herpes simplex type I and II, patients with normal immune status and relapse of the disease are prescribed 200 mg 4 times a day every 6 hours, the duration of the course is from 6 to 12 months.
To prevent infections caused by viruses Herpes simplex type I and II, adults with immunodeficiency, the drug is recommended to appoint 200 mg 4 times a day every 6 hours, the maximum dose - up to 400 mg of acyclovir 5 times a day, depending on the severity of the infection.
Children: for infection caused by Herpes simplex, and prevention of this infection in patients with weakened immune defenses, children older than 3 years receive the same dose as adults.
In the treatment of infections caused by Varicella zoster:
Adults: the drug is given 800 mg 5 times a day every 4 hours in the afternoon and with an 8-hour interval at night. Duration of treatment 7-10 days.
Children: with chickenpox appoint 20 mg / kg 4 times a day for 5 days (maximum single dose 800 mg), children from 3 years to 6 years: 400 mg 4 times a day, over 6 years: 800 mg 4 times daily for 5 days.
In the treatment of infections caused by Herpes zoster, adults are prescribed 800 mg 4 times a day every 6 hours for 5 days.
In patients with impaired renal function:
In the treatment and prevention of infections caused by Herpes simplex, in patients with creatinine clearance less than 10 ml / min, the dosage of the drug should be reduced to 200 mg twice a day with 12-hour intervals.
In the treatment of infections caused by Varicella zoster, in patients with a creatinine clearance less than 10 ml / min, it is recommended to reduce the dosagedrug up to 800 mg 2 times a day with 12-hour intervals; with a creatinine clearance of up to 25 ml / min, 800 mg 3 times a day with 8 hour intervals is prescribed.