Active substanceDextroseDextrose
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  • Dosage form: & nbspsolution for infusions
    Composition:

    Active substance: dextrose monohydrate in terms of dextrose anhydrous - 50, 100, 200 or 400 g;

    Excipients: sodium chloride - 0.26 g, water for injection - up to 1 L, 0.1 M solution of hydrochloric acid - to a pH of 3.0-4.1.

    Description:Transparent, colorless liquid (5% or 10% solution).
    Transparent, colorless or light yellow liquid (20% or 40% solution).
    Pharmacotherapeutic group:Nutrition carbohydrate remedy
    ATX: & nbsp

    B.05.C   Irrigation solutions

    V.06.D   Other medications for nutrition

    V.04.C   Other diagnostic preparations

    Pharmacodynamics:

    Participates in various metabolic processes in the body.

    The infusion of dextrose solutions partially replenishes the water deficiency. Dextrose, entering the tissue, phosphorylated, turning into glucose-6-phosphate, which is actively included in many parts of the body's metabolism.

    5% The solution of dextrose is isotonic with blood plasma.

    Hypertensive solutions (10%, 20%, 40%) increase osmotic blood pressure, increase diuresis.

    Theoretical osmolarity of 10% dextrose - 555 mOsm / l, 20% - 1110 mOsm / l.

    Pharmacokinetics:

    It is absorbed completely by the body, the kidneys are not excreted (the appearance in the urine is a pathological sign).

    Indications:

    Isotonic solution of dextrose (5%) used to restore the volume of fluid in the cell and general dehydration, with extracellular hyperhydration, a also as a component of blood substitute and anti-shock fluids.

    Hypertonic solutions of dextrose (10%, 20%, 40%) apply for hypoglycemia and liver diseases (hepatitis, dystrophy and atrophy of the liver, including liver failure), infectious diseases, toxic infections, intoxications (poisoning with drugs, cyanides, carbon monoxide, aniline, phosgene, etc.), hemorrhagic diathesis; cardiac decompensation, insufficient diuresis, edema (40%), collapse, shock, as well as partial or complete parenteral nutrition.

    As a component of various blood-substituting and anti-shock fluids; for the preparation of solutions of drugs for intravenous administration.

    Contraindications:

    Hypersensitivity, hyperglycemia, hyperlactatemia, hyperhydration, postoperative disorders of dextrose utilization; circulatory disorders that threaten edema of the brain and lungs; cerebral edema, pulmonary edema, acute left ventricular failure, decompensated chronic heart failure, hyperosmolar coma, children's age (for solutions in excess of 20-25%).

    Carefully:

    Chronic renal failure (oligoanuria), hyponatremia, diabetes mellitus.

    Pregnancy and lactation:

    Introduction is not contraindicated.

    Dosing and Administration:

    Intravenously drip.

    5% the solution is administered at a maximum rate of up to 7 ml (150 cap / min) (400 ml / h); the maximum daily intake for adults is 2 liters.

    10% solution - up to 60 cap / min (3 ml / min); the maximum daily intake for adults is 1 liter.

    20% solution - up to 30-40 cap / min (1.5-2 ml / min); the maximum daily intake for adults is 500 ml.

    40% solution - up to 30 cap / min (1.5 ml / min); the maximum daily intake for adults is 250 ml.

    Intravenously streamwise - 10-50 ml of 5% and 10% solutions.

    In adults with a normal metabolism, the daily dose of dextrose administered should not exceed 4-6 g / kg, i.e. about 250-450 g (with a decrease in intensity metabolism of the daily dose is reduced to 200-300 g), with a daily volume of injected liquid - 30-40 ml / kg. The maximum rate of dextrose administration to adults is 0.25-0.5 g / kg / h (with a decrease in the metabolic rate, the rate of administration is reduced to 0.125-0.25 g / kg / h).

    Children apply solutions with a concentration of no higher than 20-25%; the rate of dextrose administration should not exceed 0.75 g / kg / h. Children for parenteral nutrition along with fats and amino acids on the first day, 6 g of dextrose / kg / day, followed by up to 15 g / kg / day. When calculating the dose of dextrose with the administration of 5% and 10% of dextrose solutions, the permissible volume of the injected fluid should be taken into account: for children with a body weight of 2-10 kg, 100-165 ml / kg / day, children with a body weight of 10-40 kg - 45-100 ml / kg / h.

    For more complete assimilation of dextrose, administered in large doses, concomitantly with it prescribe insulin of short action at the rate of 1 unit of insulin per 4-5 g of dextrose.

    Patients with diabetes mellitus are administered dextrose under the control of its content in blood and urine.

    Side effects:

    Hyperglycemia, fever, hypervolemia, acute left ventricular failure.

    At the injection site - the development of infection, thrombophlebitis.

    Overdose:

    Symptoms: hyperglycemia, glucosuria, hyperglycemic hyperosmolar coma, hyperhydration, disturbance of the water-electrolyte balance, intensification of liponeogenesis with increased production of carbon dioxide, which leads to a sharp increase in the minute respiratory volume, respiratory rate; fatty liver infiltration.

    Treatment: stop the introduction of dextrose, introduce short-acting insulin, symptomatic therapy.

    Interaction:

    When combined with other medicines, it is necessary to visually check compatibility (possible invisible chemical or therapeutic incompatibility).

    With the introduction of dextrose solutions, control of electrolyte balance, glucose in the blood and urine is necessary.

    Special instructions:

    For a more complete and rapid assimilation of dextrose, it is possible to inject 4-5 units of insulin of short action subcutaneously, at the rate of 1 unit of short-acting insulin for 4-5 g of dextrose.

    Effect on the ability to drive transp. cf. and fur:

    During the period of treatment, care must be taken when driving vehicles and engaging in other potentially hazardous activities requiring increased attention and speed of psychomotor reactions.

    Form release / dosage:

    Solution for infusions, 5%, 10%, 20% and 40%.

    Packaging:

    For 100 ml, 200 ml, 250 ml and 400 ml (for 5% solution); 100 ml, 200 ml, 300 ml and 400 ml (for 10% solution); 200 ml and 400 ml (for 20%, 40% solutions) in glass bottles for blood, transfusion and infusion preparations sealed with rubber stoppers and crimped with aluminum caps. A bottle with instructions for use is placed in a pack of cardboard.

    For hospitals: 35 bottles of 100 ml, 28 bottles of 200 ml and 250 ml or 15 bottles of 300 ml and 400 ml together with an equal number of instructions for use are placed in boxes of corrugated cardboard with gaskets, with baffles or with grids ("sockets") without pre-stacking.

    Storage conditions:

    At a temperature of 5 to 30 ° C.

    Keep out of the reach of children.

    If the contents are clouded, do not use the bottle.

    Non-wetting of the inner surface of bottles is not a contraindication to the use of the drug.

    Shelf life:

    2 years.

    Do not use after the expiration date.

    Terms of leave from pharmacies:On prescription
    Registration number:P N001862 / 01
    Date of registration:19.09.2008 / 08.06.2015
    Expiration Date:Unlimited
    The owner of the registration certificate:DALHIMFARM, OJSC DALHIMFARM, OJSC Russia
    Manufacturer: & nbsp
    Representation: & nbspDALHIMFARM, OJSCDALHIMFARM, OJSC
    Information update date: & nbsp21.04.2017
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