Glucose-E - instructions for use, dose, side effects, contraindications

Participates in various metabolic processes in the body. The infusion of dextrose solutions partially replenishes the water deficiency. Dextrose, entering the tissue, phosphorylated, turning into glucose-6-phosphate, which is actively included in many parts of the body's metabolism.

5% dextrose solution is isotonic with blood plasma.

10% hypertonic solution increases osmotic blood pressure, increases diuresis.

Theoretical osmolarity of 10% dextrose is 555 mOsm / l.

Pharmacokinetics:

It is absorbed completely by the body, the kidneys are not excreted (the appearance in the urine is a pathological sign).

Indications:

Hypoglycemia, insufficiency of carbohydrate nutrition, toxicoinfection, intoxications in liver disease (hepatitis, dystrophy and atrophy of the liver, including hepatic insufficiency), hemorrhagic diathesis.

As a component of various blood-substituting and anti-shock fluids: dehydration (vomiting, diarrhea, postoperative period); intoxication; collapse, shock.

For the preparation of solutions of medicinal means for intravenous administration.

Contraindications:

Hypersensitivity, hyperglycemia, hyperhydration, diabetic coma, incl. hyperlactacidemia, postoperative disorders of glucose utilization; circulatory disorders that threaten edema of the brain and lungs; edema of the brain, pulmonary edema, acute left ventricular failure, hyperosmolar coma.

Carefully:Decompensated chronic heart failure, chronic renal failure (oliguria, anuria), hyponatremia, diabetes, pregnancy and lactation.

Dosing and Administration:

Intravenously drip.

5% (isotonic) solution of Glucose-E is administered at a maximum rate of up to 7 ml (150 cap / min or 400 ml / h); the maximum daily intake for adults is 2 liters; 10% (hypertonic) solution of Glucose-E - up to 60 cap / min (3 ml / min); the maximum daily intake for adults is 1 liter.

In adults with a normal metabolism, the daily dose of dextrose administered should not exceed 4-6 g / kg, i.e. about 250-450 g (with a decrease in the metabolic rate, the daily dose is reduced to 200-300 g), while the daily volume of the injected liquid is 30-40 ml / kg.

Children for parenteral nutrition, along with fats and amino acids, 6 g of dextrose / kg / day are administered on the first day, followed by up to 15 g / kg / day. To calculate the dose of dextrose with the administration of 5% and 10% solutions of Glucose-E, you must take into account the permissible volume of the injected fluid: for children with a body weight of 2-10 kg is 100-165 ml / kg / day, children with a body weight of 10-40 kg - 45-100 ml / kg / day.

In the normal state of metabolism, the maximum rate of administration of Glucose-E adults - 0,25-0,5 g / kg / h (with a decrease in the intensity of the metabolism, the rate of administration is reduced to 0.125-0.25 g / kg / h). Children the rate of administration of Glucose-E should not exceed 0.5 g / kg / h; which is 5 ml of solution - about 10 ml / min or 200 cap / min (20 cap = 1 ml).

For a more complete assimilation of dextrose, administered in large doses, concomitantly with it prescribe short-acting insulin at the rate of 1 unit of short-acting insulin for 4-5 g of dextrose.

Patients with diabetes mellitus are administered dextrose under the control of its content in blood and urine.

Side effects:Hypervolaemia, acute left ventricular failure.

At the injection site - the development of infection, thrombophlebitis.

Overdose:

Symptoms: hyperglycemia, glucosuria, hyperglycemic hyperosmolar coma, hyperhydration, disturbance of water-electrolyte balance.

Treatment: stop the introduction of Glucose-E, introduce short-acting insulin, symptomatic therapy.

Interaction:

When combined with other drugs, it is necessary to visually check compatibility (possible invisible pharmaceutical incompatibility).

Special instructions:For a more complete and rapid assimilation of dextrose, it is possible to inject 4-5 units of insulin of short action subcutaneously, at the rate of 1 unit of short-acting insulin for 4-5 g of dextrose.

Form release / dosage:Solution for infusions, 5% and 10%.

Packaging:

For 100, 200, 400 and 500 ml in glass bottles for blood, transfusion and infusion preparations with a capacity of 100, 250, 450 and 500 ml, respectively.

For 100, 200, 250,400 and 500 ml in polymer bottles with a capacity of 100, 250 and 500 ml respectively.

By 100, 250, 500 ml into polymeric containers for infusion solutions of single use.

Each polyvinyl chloride container is placed in a bag of polyethylene film.

For 1 bottle with instructions for medical use put in a pack of cardboard box.

For 28 bottles with a capacity of 100 or 250 ml or 15 bottles with a capacity of 450 or 500 ml with an equal number of instructions for medical applications are placed in boxes of corrugated cardboard with gaskets and gratings "cores" of corrugated cardboard [for hospitals].

For 72 containers or bags with a container of 100 ml capacity, 34 containers or bags with a 250 ml container or 22 containers or a 500 ml container bag with an equal number of instructions for medical use are placed in corrugated cardboard boxes [for hospitals].

Storage conditions:

In the dark place at a temperature of 2 to 25 ° C.

Keep out of the reach of children.

Shelf life:

2 years.

Do not use after the expiration date indicated on the package.

Terms of leave from pharmacies:On prescription

Registration number:P N003088 / 01

Date of registration:17.03.2009 / 10.05.2012

Expiration Date:Unlimited

The owner of the registration certificate:ESKOM NPK, OAO ESKOM NPK, OAO Russia

Manufacturer: & nbsp

ESKOM NPK, OAO Russia

Representation: & nbspESKOM NPK, OAOESKOM NPK, OAO

Information update date: & nbsp02.05.2017

Illustrated instructions

Instructions

Glucose-E (Glucose-E)