Active substanceDextroseDextrose
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  • Dosage form: & nbspsolution for infusions
    Composition:

    Active substance:

    Dextrose (Dextrose monohydrate in terms of anhydrous)

    50 grams

    Excipients:

    Sodium chloride

    0.26 g

    Water for injections

    up to 1 liter

    Description:

    Colorless, clear liquid.

    Pharmacotherapeutic group:Nutrition carbohydrate remedy
    ATX: & nbsp

    B.05.C   Irrigation solutions

    V.06.D   Other medications for nutrition

    V.04.C   Other diagnostic preparations

    Pharmacodynamics:

    Glucose increases oxidation-reduction processes in the body, improves the antitoxic function of the liver, covers part of the energy expenditure of the body, as it is a source of easily assimilated carbohydrates.

    5% glucose solution is isotonic. With the metabolism of glucose in tissues, a significant amount of energy is released, which is necessary for the vital functions of the organism.

    The solution is quickly removed from the vascular system and only temporarily increases the volume of fluid circulating in the vessels.

    Pharmacokinetics:

    It is absorbed completely by the body, the kidneys are not excreted (the appearance in the urine is a pathological sign).

    Indications:

    Hypoglycemia, insufficiency of carbohydrate nutrition, toxicinfection, intoxications in liver diseases (hepatitis, cirrhosis, hepatic coma), hemorrhagic diathesis; cellular and general dehydration (vomiting, diarrhea, postoperative period); collapse, shock; for the dilution of medicinal products.

    Contraindications:

    Hyperglycemia, diabetes mellitus, hypersensitivity, hyperlactacidemia, hyperhydration, postoperative disorders of glucose utilization; edema of the brain, pulmonary edema, acute left ventricular failure, hyperosmolar coma.

    Carefully:

    Decompensated heart failure, chronic renal failure (oligo-, anuria), hyponatremia.

    Pregnancy and lactation:


    Dosing and Administration:

    The isotonic glucose solution (5%) is administered subcutaneously, intravenously drip, and also into the rectum in enemas, dripping 300-500 ml each.

    Intravenous dropwise 5% glucose solution is administered at a maximum rate of up to 7 ml (150 cap / min) (400 ml / h); the maximum daily intake for adults is 2 liters.

    In adults with normal metabolism, the daily dose of glucose administered should not exceed 4-6 g / kg, i.e. about 250-450 g (with a decrease in the metabolic rate, the daily dose is reduced to 200-300 g), while the daily volume of the injected liquid is 30-40 ml / kg.

    Children for parenteral nutrition along with fats and amino acids on the first day, 6 g glucose / kg / day, followed by up to 15 g / kg / day. When calculating the dose of glucose with the introduction of 5% glucose solution, you must take into account the permissible volume of the injected fluid: for children with a body weight of 2-10 kg - 100-165 ml / kg / day, children with a body weight of 10-40 kg - 45-100 ml / kg / day.

    Rate of administration: with a normal metabolic state, the maximum rate of glucose administration to adults is 0.25-0.5 g / kg / h (with metabolic rate, the rate of administration is reduced to 0.125-0.25 g / kg / h). In children, the rate of glucose administration should not exceed 0.5 g / kg / h; which is 5 ml of solution - about 10 ml / min or 200 cap / min (20 cap = 1 ml).

    For more complete and rapid assimilation of glucose, insulin can be administered subcutaneously at a rate of 1 unit of insulin per 4-5 g of glucose.

    Watch the water-electrolyte balance!

    It is necessary to control the level of sugar in the blood.

    Side effects:

    Hypervolaemia, acute left ventricular failure.

    With repeated administration of the solution, violations of the functional state of the liver and depletion of the insulin apparatus of the pancreas are possible.

    Light pain in places of injection, sometimes thrombophlebitis.

    Overdose:

    Symptoms: hyperglycemia, glucosuria, hyperglycemic hyperosmolar coma, hyperhydration, disturbance of water-electrolyte balance.

    Treatment: stop the introduction of glucose, introduce short-acting insulin, symptomatic therapy.

    Interaction:

    When combined with other medicines, visuallymonitor compatibility (possible invisible pharmaceutical or pharmacodynamic incompatibility).

    Special instructions:
    Effect on the ability to drive transp. cf. and fur:

    No data available.

    Form release / dosage:Solution for infusions, 5%.
    Packaging:

    For 200 ml or 400 ml in bottles for blood, transfusion and infusion preparations. One bottle with instructions for use in a pack of cardboard.

    For hospitals: for 200 ml 15 or 28 bottles or 400 ml 15 bottles are placed in a box with gaskets and grids (sockets) without preliminary stacking, together with 5-15 instructions for use.

    Storage conditions:

    Store at a temperature of 5 to 30 ° C, out of the reach of children.

    Freezing the drug under the condition of maintaining the tightness of the bottle is not a contraindication to its use.

    Non-wetting of the inner surface of the bottle is not a contraindication to the use of the drug.

    Shelf life:

    2 years.

    Do not use after the expiration date.

    Terms of leave from pharmacies:On prescription
    Registration number:P N001824 / 01
    Date of registration:05.05.2008 / 14.01.2014
    Expiration Date:Unlimited
    The owner of the registration certificate:MICROGEN FGUP Scientific and Production Association MICROGEN FGUP Scientific and Production Association Russia
    Manufacturer: & nbsp
    Representation: & nbspMICROGEN FGUP Scientific and Production Association MICROGEN FGUP Scientific and Production Association Russia
    Information update date: & nbsp03.05.2017
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