Active substanceDextroseDextrose
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  • Dosage form: & nbspsolution for infusions
    Composition:

    Active substances: Dextrose (in terms of anhydrous) 50 g / 100 g / 200 g;

    ATExcipients: Mr.atria chloride 0.26 g, hydrochloric acid to pH 3.5-6.5, water for injection up to 1 liter.

    Description:

    Colorless transparent (5% and 10%),colorless or slightly yellowish transparent (20%) liquid.

    Pharmacotherapeutic group:Nutrition carbohydrate remedy
    ATX: & nbsp

    B.05.C   Irrigation solutions

    V.06.D   Other medications for nutrition

    V.04.C   Other diagnostic preparations

    Pharmacodynamics:

    Participates in various metabolic processes in the body, enhances redox processes in the body, improves the antitoxic function of the liver. The infusion of dextrose solutions partially replenishes the water deficiency. Dextrose, entering the tissue, phosphorylated, turning into glucose-6-phosphate, which is actively included in many parts of the body's metabolism.

    5% dextrose solution has detoxification, metabolic action, is a source of valuable easily assimilated nutrient. With the metabolism of dextrose in tissues, a significant amount of energy necessary for the vital activity of the body is released.

    Hypertensive solutions (10%, 20%) increase osmotic blood pressure, improve metabolism; increase myocardial contractility; improve the antitoxic function of the liver, dilate blood vessels, increase diuresis.

    Theoretical osmolarity of 10% dextrose is 555 mOsm / l, 20% - 1110 mOsm / l.

    Pharmacokinetics:

    It is absorbed completely by the body, the kidneys are not normally excreted (the appearance in the urine is a pathological sign).

    Indications:

    Hypoglycemia, insufficiency of carbohydrate nutrition, toxicinfection, intoxication in liver diseases (hepatitis, dystrophy and atrophy of the liver, including hepatic insufficiency), hemorrhagic diathesis; dehydration (vomiting, diarrhea, postoperative period); intoxication; collapse, shock.

    As a component of various blood-substituting and anti-shock fluids; for the preparation of solutions of drugs for intravenous administration.

    Contraindications:

    Hyperglycemia, diabetes mellitus, hypersensitivity, hyperlactacidemia, hyperhydration, postoperative disorders of glucose utilization; circulatory disorders that threaten edema of the brain and lungs; edema of the brain, pulmonary edema, acute left ventricular failure, hyperosmolar coma.

    Carefully:

    Decompensated heart failure, chronic renal failure (oligo-, anuria), hyponatremia.

    Dosing and Administration:

    The isotonic solution of dextrose (5%) is administered subcutaneously,intravenously (dropwise) at a maximum rate of up to 7.5 ml (150 cap / min) (400 ml / h); from 300-2000 ml of solution per day; hypertensive solution (10%) - up to 60 cap / min (3 ml / min); the maximum daily dose for adults is 1000 ml.

    20% solution - up to 30-40 cap / min (1.5-2 ml / min); the maximum daily intake for adults is 500 ml.

    Intravenously sprayed - 10-50 ml 5% and 10% solutions.

    In adults with a normal metabolism, the daily dose of dextrose administered should not exceed 4-6 g / kg / day, i.e. about 250-450 g / day (with a decrease in the metabolic rate, the daily dose is reduced to 200-300 g), while the volume of the injected liquid is 30-40 ml / kg / day.

    Children for parenteral nutrition, along with fats and amino acids, 6 g of dextrose / kg / day are administered on the first day, followed by up to 15 g / kg / day.

    When calculating the dose of dextrose with the administration of 5% and 10% solutions, it is necessary to take into account the permissible volume of the injected fluid: for children with a weight of 2-10 kg - 100-165 ml / kg / day, children with a weight of 10-40 kg - 45-100 ml / kg / day.

    The rate of administration: at the normal state of metabolism, the maximum rate of administration to adults is 0.25-0.5 g / kg / h (with a decrease in the intensity of the metabolism, the rate of administration is reduced to 0.125-0.25 g / kg / h). In children, the rate of administration should not exceed 0.5 g / kg / h, which is 5% for a solution - about 10 ml / min - 200 drops / min (20 drops = 1 ml).

    In cases of severe dehydration, 3-5 liters of isotonic solution of dextrose are possible.

    Patients with diabetes dextrose are administered under the control of sugar in the blood and urine.

    Side effects:

    Hyperglycemia, fever, hypervolemia, acute left ventricular failure.

    At the injection site - the development of infection, thrombophlebitis.

    Special instructions:

    For more complete assimilation of dextrose, administered in large doses, simultaneously with her, insulin is prescribed at the rate of 1 unit of insulin per 4-5 g of dextrose.

    When combined with other drugs, it is necessary to visually check compatibility.

    Form release / dosage:

    Solution for infusions, 5%, 10% and 20%.

    Packaging:

    For 50, 100, 125, 200, 250, 400, 500 ml in polyethylene bottles without a cap or with a euro-welded cap or plastic cap or stopper with an infusion or cap (euro-cap).

    For 1 bottle in a hermetically sealed packet of polymer film or without a package in a pack of cardboard box together with instructions for use.

    From 1 to 96 bottles without packs in hermetically sealed bags or without packages with an equal number of instructions for use in a corrugated box (for hospitals).

    Storage conditions:

    At a temperature of 5 to 30 ° C, out of the reach of children.

    Freezing during transportation is allowed.

    Shelf life:

    2 years.

    Do not use after the expiry date printed on the package.

    Terms of leave from pharmacies:On prescription
    Registration number:P N003903 / 01
    Date of registration:24.11.2009 / 19.08.2014
    Expiration Date:Unlimited
    The owner of the registration certificate:EAST-PHARM, LLCEAST-PHARM, LLC
    Manufacturer: & nbsp
    Information update date: & nbsp21.04.2017
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