Active substanceDextroseDextrose
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  • Dosage form: & nbspsolution for intravenous administration
    Composition:

    Active substance: dextrose monohydrate (in terms of 100% substance) - 400 mg;

    Excipients: 0.1 M solution of hydrochloric acid - to a pH of 3.0-4.0, sodium chloride - 0.260 mg, water for injection - up to 1.0 ml.

    Description:Transparent, colorless or slightly colored liquid.
    Pharmacotherapeutic group:Nutrition carbohydrate remedy
    ATX: & nbsp

    B.05.C   Irrigation solutions

    V.06.D   Other medications for nutrition

    V.04.C   Other diagnostic preparations

    Pharmacodynamics:

    Participates in various metabolic processes in the body, enhances oxidation-reduction processes in the body, improves the antitoxic function of the liver.

    The infusion of dextrose solutions partially replenishes the water deficiency. Dextrose, entering the tissue, phosphorylated, turning into glucose-6-phosphate, which is actively included in many parts of the body's metabolism.

    5% dextrose solution has detoxification, metabolic action, is a source of valuable easily assimilated nutrient. With the metabolism of dextrose in tissues, a significant amount of energy necessary for the vital activity of the body is released.

    Hypertensive solutions (10%, 20%, 40%) increase osmotic blood pressure, improve metabolism; increase myocardial contractility; improve the antitoxic function of the liver, dilate blood vessels, increase diuresis.

    Pharmacokinetics:

    It is absorbed completely by the body, the kidneys are not excreted (the appearance in the urine is a pathological sign).

    Indications:

    Hypoglycemia, insufficiency of carbohydrate nutrition, toxicoinfection, intoxications in liver diseases (hepatitis, dystrophy and atrophy of the liver, including hepatic insufficiency), hemorrhagic diathesis; dehydration (vomiting, diarrhea, postoperative period); intoxication; collapse, shock.

    As a component of various blood-substituting and anti-shock fluids; for the preparation of solutions of drugs for intravenous administration.

    Contraindications:Hypersensitivity, hyperglycemia, hyperlactacidemia, hyperhydration, postoperative disorders of glucose utilization; circulatory disorders that threaten edema of the brain and lungs; edema of the brain, pulmonary edema, acute left ventricular failure, hyperosmolar coma.
    Carefully:

    Decompensated chronic heart failure (CHF), chronic renal failure (CRF) (oliguria, anuria), hyponatremia, diabetes mellitus, pregnancy and lactation.

    Dosing and Administration:

    Intravenous drip, 5% solution is administered at a maximum rate of up to 7 ml (150 cap / min) (400 ml / h); the maximum daily intake for adults is 2 liters.

    10% solution - up to 60 cap / min (3 ml / min); the maximum daily intake for adults is 1 liter.

    20% solution - up to 30-40 cap / min 1,5-2 ml / min; the maximum daily intake for adults is 500 ml.

    40% solution - up to 30 cap / min (1.5 ml / min); the maximum daily intake for adults is 250 ml.

    Intravenously streamwise - 10-50 ml of 5% and 10% solutions.

    In adults with a normal metabolism, the daily dose of dextrose administered should not exceed 4-6 g / kg, i.e. about 250-450 g (with a decrease in the metabolic rate, the daily dose is reduced to 200-300 g), while the daily volume of the injected liquid is 30-40 ml / kg.

    Children for parenteral nutrition, along with fats and amino acids, 6 g of dextrose / kg / day are administered on the first day, followed by up to 15 g / kg / day. When calculating the dose of dextrose with the administration of 5% and 10% solutions of dextrose, you must take into account the permissible volume of the injected fluid: for children with a body weight of 2-10 kg - 100-165 ml / kg / day, children with a body weight of 10-40 kg - 45 -100 ml / kg / day.

    Rate of administration: at the normal state of metabolism, the maximum rate of dextrose administration to adults is 0.25-0.5 g / kg / h; with a decrease in the intensity of the metabolism, the rate of administration is reduced to 0.125-0.25 g / kg / h.In children, the rate of dextrose administration should not exceed 0.5 g / kg / h; which is 5 ml of solution - about 10 ml / min or 200 cap / min (20 cap = 1 ml).

    For more complete assimilation of dextrose, administered in large doses, simultaneously with her, insulin is prescribed at the rate of 1 unit of insulin per 4-5 g of dextrose.

    Diabetic patients with dextrose are administered under the control of its content in the blood and urine.

    Side effects:

    Hypervolaemia, acute left ventricular failure.

    At the injection site - the development of infection, thrombophlebitis.

    Overdose:

    Symptoms: hyperglycemia, glucosuria, hyperglycemic hyperosmolar coma, hyperhydration, disturbance of water-electrolyte balance.

    Treatment: to stop the introduction of glucose, to introduce insulin, symptomatic therapy.

    Interaction:

    When combined with other drugs, it is necessary to visually check compatibility.

    Special instructions:

    For more complete and rapid assimilation of dextrose, it is possible to administer 4-5 units of insulin subcutaneously, at the rate of 1 unit of insulin per 4-5 g of dextrose.

    Form release / dosage:

    Solution for intravenous administration, 400 mg / ml.

    Packaging:

    For 10 ml of the drug into neutral glass ampoules.

    For 5, 10, 30, 50 or 100 ampoules, together with the instruction for medical use of the drug and the ampoule scarifier, is placed in a cardboard box.

    For 5 or 10 ampoules, together with the instruction for medical use of the drug and the ampoule scarifier, is placed in a cardboard box with cardboard partitions, or 5 or 10 ampoules are placed in a contour mesh box made of cardboard or a polyvinylchloride film.

    1, 2, 3, 4, 5, 6, 10, 15, 20 or 30 contour mesh packages together with instructions for the medical use of the preparation and the ampoule ampoule are placed in a pack of cardboard for consumer packaging brand chromium or chrome-ersatz.

    At 10, 15, 20, 30, 40, 50, 60 or 100 contour cell packs with 5-10 instructions for medical use of the drug and 5-10 ampoule scalers are placed in a box of corrugated cardboard [for hospitals].

    When using ampoules with a notch or a fracture ring, the scarifier is not inserted.

    Storage conditions:

    In the dark place at a temperature of no higher than 30 ° C.

    Keep out of the reach of children.

    Shelf life:

    5 years.

    Do not use after the expiration date printed on the package.

    Terms of leave from pharmacies:On prescription
    Registration number:LSR-007581/08
    Date of registration:19.09.2008 / 21.01.2014
    Expiration Date:Unlimited
    The owner of the registration certificate:ESKOM NPK, OAO ESKOM NPK, OAO Russia
    Manufacturer: & nbsp
    Representation: & nbspESKOM NPK, OAOESKOM NPK, OAO
    Information update date: & nbsp22.04.2017
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