Active substanceDextroseDextrose
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  • Dosage form: & nbspsolution for infusions
    Composition:

    Active substance:


    Dextrose monohydrate,

    in terms of dextrose

    50 g (for 5% solution)

    100 g (for a 10% solution)

    Excipients:


    Sodium chloride

    0.26 g;

    Hydrochloric acid 0.1 M, up to the pH value

    from 3.0 to 4.1;

    Water for Injection

    up to 1 liter.

    Description:5% and 10% solutions are colorless, clear liquid.
    Pharmacotherapeutic group:Nutrition carbohydrate remedy
    ATX: & nbsp

    B.05.C   Irrigation solutions

    V.06.D   Other medications for nutrition

    V.04.C   Other diagnostic preparations

    Pharmacodynamics:

    Participates in various metabolic processes in the body.

    The infusion of dextrose solutions partially replenishes the water deficiency. Dextrose, entering the tissue, phosphorylated, turning into glucose-6-phosphate, which is actively included in many parts of the body's metabolism.

    5% dextrose solution is isotonic with blood plasma.

    Hypertensive (10%) the solution raises osmotic blood pressure, increases diuresis.

    Theoretical osmolarity of 10% dextrose is 555 mOsm / l.

    Pharmacokinetics:

    It is absorbed completely by the body, the kidneys are not excreted (the appearance in the urine is a pathological sign).

    Indications:

    Hypoglycaemia, insufficiency of carbohydrate nutrition, toxicinfection, intoxications with liver diseases (hepatitis, dystrophy and atrophy of the liver, including liver failure), hemorrhagic diathesis, dehydration (vomiting, diarrhea, postoperative period), intoxication, collapse, shock.

    As a component of various blood-substituting and anti-shock fluids; for the preparation of solutions of drugs for intravenous administration.

    Contraindications:

    Hypersensitivity, hyperglycemia, hyperlactacidemia, hyperhydration, postoperative disorders of dextrose utilization; circulatory disorders, threatening edema of the brain and lungs, cerebral edema, pulmonary edema, acute left ventricular failure, hyperosmolar coma.

    Carefully:

    Decompensated chronic heart failure, chronic renal failure (oligo, anuria), hyponatremia, diabetes mellitus.

    Dosing and Administration:
    Intravenously drip - 5% solution injected at a maximum rate of up to 7 ml (150 cap / min) (400 ml / h); the maximum daily intake for adults is 2 liters.

    10% solution - up to 3 ml (60 cap) / min; the maximum daily intake for adults is 1 liter.

    Intravenously sprayed - 10 to 50 ml 5% or 10% solution.

    In adults with a normal metabolism, the daily dose of dextrose administered should not exceed 4 to 6 g / kg, i.e. about 250 to 450 g (with a decrease in the metabolic rate, the daily dose is reduced to 200-300 g), while the daily volume of the injected liquid is from 30 to 40 ml / kg.

    Children for parenteral nutrition, along with fats and amino acids, dextrose at a dose of 6 g / kg / day is administered on the first day, followed by up to 15 g / kg / day.

    To calculate the dose of dextrose with the administration of 5% and 10% solutions, you must take into account the permissible volume of the injected fluid: for children with a body weight of 2 to 10 kg - from 100 to 165 ml / kg / day; Children with a body weight of 10 to 40 kg - from 45 to 100 ml / kg / day.

    Rate of administration: at the normal state of metabolism, the maximum rate of dextrose administration to adults is from 0.25 to 0.5 g / kg / h (with a decrease in the intensity of the metabolism, the rate of administration is reduced to 0.125-0.25 g / kg / h). In children, the rate of dextrose administration should not exceed 0.5 g / kg / h, which is 5% solution of about 10 ml / min, or 200 cap / min (20 cap = 1 ml).

    For more complete assimilation of dextrose, administered in large doses, concurrently with it, short-acting insulin is administered at the rate of 1 unit of insulin per 4-5 g of dextrose.

    Patients with diabetes mellitus are administered dextrose under the control of its content in blood and urine.

    Side effects:Hypervolaemia, acute left ventricular failure.
    At the injection site - the development of infection, thrombophlebitis.
    Overdose:

    Symptoms: Hyperglycemia, glucosuria, hyperglycemic hyperosmolar coma; hyperhydration, disturbances of water-electrolyte balance.

    Treatment: to stop the introduction of dextrose, to introduce insulin, symptomatic therapy.

    Interaction:

    When combined with other drugs, it is necessary to visually control the pharmaceutical compatibility.

    Special instructions:

    For a more complete and rapid assimilation of dextrose, you can inject 4 to 5 units of short-acting insulin from the calculation of 1 unit of short-acting insulin per 4-5 g of dextrose.

    Form release / dosage:

    Solution for infusions, 5% and 10%.

    Packaging:

    200 ml or 400 ml in glass bottles for blood, transfusion and infusion preparations.

    1 bottle with instructions for use in a pack of cardboard.

    For 20, 24 or 28 bottles with a capacity of 250 ml or 15 bottles with a capacity of 450 ml with an equal number of instructions for use in a cardboard box with partitions (for hospitals).

    Storage conditions:
    At a temperature of 5 to 30 ° C.

    Freezing of the drug providedThe tightness of the bottle, as well as the non-wetting of the inner surface of its bottle, are not grounds for refusing to use it.

    Keep out of the reach of children.

    Shelf life:2 years.
    Do not use after the expiration date indicated on the label.
    Terms of leave from pharmacies:On prescription
    Registration number:P N003708 / 01
    Date of registration:22.10.2009 / 03.09.2014
    Expiration Date:Unlimited
    The owner of the registration certificate:Kursk Biofactory - BIOK, FKPKursk Biofactory - BIOK, FKP Russia
    Manufacturer: & nbsp
    Information update date: & nbsp21.04.2017
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