Active substanceDextroseDextrose
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  • Dosage form: & nbspsolution for infusions
    Composition:

    1 liter of solution contains:

    Active substances:


    glucose monohydrate (dextrose)

    220.00 g

    (which corresponds to glucose anhydrous)

    200.00 g

    Excipients:


    water for injection

    up to 1 liter

    25% hydrochloric acid (for pH correction)

    q.s

    sodium hydroxide (for pH correction)

    q.s

    Energy value

    3360 kJ / l (= 800 kcal / l)

    Theoretical osmolality

    1110 mOsm / l

    Description:

    A clear, colorless solution.

    Pharmacotherapeutic group:Nutrition carbohydrate remedy
    ATX: & nbsp

    B.05.C   Irrigation solutions

    V.06.D   Other medications for nutrition

    V.04.C   Other diagnostic preparations

    Pharmacodynamics:

    Through participation in various metabolic processes dextrose has a diverse effect on the body: enhances oxidation-reduction processes in the body, improves the antitoxic function of the liver.

    The infusion of dextrose solutions partially replenishes the water deficiency. Dextrose, entering the tissue, phosphorylated, turning into glucose-6-phosphate, which is actively included in many parts of the body's metabolism.

    With the metabolism of dextrose in tissues, a significant amount of energy necessary for the vital activity of the body is released.

    Hypertensive solutions (20%) increase osmotic blood pressure, improve metabolism, increase myocardial contractility, improve the antitoxic function of the liver, dilate blood vessels, increase diuresis.
    Pharmacokinetics:It is absorbed completely by the body, the kidneys are not excreted (the appearance in the urine is a pathological sign).
    Indications:

    Hypoglycemia, insufficiency of carbohydrate nutrition, toxicinfection, intoxication with liver diseases (hepatitis, dystrophy and atrophy of the liver, including hepatic insufficiency), hemorrhagic diathesis; dehydration (vomiting, diarrhea, postoperative period); intoxication; collapse, shock.

    It is a component of various blood-substituting and anti-shock fluids; for preparation of solutions of drugs for intravenous administration.

    Contraindications:

    Hypersensitivity, hyperglycemia, diabetes mellitus, hyperlactacidemia, hyperhydration, postoperative disorders of glucose utilization; circulatory disorders that threaten edema of the brain and lungs; edema of the brain, pulmonary edema, acute left ventricular failure, hyperosmolar coma.

    Carefully:

    Decompensated heart failure, chronic renal failure (oligo-, anuria), hyponatremia.

    Pregnancy and lactation:

    Possible use during pregnancy and during breastfeeding.

    Dosing and Administration:

    Intravenously drip.

    20% solution - up to 30-40 drops / min (1,5-2 ml / min); the maximum daily intake for adults is 500 ml.

    In adults with a normal metabolism, the daily dose of dextrose administered should not exceed 4-6 g / kg, i.e. about 250-450 g (with a decrease in the metabolic rate, the daily dose is reduced to 200-300 g), while the daily volume of the injected liquid is 30-40 ml / kg.

    Children for parenteral nutrition, along with fats and amino acids, 6 g of dextrose / kg / day are administered on the first day, followed by up to 15 g / kg / day.

    The rate of administration: in the normal state of metabolism, the maximum rate of dextrose administration to adults is 0.25-0.5 g / kg / h (with a decrease in the intensity of the metabolism, the rate of administration is reduced to 0.125-0.25 g / kg / h). In children, the rate of dextrose administration should not exceed 0.5 g / kg / h.

    For more complete assimilation of dextrose, administered in large doses, simultaneously with her, insulin is prescribed at the rate of 1 unit of insulin per 4-5 g of dextrose.

    Diabetic patients with dextrose are administered under the control of its content in the blood and urine.
    Side effects:

    Hyperglycemia, hypervolemia, acute left ventricular failure.

    At the injection site - the development of infection, thrombophlebitis.

    Overdose:

    Symptoms: hyperglycemia, glucosuria, hyperglycemic hyperosmolar coma, hyperhydration, disturbance of water-electrolyte balance, intensification of liponeogenesis with increased production CO2, which leads to a sharp increase in the minute respiratory volume and, as a consequence, respiratory rate; fatty liver infiltration.

    Treatment: to stop the introduction of glucose, to introduce insulin, symptomatic therapy.

    Interaction:

    When combined with other drugs, it is necessary to control the pharmaceutical compatibility, incl. visually.

    Special instructions:
    Precautions for use

    It is necessary to control the water balance, the level of electrolytes and the acid-alkaline state of the patient.

    Regular monitoring of blood glucose levels is required.

    Only for single dosing.

    Mix the drug with additives necessary in accordance with the conditions of asepsis.

    Use only a clear, non-mechanically incorporated solution of undamaged packaging.

    For more complete and rapid assimilation of dextrose, it is possible to administer 4-5 units of insulin subcutaneously, at the rate of 1 unit of insulin per 4-5 g of dextrose.

    Effect on the ability to drive transp. cf. and fur:

    It was not reported on the effect of the drug on the ability to drive and work with machinery.

    Form release / dosage:Solution for infusions, 20%.
    Packaging:

    250 ml, 500 ml or 1000 ml in glass bottles for infusion solutions of glass of hydrolytic class II, sealed with rubber (halobutyl) stoppers, coated with aluminum caps, equipped with plastic caps-control the first opening (He.F.). For 6 or 10 vials, together with holders for bottles or without them, with instructions for use are placed in a cardboard box (for hospitals).

    To 250 ml, 500 ml or 1000 ml in a plastic bottle, equipped with a loop-holder for a dropper, sealed with a plastic combination of the proprietary cap "spike-shape". For 10 or 20 bottles together with the instruction for use are placed in a carton box (for hospitals).

    Storage conditions:

    In the dark place at a temperature of no higher than 25 FROM.

    Keep out of the reach of children.

    Shelf life:

    5 years.

    Do not use after the expiry date printed on the package.

    Terms of leave from pharmacies:For hospitals
    Registration number:П N011834 / 01
    Date of registration:30.09.2011
    Expiration Date:Unlimited
    The owner of the registration certificate:Fresenius Kabi Deutschland GmbHFresenius Kabi Deutschland GmbH Germany
    Manufacturer: & nbsp
    Representation: & nbspFRESENIUS KABI DEYCHLAND GmbH FRESENIUS KABI DEYCHLAND GmbH Germany
    Information update date: & nbsp22.04.2017
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