Active substanceDextroseDextrose
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  • Dosage form: & nbspsolution for infusions
    Composition:

    Dextrose (glucose) 50.0 or 100.0 g in terms of anhydrous, sodium chloride 0.26 g, a solution of hydrochloric acid 1 M to a pH of 3.0-5.0, water for injection up to 1000 ml.

    Description:Transparent, colorless or slightly yellowish liquid.
    Pharmacotherapeutic group:Nutrition carbohydrate remedy
    ATX: & nbsp

    B.05.C   Irrigation solutions

    V.06.D   Other medications for nutrition

    V.04.C   Other diagnostic preparations

    Pharmacodynamics:

    Glucose increases oxidation-reduction processes in the body, improves the antitoxic function of the liver, covers part of the energy expenditure of the body.

    The infusion of glucose solutions quickly replenishes the water deficiency. Glucose entering the tissues is phosphorylated, turning into glucose-6-phosphate, which is actively included in many parts of the body's metabolism.

    Isotonic 5% solution glucose has a detoxification and metabolic action, restores the volume of circulating blood, is a source of easily digestible nutrient. With the metabolism of glucose in tissues, a significant amount of energy necessary for the life of the organism is released.

    Hypertonic 10% solution glucose increases osmotic blood pressure, improves metabolism, increases myocardial contractility, improves antitoxic liver function, dilates blood vessels, increases diuresis.
    Pharmacokinetics:It is absorbed completely by the body, the kidneys are not excreted (the appearance in the urine is a pathological sign).
    Indications:

    5% glucose solution: hypoglycemia; insufficiency of carbohydrate nutrition; rapid replenishment of fluid volume in cellular, extracellular and general dehydration; component of blood and anti-shock fluids.

    10% glucose solution: hypoglycemia, infectious diseases, hepatitis, dystrophy and atrophy of the liver, cardiac decompensation, hemorrhagic diathesis, toxicinfection, intoxication (poisoning with drugs, hydrocyanic acid and its salts, carbon monoxide, aniline, arsenic hydrogen, phosgene, etc.), shock and collapse. Partial or complete parenteral nutrition.

    For the preparation of drugs for intravenous administration.
    Contraindications:Hypersensitivity, hyperglycemia, hyperhydration, hyperosmolar coma, hyperlactatemia, postoperative disorders of glucose utilization, circulatory disorders threatening edema of the brain and lungs, cerebral edema, pulmonary edema, acute left ventricular failure.
    Carefully:

    Decompensated chronic heart failure, chronic renal failure (oligo-, anuria), hyponatremia,diabetes.

    Dosing and Administration:

    5% glucose solution administered subcutaneously (500 ml) intravenously at a rate of 150 drops / min with a maximum daily dose of 2000 ml, and the rectum enemas, infusion of 300-500 mL.

    10% glucose solution Enter only intravenously up to 60 drops / min (3 ml / kg / h), the maximum daily dose of 1000 ml.

    Intravenously streamwise 10-50 ml of 5 and 10% solutions.

    In adults with a normal metabolism, the daily dose of glucose administered should not exceed 4-6 g / kg / day, i.e. about 250-450 g / day (with a decrease in the metabolic rate, the daily dose is reduced to 200-300 g), while the volume of injected liquid is 30-40 ml / kg / day.

    Children for parenteral nutrition along with fats and amino acids on the first day, 6 g of glucose / kg / day, followed by up to 15 g / kg / day. When calculating the dose of glucose with the introduction of 5 and 10% solutions, the permissible volume of the injected fluid should be taken into account: for children with a weight of 2-10 kg, 100-165 ml / kg / day, for children with a weight of 10-40 kg, 45-100 ml / kg / day.

    Side effects:

    Hyperglycemia, fever, hypervolemia, acute left ventricular failure, at the injection site - mild pain, development of infection, sometimes thrombophlebitis.

    With repeated administration of the solution, violations of the functional state of the liver and depletion of the insulin apparatus of the pancreas are possible.

    Overdose:

    In case of an overdose, the drug should be withdrawn and symptomatic therapy should be performed.

    With a strong increase in sugar in the blood to carry out insulin therapy.

    With hyperhydration, carry out osmotherapy.

    Interaction:

    Possible invisible chemical or therapeutic incompatibility.

    When adding other drugs to the solution, it is necessary to visually check compatibility.

    Special instructions:

    A glucose solution can not be used in conjunction with blood, canned ACD.

    Infusions of large amounts of glucose can be dangerous in patients who have a large loss of electrolytes. Follow the electrolyte balance! To increase osmolarity, 5% glucose solution can be combined with 0.9% sodium chloride solution.

    It is necessary to monitor the level of glucose in the blood.

    For more complete and rapid assimilation of glucose, it is possible to inject 4-5 units of insulin subcutaneously, at the rate of 1 unit of insulin per 4-5 g of glucose.

    Form release / dosage:Solution for infusions, 5% and 10%.
    Packaging:

    For 100, 250, 500 and 1000 ml of a 5% solution or 250 and 500 ml of 10% solution for infusion in polymeric containers.

    Containers of 70 pieces with a capacity of 100 ml, or 32 pieces with a capacity of 250 ml, or 20 pieces with a capacity of 500 ml,or 10 pieces with a capacity of 1000 ml are placed in a box of corrugated cardboard with 3-5 instructions for use (for hospitals).

    Storage conditions:

    Store in a place protected from light and inaccessible to children, at a temperature of 5 to 25 ° C.

    Freezing of the drug during transportation (provided the container is tight) is not a contraindication to its use. After freezing, the containers in the shipping container should be allowed to stand at room temperature until completely thawed (before mixing, shake the mixture in a container).

    Shelf life:

    2 years.

    Do not use after the expiration date.

    Terms of leave from pharmacies:On prescription
    Registration number:P N000771 / 01
    Date of registration:16.01.2008
    Expiration Date:Unlimited
    The owner of the registration certificate:RESTER, CJSC RESTER, CJSC Russia
    Manufacturer: & nbsp
    Information update date: & nbsp21.04.2017
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