Glucose - instructions for use, dose, side effects, contraindications

Participates in various metabolic processes in the body, enhances oxidation-reduction processes in the body, improves the antitoxic function of the liver.

The infusion of dextrose solutions partially replenishes the water deficiency. Dextrose, entering the tissue, phosphorylated, turning into glucose-6-phosphate, which is actively included in many parts of the body's metabolism.

5% dextrose solution has detoxification, metabolic action, it is a source of valuable easily assimilated nutrient. With the metabolism of dextrose in tissues, a significant amount of energy necessary for the vital activity of the body is released.

Pharmacokinetics:

It is absorbed completely by the body, the kidneys are not excreted (the appearance in the urine is a pathological sign).

Indications:

Hypoglycemia, insufficiency of carbohydrate nutrition, toxicinfection, intoxications in liver diseases (hepatitis, dystrophy and atrophy of the liver, incl.hepatic insufficiency), hemorrhagic diathesis; dehydration (vomiting, diarrhea, postoperative period); intoxication; collapse, shock.

As a component of various blood-substituting and anti-shock fluids; for the preparation of drug solutions (LS) for intravenous administration (IV).

Contraindications:

Hypersensitivity, hyperglycemia, hyperlactacidemia, hyperhydration, postoperative disorders of glucose utilization; circulatory disorders, threatening edema of the brain and lungs, cerebral edema, pulmonary edema, acute left ventricular failure, hyperosmolar coma.

Carefully:

Diabetes mellitus, decompensated heart failure, chronic renal failure (oligo-, anuria), hyponatremia.

Pregnancy and lactation:

Use during pregnancy and lactation is possible by appointment of a doctor.

Dosing and Administration:

Intravenous (IV) dropwise, 5% solution is administered at a maximum rate of up to 7 ml (150 cap / min) (400 ml / h); the maximum daily intake for adults is 2 liters.

In / in a jet - 10-50 ml of a 5% solution.

In adults with a normal metabolism, the daily dose of dextrose administered should not exceed 4-6 g / kg, i.e.about 250-450 g (with a decrease in the metabolic rate, the daily dose is reduced to 200-300 g), while the daily volume of the injected liquid is 30-40 ml / kg.

Children for parenteral nutrition, along with fats and amino acids, 6 g of dextrose / kg / day are administered on the first day, followed by up to 15 g / kg / day. When calculating the dose of dextrose with the administration of 5% and 10% solutions of dextrose, you must take into account the permissible volume of the injected fluid: for children with a body weight of 2-10 kg - 100-165 ml / kg / day, children with a body weight of 10-40 kg - 45 -100 ml / kg / day.

The rate of administration: in the normal state of metabolism, the maximum rate of dextrose administration to adults is 0.25-0.5 g / kg / h (with a decrease in the intensity of the metabolism, the rate of administration is reduced to 0.125-0.25 g / kg / h). In children, the rate of dextrose administration should not exceed 0.5 g / kg / h, which is about 10 ml / min or 200 cap / min for a 5% solution (20 cap = 1 ml).

For more complete assimilation of dextrose, administered in large doses, simultaneously with her, insulin is prescribed at the rate of 1 unit of insulin per 4-5 g of dextrose.

Diabetic patients with dextrose are administered under the control of its content in the blood and urine.

Side effects:

Hypervolaemia, acute left ventricular failure.

At the injection site - the development of infection, thrombophlebitis.

Overdose:

Symptoms: hyperglycemia, glucosuria, hyperglycemic hyperosmolar coma, hyperhydration, disturbance of water-electrolyte balance.

Treatment: stop the introduction of glucose, introduce insulin, symptomatic therapy.

Interaction:

When combined with other drugs, you need to visually check for compatibility (possibly invisible pharmaceutical or pharmacodynamic incompatibility).

Special instructions:

For more complete and rapid assimilation of dextrose, it is possible to administer 4-5 units of insulin subcutaneously, at the rate of 1 unit of insulin per 4-5 g of dextrose.

Effect on the ability to drive transp. cf. and fur:

The use of the drug does not affect the management of vehicles and the maintenance of machines and mechanisms that require concentration of attention.

Form release / dosage:Solution for infusions, 5%.

Packaging:

For 200, 250, 400, 500, 1000, 2000 ml into containers are polyvinylchloride.

Each container with a preparation of 200, 250, 400, 500, 1000, 2000 ml is packed in two plastic bags (inner and outer bags); or each container with a preparation of 200, 250, 400, 500, 1000, 2000 ml is packed in a polyethylene (inner) bag.

One container is packed in a package of a combined laminated film based on aluminum foil (outer package).

For hospitals:

Each container with a preparation of 200, 250, 400, 500 ml is packed in a polyethylene (inner) bag. 2, 3, 4, 5 containers are packed in a package of a combined multi-layer film based on aluminum foil (outer bag);

Each container with a preparation of 1000, 2000 ml is packed in a polyethylene (inner) bag. 2, 3, 4 containers are packed in a package of a combined multi-layer film based on aluminum foil (outer bag);

containers with a preparation of 200, 250, 400, 500 ml for 1, 2, 3, 4, 5 pieces are packed in a package of a combined multilayer film based on aluminum foil (outer bag);

containers with a preparation of 1000, 2000 ml for 1, 2, 3, 4 pieces are packed in a package of a combined multilayer film based on aluminum foil (outer package).

Instructions for the medical use of the drug:

- put in an outer bag when packing containers with the drug in plastic bags;

- applied to a package or package label when packaging containers with a preparation in an outer bag of a combined multilayer film based on aluminum foil;

- they are put in transport packaging - when packing containers with the drug in external packages of a combined multilayer film based on aluminum foil, in an amount equal to the number of containers with the drug (for hospitals).

Storage conditions:

In a dry, the dark place at a temperature of 5 to 25 ° C.

Keep out of the reach of children.

Shelf life:

3 years.

Do not use after expiry date.

Terms of leave from pharmacies:On prescription

Registration number:P N000209 / 02

Date of registration:29.07.2011

The owner of the registration certificate:SYNTHESIS, JSC Joint-stock Kurgan Society of Medical Preparations and Products SYNTHESIS, JSC Joint-stock Kurgan Society of Medical Preparations and Products Russia

Manufacturer: & nbsp

SYNTHESIS, OJSC Russia

Representation: & nbspSYNTHESIS JSC Joint-Stock Kurgan Society of Medical Preparations and Products SYNTHESIS JSC Joint-Stock Kurgan Society of Medical Preparations and Products Russia

Information update date: & nbsp12.01.2016

Illustrated instructions

Instructions

Glucose (Glucose)