Active substanceDextroseDextrose
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  • Dosage form: & nbspsolution for intravenous administration
    Composition:

    1 ml of the solution contains:

    as an active substance: glucose in terms of anhydrous 50, 100, 250 or 400 mg:

    Excipients: solution of hydrochloric acid 0.1 M, sodium chloride, water for injection.

    Description:

    Drug solutions concentration of 50 mg / ml and 100 mg / ml: clear, colorless liquid.

    Concentration solutions of 250 mg / ml and 400 mg / ml: a clear, colorless or light yellow liquid.

    Pharmacotherapeutic group:Nutrition carbohydrate remedy
    ATX: & nbsp

    B.05.C   Irrigation solutions

    V.06.D   Other medications for nutrition

    V.04.C   Other diagnostic preparations

    Pharmacodynamics:

    Participates in various metabolic processes in the body, enhances oxidation-reduction processes in the body, improves the antitoxic function of the liver.

    The infusion of glucose solutions partially replenishes the water deficiency. Glucose entering the tissues is phosphorylated, turning into glucose-6-phosphate, which is actively included in many parts of the body's metabolism.

    5% glucose solution has detoxification, metabolic action, is a source of valuable easily assimilated nutrient. With the metabolism of glucose in tissues, a significant amount of energy necessary for the life of the organism is released.

    Hypertensive solutions (10%, 20%, 40%) increase osmotic blood pressure, improve metabolism; increase myocardial contractility; improve the antitoxic function of the liver, dilate blood vessels, increase diuresis.

    Theoretical osmolarity 10% glucose - 555 mOsm / l, 20% - 1110 mOsm / l.

    Pharmacokinetics:It is absorbed completely by the body, the kidneys are not excreted (the appearance in the urine is a pathological sign).
    Indications:

    Hypoglycemia, insufficiency of carbohydrate nutrition, toxicinfection, intoxications in liver diseases (hepatitis, dystrophy and atrophy of the liver, including liver failure), hemorrhagic diathesis; dehydration (vomiting, diarrhea, postoperative period); intoxication; collapse; shock.

    As a component of various blood-substituting and anti-shock fluids; for the preparation of solutions of drugs for intravenous administration.

    Contraindications:

    Hypersensitivity, hyperglycemia, diabetes mellitus, hyperlactacidemia, hyperhydration, postoperative disorders of glucose utilization; circulatory disorders that threaten edema of the brain and lungs; edema of the brain, pulmonary edema, acute left ventricular failure, hyperosmolar coma.

    Carefully:

    Decompensated chronic heart failure, chronic renal failure (oligo, anuria), hyponatremia.

    Dosing and Administration:

    Intravenously - 10-50 ml of 5% and 10% solutions for administration.

    In adults with a normal metabolism, the daily dose of glucose administered should not exceed 4-6 g / kg, i.e. about 250-450 g (with a decrease in the metabolic rate, the daily dose is reduced to 200-300 g), while the daily volume of the injected liquid is 30-40 ml / kg.

    Children for parenteral nutrition, along with fats and amino acids, on the first day, 6 g glucose / kg / day, followed by up to 15 g / kg / day. When calculating the dose of glucose with the introduction of 5% and 10% glucose solutions, one should take into account the permissible volume of the injected liquid: for children with a body weight of 2-10 kg - 100-165 ml / kg / day, children with a body weight of 10-40 kg - 45-100 ml / kg / day.

    For more complete assimilation of glucose, administered in large doses, simultaneously with her, insulin is prescribed at the rate of 1 unit of insulin per 4-5 g of glucose.

    Diabetes patients with glucose are administered under the control of its content in the blood and urine.

    Side effects:Hyperglycemia, fever, hypervolemia, acute left ventricular failure.
    At the injection site - the development of infection, thrombophlebitis.
    Overdose:

    Symptoms: hyperglycemia, glucosuria, hyperglycemic hyperosmolar coma, hyperhydration, disturbance of water-electrolyte balance.

    Treatment: to stop the introduction of glucose, to introduce insulin, symptomatic therapy.

    Special instructions:

    For more complete and rapid assimilation of glucose, it is possible to inject 4-5 units of insulin subcutaneously, at the rate of 1 unit of insulin per 4-5 g of glucose.

    When combined with other medicines, it is necessary to visually check compatibility (possible invisible chemical or therapeutic incompatibility).

    Form release / dosage:

    Solution for intravenous administration, 50 mg / ml, 100 mg / ml, 250 mg / ml and 400 mg / ml.

    Packaging:

    By 5 ml or 10 ml into neutral glass ampoules of grade НС-1 or НС-3.

    For 10 ampoules, together with the instructions for use and a knife for opening ampoules or a scarifier ampoule are placed in a cardboard box.

    When using ampoules with incisions, rings and break points, a scarifier ampoule or a knife for opening ampoules is allowed not to be put.

    Storage conditions:

    At a temperature of 5 to 30 ° C.

    Keep out of the reach of children.

    Freezing the drug, provided that the ampoules remain sealed, is not a contraindication to its use.

    Shelf life:

    5 years.

    After expiration date the drug should not be used.

    Terms of leave from pharmacies:On prescription
    Registration number:P N001862 / 02
    Date of registration:04.05.2008
    Expiration Date:Unlimited
    The owner of the registration certificate:DALHIMFARM, OJSC DALHIMFARM, OJSC Russia
    Manufacturer: & nbsp
    Representation: & nbspDALHIMFARM, OJSCDALHIMFARM, OJSC
    Information update date: & nbsp21.04.2017
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