Glucose Brown - instructions for use, dose, side effects, contraindications

Active substance:
Glucose monohydrate (dextrose monohydrate)	55.00 grams
(corresponding to anhydrous glucose)	50.00 grams
Excipient:
Water for injections	up to 1000 ml

Physico-chemical characteristics:

Carbohydrate content	50 g / l
Energy value	837 kJ / l (200 kcal / l)
Theoretical osmolality	278 mOsm / l
pH	3,5-5,5

Description:A clear, colorless solution.

Pharmacotherapeutic group:Solvent

ATX: & nbsp

B.05.C Irrigation solutions

V.06.D Other medications for nutrition

V.04.C Other diagnostic preparations

Pharmacodynamics:

Dextrose solutions with low concentration are suitable solvents of the preparations, since glucose as a natural substrate for cells is completely metabolized.

Glucose is one of the most important sources of energy with an energy value of 17 kJ / g or 4 kcal / g.

Pharmacokinetics:

During the introduction of the solution in the first place dextrose enters the intravascular space with the subsequent transition to cells.

In the process of glycolysis, glucose is converted into pyruvate or lactate. Further, lactate can partially be involved in glucose metabolism through the reactions of the Corey cycle. Pyruvate is fully oxidized by oxygen to CO₂ and H₂O. Glucose oxidation products are excreted by the lungs (CO₂) and kidneys (H₂ABOUT).

Normally, glucose is not eliminated by the kidneys. In pathological conditions, such as diabetes mellitus, metabolic disorders with hyperglycemia,when the concentration of glucose in the blood exceeds 120 mg / 100 ml or 6.7 mmol / l, glucose is excreted by the kidneys (glucosuria).

Indications:

Solution for the dilution of physico-chemically compatible concentrates of electrolytes and other drugs.

Contraindications:

- Hyperglycemia, not corrected by the introduction of short-acting insulin in a dose of up to 6 U / hour;

- pronounced metabolic acidosis;

- hemorrhages in the brain and spinal cord.

If it is necessary to use large volumes, contraindications associated with a dose of dextrose and / or with an overload of volume may appear:

- hyperhydration;

- hypotonic dehydration.

Pregnancy and lactation:

A solution of 5% dextrose can be used as a solution for the dilution of other drugs during pregnancy and during breastfeeding.

Dosing and Administration:

Intravenous administration. The solution can be injected into the central or peripheral veins, depending on the properties of the dissolving drug. The volume is chosen based on the required concentration of the drug, which is diluted with 5% dextrose solution for intravenous administration, taking into account the maximum doses indicated below.

Adults and children from 14 years of age

The recommended daily dose

Up to 40 ml / kg of body weight / day, corresponding to 2 g of dextrose / kg of body weight / day. The maximum dose corresponds to the maximum daily intake of liquid.

The rate of administration

Up to 5 ml / kg of body weight / hour, which corresponds to 0.25 g of dextrose / kg body weight / hour. This rate is equivalent to 1.7 drops / kg body weight / min.

Children

The maximum daily dose in g dextrose / kg body weight is:

Premature neonates:	18 grams of dextrose / kg body weight
Completed newborns:	15 grams of dextrose / kg body weight
from 1 year to 2 years:	15 grams of dextrose / kg body weight
from 2 years to 5 years:	12 grams of dextrose / kg body weight
from 5 years to 10 years:	10 grams of dextrose / kg body weight
from 10 years to 14 years:	8 grams of dextrose / kg body weight

With the introduction of this drug must take into account the total daily intake of liquid. The following daily dose of liquid for children is recommended for parenteral administration:

1st day of life	60-120 ml / kg body weight / day
2 nd day of life	80 - 120 ml / kg body weight / day
3rd day of life	100 - 130 ml / kg of body weight / day
4th day of life	120-150 ml / kg body weight / day
5th day of life	140-160 ml / kg body weight / day
6th day of life	140 - 180 ml / kg of body weight / day
1 st month of life until stable growth:	140-170 ml / kg body weight / day
1 st month of life after achieving stable growth:	140-160 ml / kg body weight / day
from the 2nd month to the 12th month of life:	120-150 ml / kg body weight / day
2 nd year of life:	80 - 120 ml / kg body weight / day
from 2 years to 5 years:	80 - 100 ml / kg of body weight / day
from 5 years to 12 years:	60 - 80 ml / kg of body weight / day
from 12 years to 18 years:	50 - 70 ml / kg body weight / day

Side effects:

Should not occur when using the solution in accordance with this instruction.

Overdose:

Symptoms

Overdose can cause hyperhydration, electrolyte disorders, hyperglycemia, glucosuria and increased blood osmolarity up to hyperglycemic hyperosmolar coma.

Therapy and antidotes

Depends on the type and severity of the violations:

discontinuation of infusion, administration of electrolytes, diuretics or short-acting insulin (at the rate of 1 unit of short-acting insulin for 4-5 g of dextrose).

Interaction:

Since a 5% dextrose solution for intravenous infusions has an acidic reaction medium (pH <7), incompatibility may occur when mixed with other drugs.

Erythrocyte mass should not be mixed with a solution of dextrose, tk. this can lead to pseudoagglutination.

Special instructions:

Patient monitoring should include regular monitoring of blood glucose concentration, water balance, electrolyte concentration in plasma - in particular, potassium - and acid-base balance.

Due to the potential risk of pseudoagglutination, dextrose solutions should not be administered using the same infusion equipment, or simultaneously, before or after a blood transfusion.

Bottle for single use. Remaining unused quantities of the drug are subject to destruction. Do not reuse bottles with the remaining contents.

The solution is to be used only if it is transparent, does not contain visible mechanical inclusions, the bottle and the cap are not damaged.

Effect on the ability to drive transp. cf. and fur:

The drug does not affect the ability to drive vehicles, mechanisms, as well as engage in potentially hazardous activities that require increased concentration and speed of psychomotor reactions.

Form release / dosage:Solution for infusions, 5%.

Packaging:

For 100 ml, 250 ml, 500 ml and 1000 ml in polyethylene bottles (European Pharmacopoeia).

For 20 bottles of 100 ml or 10 bottles of 250 ml, 500 ml or 1000 ml with instructions for use in a cardboard box (for hospitals).

Storage conditions:

Store at a temperature not exceeding 25 ° C.

Keep out of the reach of children.

Shelf life:

3 years.

Do not use after the expiry date printed on the package.

Terms of leave from pharmacies:For hospitals

Registration number:LS-001477

Date of registration:13.03.2012

Expiration Date:Unlimited

The owner of the registration certificate:B. Brown Mehlungen AGB. Brown Mehlungen AG Germany

Manufacturer: & nbsp

B. BRAUN MELSUNGEN, AG Germany

B. BRAUN MEDICAL, S.A. Spain

Representation: & nbspB. Brown Medikal, Open CompanyB. Brown Medikal, Open Company

Information update date: & nbsp22.04.2017

Illustrated instructions

Instructions

Glucose Brown (Glucose Braun)