Active substanceDextroseDextrose
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  • Dosage form: & nbspsolution for infusions
    Composition:

    1 ml of the solution contains:

    active substance: dextrose monohydrate (in terms of dry matter) 50 mg;

    Excipients: solution of hydrochloric acid 0.1 M - to pH 3.0-4.1, sodium chloride 0.26 mg, water for injection up to 1 ml.

    Description:A clear, colorless liquid.
    Pharmacotherapeutic group:Nutrition carbohydrate remedy
    ATX: & nbsp

    B.05.C   Irrigation solutions

    V.06.D   Other medications for nutrition

    V.04.C   Other diagnostic preparations

    Pharmacodynamics:

    Participates in various metabolic processes in the body. The infusion of a 5% dextrose solution partially replenishes the water deficiency. Dextrose, entering the tissue, phosphorylated, turning into glucose-6-phosphate, which is actively included in many parts of the body's metabolism.

    5% the dextrose solution exerts detoxification, metabolic action, and is a source of valuable digestible nutrients.

    5% dextrose solution is isotonic with blood plasma. With the metabolism of dextrose in tissues, a significant amount of energy necessary for the vital activity of the body is released.

    Pharmacokinetics:It is absorbed completely by the body, the kidneys are not excreted (the appearance in the urine is a pathological sign).
    Indications:

    Hypoglycemia, insufficiency of carbohydrate nutrition, toxicoinfection, hemorrhagic diathesis, dehydration (vomiting, diarrhea, postoperative period); intoxication; collapse, shock.

    As a component of various blood substitutes and powder liquids; for the preparation of solutions of drugs for intravenous administration.

    Contraindications:

    Hypersensitivity, hyperglycemia, hyperlactacidemia, hyperhydration, postoperative disorders of glucose utilization; circulatory disorders, threatening edema of the brain and lungs, cerebral edema, pulmonary edema, acute left ventricular failure, hyperosmolar coma.

    Carefully:

    Diabetes mellitus, decompensated heart failure, chronic renal failure insufficiency (oligo-, anuria), hyponatremia.

    Pregnancy and lactation:

    Use during pregnancy and lactation is possible by appointment of a doctor.

    Dosing and Administration:

    Intravenously (intravenously) drip, 5% the solution is administered at a maximum rate of up to 7 ml (150 cap / min) (400 ml / h); the maximum daily intake for adults is 2 liters.

    In / in streaming - 10-50 ml of a 5% solution.

    In adults with normal metabolism, the daily dose of dextrose administered should not be exceed 4-6 g / kg, i.e. about 250-450 g (with a decrease in the metabolic rate, the daily dose is reduced to 200-300 g), while the daily volume of the injected liquid is 30-40 ml / kg.

    When calculating the dose of dextrose upon administration of 5% solution it is necessary to take into account the permissible volume of the injected liquid: for children with a body weight of 2-10 kg - 100-165 ml / kg / day, children with a body weight of 10-40 kg - 45-100 ml / kg / day.

    Rate of administration: at a normal state of metabolism, the maximum rate of dextrose administration to adults is 0.25-0.5 g / kg / h (with a decrease in the metabolic rate, the rate of administration is reduced to 0.125-0.25 g / kg / h).

    In children, the rate of dextrose administration should not exceed 0.5 g / kg / h, which is 1 ml / min or 200 cap / min (20 cap = 1 ml) for a 5% solution,

    For more complete assimilation of dextrose, administered in large doses, concomitantly with it prescribe insulin of short action at the rate of 1 unit of insulin per 4-5 g of dextrose.

    Diabetic patients with dextrose are administered under the control of its content in the blood and urine.

    Side effects:

    Ion balance disorders, hypervolemia, acute left ventricular failure.

    At the injection site - the development of infection, thrombophlebitis.

    Overdose:

    Symptoms: hyperglycemia, glucosuria, hyperglycemic hyperosmolar coma, hyperhydration, disturbance of water-electrolyte balance.

    Treatment: stop the introduction of glucose, introduce short-acting insulin, symptomatic therapy.

    Interaction:

    When combined with other drugs, it is necessary to visually check compatibility (possibly invisible pharmaceutical or pharmacodynamic incompatibility).

    Special instructions:

    For more complete and rapid assimilation of dextrose, it is possible to administer 4-5 U insulin, at the rate of 1 unit of insulin per 4-5 g of dextrose.

    5% the dextrose solution can be used as a base solution for dissolving and diluting physico-chemically compatible concentrates and drugs.

    Effect on the ability to drive transp. cf. and fur:

    The use of the drug does not affect the management of vehicles and the maintenance of machines and mechanisms that require concentration of attention.

    Form release / dosage:

    Solution for infusions, 5%.

    Packaging:

    For 100, 250 ml in bottles of high-density polyethylene of low density.

    The polyethylene bottle together with the instruction for use is put in a bag of polyethylene film and welded (it is allowed to have holes in the weld seam for air outlet from the polyethylene bag).

    Vials in packages with instructions for use are placed in a box of corrugated cardboard.

    Storage conditions:

    At a temperature of 5 to 30 ° C.

    Keep out of the reach of children.

    Shelf life:

    2 years.

    Do not use after the expiration date printed on the package.

    Terms of leave from pharmacies:On prescription
    Registration number:P N001186 / 02
    Date of registration:20.07.2009
    Expiration Date:Unlimited
    The owner of the registration certificate:MOSHIMFARM PREPARATES them. N.А.Semashko, OJSC MOSHIMFARM PREPARATES them. N.А.Semashko, OJSC Russia
    Manufacturer: & nbsp
    Representation: & nbspMOSHIMFARM PREPARATES them. NA Semashko OJSC MOSHIMFARM PREPARATES them. NA Semashko OJSC Russia
    Information update date: & nbsp21.04.2017
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