Active substanceDextroseDextrose
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  • Dosage form: & nbspsolution for infusions
    Composition:

    Active substances:


    Dextrose monohydrate, in terms of anhydrous

    100.0 g

    Excipients:


    Sodium chloride

    0.26 g

    0.1 M hydrochloric acid

    to pH 3,0-4,1

    Water for injections

    up to 1 liter

    Theoretical osmolality

    555 mOsm / l.

    Description:A clear, colorless liquid.
    Pharmacotherapeutic group:Nutrition carbohydrate remedy
    ATX: & nbsp

    B.05.C   Irrigation solutions

    V.06.D   Other medications for nutrition

    V.04.C   Other diagnostic preparations

    Pharmacodynamics:

    Participates in various metabolic processes in the body.

    The infusion of dextrose solutions partially replenishes the water deficiency. Dextrose, entering the tissue, phosphorylated, turning into glucose-6-phosphate, which is actively included in many parts of the body's metabolism.

    5% dextrose solution is isotonic with blood plasma. Hypertensive solutions (10%, 20%, 40%) increase the osmotic pressure of blood, increases diuresis. Theoretical osmolarity of a 10% dextrose solution is 555 mOsm / l.

    Pharmacokinetics:

    It is absorbed completely by the body, the kidneys are not excreted (the appearance in the urine is a pathological sign).

    Indications:

    Hypoglycemia, insufficiency of carbohydrate nutrition, toxicoinfection, intoxications in liver diseases (hepatitis, dystrophy and atrophy of the liver, including hepatic insufficiency), hemorrhagic diathesis; dehydration (vomiting, diarrhea,postoperative period); intoxication (poisoning with narcotic substances, hydrocyanic acid and its salts, carbon monoxide, aniline, arsenic hydrogen, phosgene, etc.); collapse, shock.

    As a component of various blood-substituting and anti-shock fluids; for the preparation of solutions of drugs for intravenous administration.

    Contraindications:Hypersensitivity, hyperglycemia, hyperlactacidemia, hyperhydration, postoperative disorders of glucose utilization; circulatory disorders that threaten edema of the brain and lungs; edema of the brain, pulmonary edema, acute left ventricular failure, hyperosmolar coma.
    Carefully:Decompensated chronic heart failure, chronic renal failure (oligo, anuria), hyponatremia, diabetes mellitus.
    Pregnancy and lactation:Possible application for indications.
    Dosing and Administration:Intravenously drip, the solution is administered at a maximum rate of up to 60 cap / min (3 ml / min); the maximum daily intake for adults is 1 liter.

    Intravenously struino - 10-50 ml.

    In adults with a normal metabolism, the daily dose of dextrose administered should not exceed 4-6 g / kg, i.e.about 250-450 g (with a decrease in the metabolic rate, the daily dose is reduced to 200-300 g), while the daily volume of the injected liquid is 30-40 ml / kg.

    Children for parenteral nutrition, along with fats and amino acids, 6 g of dextrose / kg / day are administered on the first day, followed by up to 15 g / kg / day.

    When calculating the dose of dextrose upon administration, it is necessary to take into account the permissible volume of the injected fluid: for children with a body weight of 2-10 kg, 100-165 ml / kg / day, for children with a body weight of 10-40 kg, 45-100 ml / kg / day.

    Rate of administration: at the normal state of metabolism, the maximum rate of administration to adults is 0.25-0.5 g / kg / h (with a decrease in the intensity of the metabolism, the rate of administration is reduced to 0.125-0.25 g / kg / h). In children, the rate of administration should not exceed 0.5 g / kg / h.

    For more complete assimilation of dextrose, administered in large quantities, concurrently with it, short-acting insulin is prescribed at the rate of 1 unit of short-acting insulin for 4-5 g of dextrose.

    Patients with diabetes mellitus are administered dextrose under the control of its content in blood and urine.

    Side effects:Hypervolaemia, acute left ventricular failure.
    At the injection site - the development of infection, sometimes thrombophlebitis.
    With repeated administration of the solution, violations of the functional state of the liver and depletion of the insulin apparatus of the pancreas are possible.
    Overdose:

    Symptoms: hyperglycemia, glucosuria, hyperglycemic hyperosmolar coma, hyperhydration, disturbance of water-electrolyte balance, enhancement of lipogenesis with increased production CO2, which leads to a sharp increase in the minute volume of respiration and, consequently, respiratory rate; fatty liver infiltration.

    Treatment: stop the introduction of dextrose, introduce short-acting insulin, symptomatic therapy.

    Interaction:

    Possible invisible pharmaceutical incompatibility. When adding other drugs to the solution, it is necessary to visually check compatibility.

    Special instructions:
    Infusions of large amounts of dextrose can be dangerous for patients who have a large loss of electrolytes.

    Follow the electrolyte balance!

    It is necessary to monitor the concentration of glucose in the blood.

    For a more complete and rapid assimilation of dextrose, it is possible to inject 4-5 units of insulin of short action subcutaneously, at the rate of 1 unit of short-acting insulin for 4-5 g of dextrose.

    Form release / dosage:

    Solution for infusions, 10%.

    Packaging:

    1) For 100, 200, 400 ml in bottles of glass.

    1 bottle with instructions for use in a pack of cardboard (for sale through a pharmacy network).

    It is allowed to put the text of instructions for use in a typographical way on a pack without enclosing instructions for the use of the medicinal product.

    36 packs of bottles with a capacity of 100 ml, 28 or 15 packs with bottles with a capacity of 250 ml and 15 packs of 450 ml bottles are placed in a box of cardboard for consumer packaging or in a box of corrugated cardboard.

    36 bottles with a capacity of 100 ml, 15, 28 bottles with a capacity of 250 ml or 15 bottles with a capacity of 450 ml, together with instructions for use in quantities corresponding to the number of primary packages in a box of corrugated (for hospitals).

    2) By 100, 200, 250, 300, 400, 500, 1000 ml into the polymeric containers.

    To implement through the pharmacy network, each polymer container is packed in a bag of transparent polyethylene film.

    44 polymer containers of 100 ml volume, 32 polymer containers of 200 ml volume, 28 polymer containers of 250 ml volume, 20 polymer containers of 300 ml volume, 16 polymer containers of 400 ml volume, 12 polymer containers of 500 ml,6 polymer containers of 1000 ml in bags of transparent polyethylene film (for sale through the pharmacy network) or without bags (for hospitals), along with instructions for medical use and guidance for use polymeric containers with an infusion solution, in quantity corresponding to the quantity polymeric containers, placed in a box of cardboard for consumer packaging or in a box of corrugated cardboard.

    Storage conditions:

    Keep out of the reach of children.

    Store in a dark place at a temperature of 5 to 25 ° C.

    For the preparation in a glass bottle, the non-wetting of the inner surface of the bottles is not a contraindication to the use of the preparation.

    For the preparation in a polymeric container, freezing during transport is permitted provided the container is hermetically sealed.

    Shelf life:

    3 years.

    Do not use after the expiration date.

    Terms of leave from pharmacies:On prescription
    Registration number:LP-000347
    Date of registration:22.02.2011 / 29.07.2016
    Expiration Date:Unlimited
    Date of cancellation:2016-02-22
    The owner of the registration certificate:MOSFARM, LLCMOSFARM, LLC
    Manufacturer: & nbsp
    Representation: & nbspMOSFARM, LLCMOSFARM, LLC
    Information update date: & nbsp21.04.2017
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