Active substanceDextroseDextrose
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  • Dosage form: & nbspsolution for intravenous administration
    Composition:

    1 ml of the preparation contains:

    Active substance:

    Dextrose (in terms of dry matter)

    400 mg

    Excipients:

    A solution of hydrochloric acid 0.1 M

    to pH 3.0-4.0

    Sodium chloride

    0.26 mg

    Water for injections

    up to 1 ml

    Description:

    Transparent, colorless or slightly yellowish liquid.

    Pharmacotherapeutic group:Nutrition carbohydrate remedy
    ATX: & nbsp

    B.05.C   Irrigation solutions

    V.06.D   Other medications for nutrition

    V.04.C   Other diagnostic preparations

    Pharmacodynamics:It participates in oxidation-reduction processes in the body, improves the antitoxic function of the liver, strengthens the contractile activity of the heart muscle, covers part of the energy expenditure, which, with a number of pathological conditions, is due to body reserves. Entering the tissue, phosphorylated, turning into glucose-6-phosphate, which is actively included in many parts of the metabolism in the body. 40% glucose solution, is hypertonic. The drug increases osmotic blood pressure, dilates blood vessels, increases diuresis.
    Pharmacokinetics:

    It is absorbed completely by the body, the kidneys are not excreted (the appearance in the urine is a pathological sign).

    Indications:

    Hypoglycemia, insufficiency of carbohydrate nutrition, toxicinfection, intoxications in liver diseases (hepatitis, dystrophy and atrophy of the liver, incl.hepatic insufficiency), hemorrhagic diathesis; dehydration (vomiting, diarrhea, postoperative period); intoxication; collapse; shock. As a component of various blood-substituting and anti-shock fluids; for the preparation of solutions of drugs for intravenous administration.

    Contraindications:

    Hypersensitivity, hyperglycemia, hyperlactacidemia, hyperhydration, postoperative disorders of glucose utilization; circulatory disorders that threaten edema of the brain and lungs; edema of the brain, pulmonary edema, acute left ventricular failure, hyperosmolar coma.

    Carefully:

    Diabetes mellitus, uncompensated heart failure, chronic renal failure (oligo-, anuria), hyponatremia.

    Pregnancy and lactation:
    Dosing and Administration:

    Intravenously drip - up to 30 cap / min (1.5 ml / min), maximum. the daily dose for adults is 250 ml.

    In adults with normal metabolism, the daily dose of dextrose administered should not exceed 4-6 g / kg, i.e. about 250-450 g (with a decrease in the metabolic rate, the daily dose is reduced to 200-300 g), while the daily volume of the injected liquid is 30-40 ml / kg.

    Children for parenteral nutrition, along with fats and amino acids, on the first day, 6 grams of dextrose / kg / day, followed by up to 15 g / kg / day.

    Rate of administration: with a normal metabolic state, the maximum rate of dextrose administration to adults is 0.25-0.5 g / kg / h (with a decrease in metabolic rate, the rate of administration is reduced to 0.125-0.25 g / kg / h). In children, the rate of dextrose administration should not exceed 0.5 g / kg / h.

    For more complete assimilation of dextrose, administered in large doses, simultaneously with her, insulin is prescribed at the rate of 1 unit of insulin per 4-5 g of dextrose. Diabetic patients with dextrose are administered under the control of its content in the blood and urine.

    Side effects:Infringement of the ion balance, hyperglycemia, fever, hypervolemia, acute left ventricular failure. At the injection site - the development of infection, thrombophlebitis.
    Overdose:

    Symptoms: hyperglycemia, glucosuria, hyperglycemic hyperosmolar coma, hyperhydration, disturbance of water-electrolyte balance.

    Treatment: stop the introduction of glucose, introduce insulin, symptomatic therapy.

    Interaction:

    When combined with other drugs, it is necessary to visually controlcompatibility (possible invisible pharmaceutical or pharmacodynamic incompatibility).

    Special instructions:

    For more complete assimilation of dextrose, administered in large doses, simultaneously with her, insulin is prescribed at the rate of 1 unit of insulin per 4-5 g of dextrose.

    When combined with other drugs, it is necessary to visually check compatibility.

    Effect on the ability to drive transp. cf. and fur:

    No data available.

    Form release / dosage:Solution for intravenous administration, 400 mg / ml.
    Packaging:

    In ampoules of 5 ml or 10 ml.

    For 10 ampoules in a pack or box of cardboard with instructions for use, a ampoule or ampoule knife with a knife. For 5 or 10 ampoules in a contour cell package. For 1 or 2 contour packs together with the instructions for use, a knife (scarifier) ​​ampoule in a pack of cardboard.

    When packing ampoules with a vestigial having a ring or dot of the opening, the opener (scarifier) ​​is not inserted into the ampoule.

    Storage conditions:

    At a temperature of 5 to 30 ° C.

    Keep out of the reach of children.

    Shelf life:

    6 years.

    Do not use after the expiration date printed on the package.

    Terms of leave from pharmacies:On prescription
    Registration number:P N000997 / 02
    Date of registration:11.09.2008 / 21.10.2014
    Expiration Date:Unlimited
    The owner of the registration certificate:MICROGEN FGUP Scientific and Production Association MICROGEN FGUP Scientific and Production Association Russia
    Manufacturer: & nbsp
    Representation: & nbspMICROGEN FGUP Scientific and Production Association MICROGEN FGUP Scientific and Production Association Russia
    Information update date: & nbsp03.05.2017
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