Active substanceDextroseDextrose
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  • Dosage form: & nbspsolution for infusions
    Composition:

    1000 ml of the solution contain:

    5% solution

    10% solution

    Active substance:

    Dextrose (glucose) monohydrate

    55 grams

    110 g

    (corresponds to anhydrous dextrose)

    50 grams

    100 g

    Excipients:

    Sodium chloride

    0.26 g

    0.26 g

    Water for Injection

    up to 1000 ml

    up to 1000 ml

    Physico-chemical characteristics:

    Theoretical osmolality:

    5% solution

    286 mOsm / l

    10% solution

    564 mOsm / l

    Caloric value:

    5% solution

    200 kcal/l (835 kJ)/l)

    10% solution

    400 kcal/l (1675 kJ)/l)

    pH

    3,0-5,5

    Description:A clear, colorless liquid.
    Pharmacotherapeutic group:nutrition carbohydrate remedy
    ATX: & nbsp

    B.05.C   Irrigation solutions

    V.06.D   Other medications for nutrition

    V.04.C   Other diagnostic preparations

    Pharmacodynamics:

    Participates in various metabolic processes in the body.

    The infusion of dextrose solutions partially replenishes the water deficiency. Dextrose, entering the tissue, phosphorylated, turning into glucose-6-phosphate, which is actively included in many parts of the body's metabolism.

    5% dextrose solution is isotonic with blood plasma. Hypertensive (10%) the solution raises osmotic blood pressure, increases diuresis.

    Pharmacokinetics:

    It is absorbed completely by the body, the kidneys are not excreted (the appearance in the urine is a pathological sign).

    Indications:

    Hypoglycemia, insufficiency of carbohydrate nutrition, toxicinfection, intoxications in liver diseases (hepatitis, dystrophy and atrophy of the liver, incl.hepatic insufficiency), hemorrhagic diathesis, dehydration (vomiting, diarrhea, postoperative period), intoxication, collapse, shock.

    Contraindications:

    Hypersensitivity, hyperglycemia, hyperlactacidemia, hyperhydration, postoperative disorders of dextrose utilization; circulatory disorders that threaten edema of the brain, pulmonary edema, acute left ventricular failure, hyperosmolar coma.

    Carefully:

    Decompensated chronic heart failure, chronic renal failure (oligo, anuria), hyponatremia, diabetes mellitus.

    Pregnancy and lactation:

    5% glucose solution can be used on indications during pregnancy and during lactation.

    At present, sufficient clinical data on the use of 10% glucose solution during pregnancy and during lactation there is no, therefore it is possible to use it in pregnant women and during lactation only in cases when the expected benefit from treatment with the drug exceeds the possible risk of complications.

    Dosing and Administration:

    Intravenously drip.

    5% solution injected at a maximum rate of up to 7 ml (150 cal / min) (400 ml / h); the maximum daily intake for adults is 2 liters.

    10% solution - up to 3 ml (60 cap) / min; the maximum daily intake for adults is 1 liter.

    Intravenously streamwise - 10-50 ml 5% and 10% solutions.

    In adults The daily dose of dextrose administered should not exceed 4 to 6 g / kg, i.e. about 250-450.

    In metabolic disorders that occur after surgery, trauma, or hypoxia, glucose oxidation is impaired. In these cases, the daily dose is reduced to 200-300 g, while the daily volume of the injected liquid should be 30-40 ml / kg.

    Children for parenteral nutrition, along with fats and amino acids on the first day, glucose is administered in a dose of 6 g glucose / kg / day, then - up to 15 g / kg / day.

    To calculate the dose of glucose with the introduction of 5% and 10% solutions you need to take into account the permissible volume of the injected fluid: for children with a body weight of 2 to 10 kg - 100-165 ml / kg / day; Children with a body weight of 10-40 kg - 45-100 ml / kg / day.

    The rate of administration: with undisturbed metabolism, the maximum rate of dextrose administration to adults is 0.25-0.5 g / kg / h, with a metabolic disorder (a decrease in metabolic rate, for example, after surgery or trauma, with hypoxia), the rate of administration is reduced to 0.125- 0.25 g / kg / h.In children, the rate of dextrose administration should not exceed 0.5 g / kg / h, which is 5% solution of about 10 ml / min, or 200 cap / min (20 cap = 1 ml).

    For more complete assimilation of dextrose, administered in large doses, concurrently with it, short-acting insulin is administered at the rate of 1 unit of insulin per 4-5 g of dextrose.

    Patients with diabetes mellitus are administered dextrose under the control of its content in blood and urine.

    Side effects:

    Hypervolaemia, acute left ventricular failure.

    At the injection site - the development of infection, thrombophlebitis.

    Overdose:

    Symptoms: Hyperglycemia, glucosuria, hyperglycemic hyperosmolar coma; hyperhydration, violation of water-electrolyte balance.

    Treatment: to stop the introduction of dextrose, to introduce insulin, symptomatic therapy.

    Interaction:

    When combined with other drugs, it is necessary to visually control the pharmaceutical compatibility.

    Special instructions:

    For more complete assimilation of dextrose at the same time it can be injected subcutaneously with 4 to 5 units of short-acting insulin per 1 ED of short-acting insulin per 4-5 g of dextrose.

    The drug can be used as a solution for intravenous infusion,to which can be added compatible concentrated solutions of electrolytes and other drugs.

    Freezing during transportation is allowed.

    Effect on the ability to drive transp. cf. and fur:

    The drug does not affect the ability to drive vehicles, mechanisms, as well as engage in potentially dangerous activities that require increased concentration and speed of psychomotor reactions.

    Form release / dosage:

    Solution for infusions, 5% and 10%.

    Packaging:

    250 ml and 500 ml in polyethylene bottles that meet the requirements of the European Pharmacopoeia for polyethylene for parenteral preparations. Vials are of two types. Type A - a bottle with a self-falling body and a volume scale on the side surface. Type B - a bottle with a self-falling body and without a volume scale. On the bottles are welded polyethylene caps of one of two types. Type I - polyethylene cap with two separate ports in the upper part, under which there is a rubber disc; each of the ports is individually sealed with foil. Type II is a polyethylene cap with one port in the upper part, under which there is a rubber disc, and with a control ring of the first opening.

    15, 12 or 10 bottles of 250 ml, 12 or 10 bottles of 500 ml with an equal number of instructions for medical use in a cardboard box (for hospitals).

    1 bottle of 250 ml or 500 ml with instructions for medical use in a cardboard pack.

    15, 12 or 10 bottles of 250 ml or 12 or 10 bottles of 500 ml with an equal number of bilateral cannula for mixing the solutions of "Ecoflac Mix" or plugs for infusion bottles "Ecopine", each in a sterile package for single use, in a cardboard box. The box contains instructions on the medical use of the drug and instructions on how to use the cannula for mixing EcoFlac Mix solutions or plugs for Ecopin infusion bottles in an amount corresponding to the number of bottles (for hospitals).

    15, 12 or 10 bottles of 250 ml or 12 or 10 bottles of 500 ml with an equal number of systems for infusion of "Intrafix Safe Safe" in a length of 180 cm or 220 cm, each in a sterile package for single use, in a cardboard box. The box contains instructions on the medical use of the drug and instructions for the use of Intrafix SafeSet infusion systems in an amount corresponding to the number of bottles (for hospitals).

    Storage conditions:

    Store at temperatures between 2 and 30 ° C.

    Keep out of the reach of children.

    Shelf life:

    3 years.

    Do not use after the expiration date printed on the package.

    Terms of leave from pharmacies:On prescription
    Registration number:P N003917 / 01
    Date of registration:29.10.2009 / 25.06.2013
    The owner of the registration certificate:GEMATEK, LLC GEMATEK, LLC Russia
    Manufacturer: & nbsp
    Information update date: & nbsp12.01.2016
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