Active substanceDextroseDextrose
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  • Dosage form: & nbspsolution for infusions
    Composition:

    Dextrose monohydrate in terms of anhydrous 50.0 or 100.0 g, sodium chloride 0.26 g, 1 M hydrochloric acid solution to pH 3.0-5.5, water for injection up to 1 liter.

    Description:A clear, colorless liquid.
    Pharmacotherapeutic group:Nutrition carbohydrate remedy
    ATX: & nbsp

    B.05.C   Irrigation solutions

    V.06.D   Other medications for nutrition

    V.04.C   Other diagnostic preparations

    Pharmacodynamics:

    Glucose increases oxidation-reduction processes in the body, improves the antitoxic function of the liver, covers part of the energy expenditure of the body.

    The infusion of glucose solutions quickly replenishes the water deficiency. Glucose entering the tissues is phosphorylated, turning into glucose-6-phosphate, which is actively included in many parts of the body's metabolism.

    Isotonic 5% glucose solution has detoxication and metabolic action, restores the volume of circulating blood, is a source of easily digestible nutrient. With the metabolism of glucose in tissues, a significant amount of energy necessary for the life of the organism is released.

    Hypertensive 10% glucose solution increases osmotic blood pressure, improves metabolism, increases myocardial contractility, improves antitoxic liver function, dilates blood vessels, increases diuresis.

    Pharmacokinetics:

    It is absorbed completely by the body, the kidneys are not excreted (the appearance in the urine is a pathological sign).

    Indications:

    Hypoglycemia; insufficiency of carbohydrate nutrition; poisoning, intoxication liver diseases (hepatitis, dystrophy and atrophy of the liver, including hepatic failure), hemorrhagic diathesis, dehydration (vomiting, diarrhea, postoperative period); intoxication; collapse, shock.

    As a component of various blood-substituting and anti-shock fluids; for the preparation of solutions of drugs for intravenous administration.

    Contraindications:

    Hypersensitivity, hyperglycemia, hyperhydration, hyperosmolar coma, giperlaktatsidemiya, postoperative glucose utilization disorders, circulatory disorders, cerebral edema and threatening lung, brain edema, pulmonary edema, acute left ventricular failure.

    Carefully:

    Decompensated chronic heart failure, chronic renal failure (oligo, anuria), hyponatremia, diabetes mellitus.

    Dosing and Administration:

    5% glucose solution administered subcutaneously (500 ml) intravenously at a rate of 150 drops / min with a maximum daily dose of 2000 ml, and the rectum enemas, infusion of 300-500 mL.

    10% glucose solution Enter only intravenously up to 60 drops / min (3 ml / kg / h), the maximum daily dose of 1000 ml.

    Intravenously spray 10-50 ml of 5 and 10% solutions.

    In adults with a normal metabolism, the daily dose of glucose administered should not exceed 4-6 g / kg / day, i.e. about 250-450 g / day (with a decrease in the metabolic rate, the daily dose is reduced to 200-300 g), while the volume of the injected liquid is 30-40 ml / kg / day.

    Children for parenteral nutrition, along with fats and amino acids, on the first day, 6 g of glucose / kg / day, followed by up to 15 g / kg / day. When calculating the dose of glucose with the introduction of 5 and 10% solutions, the permissible volume of the injected fluid should be taken into account: for children with a weight of 2-10 kg, 100-165 ml / kg / day, for children with a weight of 10-40 kg, 45-100 ml / kg / day.

    Side effects:

    Hyperglycemia, fever, hypervolemia, acute left ventricular failure, at the injection site - mild pain, development of infection, sometimes thrombophlebitis.

    With repeated administration of the solution, violations of the functional state of the liver and depletion of the insulin apparatus of the pancreas are possible.

    Overdose:

    In case of an overdose (hyperglycemia), the drug should be withdrawn and symptomatic therapy should be performed.With an increase in glucose in the blood of more than 7 mmol / l, conduct insulin therapy.

    With hyperhydration, carry out osmotherapy.

    Interaction:

    When combined with other drugs, it is necessary to visually check compatibility.

    Special instructions:

    A glucose solution can not be used in conjunction with blood, canned ACD [anticoagulant acid-citrate-glucose (dextrose)].

    Infusion of large amounts of glucose can be dangerous in patients who have a large loss of electrolytes.

    Follow the electrolyte balance! To increase osmolarity 5% a glucose solution can be combined with 0.9% solution of sodium chloride.

    It is necessary to monitor the level of glucose in the blood.

    For more complete and rapid assimilation of glucose, it is possible to inject 4-5 units of insulin subcutaneously, at the rate of 1 unit of insulin per 4-5 g of glucose.

    Form release / dosage:

    Solution for infusions, 5% and 10%.

    Packaging:

    200, 250, 400, 500 ml into polymeric containers for single-use infusion solutions.

    Containers with solution are packed:

    - for hospitals: in one package of polyethylene film or polyethylene-polyamide film.

    30 containers of 200 ml,

    24 containers of 250 ml,

    15 containers of 400 ml or

    12 containers of 500 ml with an equal number of instructions for use are placed in a box of corrugated cardboard;

    - for sale through the pharmacy network: in two bags of polyethylene film or polyethylene-polyamide film, the instructions for medical use are placed in the outer.

    30 containers of 200 ml,

    24 containers of 250 ml,

    15 containers of 400 ml or

    12 containers of 500 ml each are placed in a box of corrugated cardboard.

    Storage conditions:

    Store in a dry place at a temperature of no higher than 25 ° C.

    Keep out of the reach of children.

    Freezing of the drug during transportation (provided the container is not leaking) is not a contraindication to the use. After freezing, keep the containers in the shipping container at room temperature until completely thawed, before shaking, mix the solution in the container with shaking.

    Shelf life:2 years.
    Do not use after the expiration date.
    Terms of leave from pharmacies:On prescription
    Registration number:LSR-008111/08
    Date of registration:14.10.2008 / 08.07.2015
    Expiration Date:Unlimited
    The owner of the registration certificate:Anzhero-Sudzhensky Chemical-Pharmaceutical Plant, LLC Anzhero-Sudzhensky Chemical-Pharmaceutical Plant, LLC
    Manufacturer: & nbsp
    Information update date: & nbsp21.04.2017
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