Active substanceDextroseDextrose
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  • Dosage form: & nbspsolution for infusions
    Composition:

    Dextrose (glucose) monohydrate in terms of dextrose 50.0 g, sodium chloride 0.26 g, hydrochloric acid 0.1 M to pH 3,0-4,1, water for injection up to 1 liter.

    Theoretical osmolarity is 286 mOsm / l.

    Description:A clear, colorless liquid.
    Pharmacotherapeutic group:Nutrition carbohydrate remedy
    ATX: & nbsp

    B.05.C   Irrigation solutions

    V.06.D   Other medications for nutrition

    V.04.C   Other diagnostic preparations

    Pharmacodynamics:

    Glucose increases oxidation-reduction processes in the body, improves the antitoxic function of the liver, covers part of the energy expenditure of the body.

    The infusion of glucose solutions quickly replenishes the water deficiency. Glucose entering the tissues is phosphorylated, turning into glucose-6-phosphate, which is actively included in many parts of the body's metabolism.

    Isotonic 5% the glucose solution has a detoxification and metabolic action, restores the volume of circulating blood, is a source of easily digestible nutrient. With the metabolism of glucose in tissues, a significant amount of energy necessary for the life of the organism is released.

    Pharmacokinetics:

    It is absorbed completely by the body, the kidneys are not excreted (the appearance in the urine is a pathological sign).

    Indications:

    5% glucose solution: hypoglycemia; insufficiency of carbohydrate power supply; rapid replenishment of fluid volume in cellular, extracellular and general dehydration; component of blood and anti-shock fluids.

    For the preparation of drugs for intravenous administration.

    Contraindications:

    Hypersensitivity, hyperglycemia, hyperhydration, hyperosmolar coma, hyperlactatemia, postoperative glucose utilization disorders, circulatory disorders threatening cerebral edema and pulmonary edema, cerebral edema, pulmonary edema, acute left ventricular failure.

    Carefully:

    Decompensated chronic heart failure, chronic renal failure (oligo, anuria), hyponatremia, diabetes mellitus.

    Dosing and Administration:

    5% glucose solution is administered subcutaneously (up to 500 ml), intravenously drip at a rate of 150 drops / min, a maximum daily dose of 2000 ml, as well as in the rectum in enemas, drip in 300-500 ml.

    In adults with a normal metabolism, the daily dose of glucose administered should not exceed 4-6 g / kg / day, i.e. about 250-450 g / day (with a decrease in the metabolic rate the daily dose is reduced to 200-300 g), while the volume of the injected liquid is 30-40 ml / kg / day.

    Children for parenteral nutrition, along with fats and amino acids, on the first day, 6 g of glucose / kg / day, followed by up to 15 g / kg / day. When calculating the dose of glucose when 5% solution should take into account the permissible volume of the injected fluid: for children with a mass of 2-10 kg - 100-165 ml / kg / day, children with a mass of 10-40 kg - 45-100 ml / kg / day.

    Side effects:

    Hyperglycemia, fever, hypervolemia, acute left ventricular failure, at the injection site - mild pain, development of infection, sometimes thrombophlebitis.

    With repeated administration of the solution, violations of the functional state of the liver and depletion of the insulin apparatus of the pancreas are possible.

    Overdose:

    In case of an overdose, the drug should be withdrawn and symptomatic therapy should be performed. With a strong increase in sugar in the blood to carry out insulin therapy. With hyperhydration, carry out osmotherapy.

    Interaction:

    Possible invisible chemical or therapeutic incompatibility.

    When adding other drugs to the solution, it is necessary to visually check compatibility.

    Special instructions:

    A glucose solution can not be used in conjunction with blood, canned ACD.

    When using a medicinal product, control of the water-electrolyte balance is necessary. Follow the electrolyte balance! To increase osmolarity, 5% glucose solution can be combined with 0.9% sodium chloride solution.

    It is necessary to monitor the concentration of glucose in the blood. For a more complete and rapid assimilation of dextrose, it is possible to inject 4-5 units of insulin of short action subcutaneously, at the rate of 1 unit of short-acting insulin for 4-5 g of dextrose.

    For the preparation in a polymer container, freezing of the solution is possible provided the container is hermetically sealed. Check the integrity of the container before use.

    Form release / dosage:

    Solution for infusions, 5%.

    Packaging:

    For 100, 200, 400 ml in bottles of glass. 1 bottle with instructions for medical use in a pack of cardboard. 15 bottles with a capacity of 450 ml or 15, 28 bottles with a capacity of 250 ml or 36 bottles with a capacity of 100 ml along with instructions for medical use in an amount corresponding to the number of bottles in a box of corrugated (for hospitals).

    By 100, 200, 250, 300, 400, 500, 1000, 2000, 3000, 5000 ml into the polymeric containers. 44 polymer containers with a volume of 100 ml,32 polymeric containers in volume of 200 ml, 28 polymeric containers in volume of 250 ml, 20 polymeric containers in volume of 300 ml, 16 polymeric containers in volume of 400 ml, 12 polymeric containers 500 ml containers, 6 1000 ml plastic containers, 4 2000 ml polymer containers, 2 3000 ml polymer containers, 1 5000 ml polymer container in polyethylene film bags or without bags, along with a guide to the use of polymer containers with an infusion solution and instructions on medical application in an amount corresponding to the number of containers placed in a box of cardboard for consumer packaging or in a box of corrugated cardboard.

    Storage conditions:

    Store in a dark place at a temperature of 5 to 25 ° C.

    Non-wetting of the inner surface of bottles is not a contraindication to the use of the drug.

    In the case of discolouration or the appearance of a suspension, the solution is not suitable for use.

    For polymeric containers, freezing during transport is allowed.

    Shelf life:

    3 years.

    Do not use after the expiration date.

    Terms of leave from pharmacies:On prescription
    Registration number:LSR-001928/08
    Date of registration:18.03.2008 / 29.08.2014
    Expiration Date:Unlimited
    The owner of the registration certificate:MOSFARM, LLCMOSFARM, LLC
    Manufacturer: & nbsp
    Representation: & nbspMOSFARM, LLCMOSFARM, LLC
    Information update date: & nbsp21.04.2017
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