Active substanceDextroseDextrose
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  • Dosage form: & nbspsolution for infusions
    Composition:

    Active substances:

    Dextrose monohydrate in terms of dextrose anhydrous

    50 grams

    Excipients:

    Sodium chloride

    0.26 g

    A solution of hydrochloric acid 0.1 M

    to pH 3.0-4.1

    Water for injections

    up to 1 liter

    Description:Colorless, clear liquid.
    Pharmacotherapeutic group:Nutrition carbohydrate remedy
    ATX: & nbsp

    B.05.C   Irrigation solutions

    V.06.D   Other medications for nutrition

    V.04.C   Other diagnostic preparations

    Pharmacodynamics:

    Glucose increases oxidation-reduction processes in the body, improves the antitoxic function of the liver, covers part of the energy expenditure of the body, as it is a source of easily assimilated carbohydrates.

    5% the solution is isotonic. With the metabolism of glucose in tissues, a significant amount of energy is released, which is necessary for the vital functions of the organism.

    The solution is quickly removed from the vascular system and only temporarily increases the volume of fluid circulating in the vessels.

    Pharmacokinetics:

    It is absorbed completely by the body, the kidneys are not excreted (the appearance in the urine is a pathological sign).

    Indications:

    5% glucose solution is used to quickly fill the volume of fluid in the cell, extracellular and general dehydration, as well as a component of blood substitution and anti-shock liquids.

    Contraindications:

    Hypersensitivity, hyperglycemia, hyperlactacidemia, hyperhydration, postoperative disorders of glucose utilization; circulatory disorders that threaten edema of the brain and lungs; edema of the brain, pulmonary edema, acute left ventricular failure, hyperosmolar coma.

    Carefully:

    Decompensated CHF, CRF (oligo-, anuria), hyponatremia, diabetes mellitus.

    Dosing and Administration:

    The solution is administered intravenously at a maximum rate of up to 7 ml (150 cap / min), (400 ml / h); the maximum daily intake for adults is 2 liters.

    Intravenously struino - 10-50 ml.

    In adults with a normal metabolism, the daily dose of glucose administered should not exceed 4-6 g / kg, i.e. about 250-450 g (with a decrease in the metabolic rate, the daily dose is reduced to 200-300 g), while the daily volume of the injected liquid is 30-40 ml / kg.

    Children for parenteral nutrition along with fats and amino acids on the first day, 6 g glucose / kg / day, followed by 15 g / kg / day. When calculating the dose, it is necessary to take into account the permissible volume of the injected fluid: for children with a body weight of 2-10 kg - 100-165 ml / kg / day, children with a body weight of 10-40 kg - 45-100 ml / kg / day.

    Rate of administration: at the normal state of metabolism, the maximum rate of glucose administration to adults is 0.25-0.5 g / kg / h (with a decrease in the intensity of the metabolism, the rate of administration is reduced to 0.125-0.25 g / kg / h). In children, the rate of glucose administration should not exceed 0.5 g / kg / h, which is about 10 ml / min or 200 cap / min (20 cap = 1 ml).

    For more complete and rapid assimilation of glucose, it is possible to inject insulin of short action subcutaneously at the rate of 1 unit of insulin per 4-5 g of glucose.

    Follow the electrolyte balance!

    Diabetes patients with glucose are administered under the control of its content in the blood and urine.

    Side effects:

    Hypervolaemia, acute left ventricular failure; at excess of speed of introduction - an osmotic diuresis with loss of water, electrolytes and development of a hyperosmolar coma.

    At the injection site - the development of infection, thrombophlebitis.

    Overdose:

    Symptoms: hyperglycaemia, glucosuria, hyperglycemic hyperosmolar coma, hyperhydration, disturbance of the electrolyte introduction and electrolyte balance.

    Treatment: to stop the introduction of glucose, to introduce insulin, symptomatic therapy.

    Interaction:

    When combined with other medicines, it is necessary to visually check compatibility (possibleinvisible pharmaceutical or pharmacodynamic incompatibility).

    Form release / dosage:

    Solution for infusions, 5%.

    Packaging:

    400 ml in bottles of glass for blood, transfusion and infusion preparations with a capacity of 450 ml, corked with rubber stoppers, crimped with aluminum caps. Each label is labeled with paper. The bottle together with the instruction for use is placed in a pack of cardboard box.

    Or 15 bottles with 10 instructions for use are packed in boxes of corrugated cardboard (for hospitals).
    Storage conditions:

    At a temperature of 5 to 30 ° C.

    Keep out of the reach of children.

    Shelf life:

    2 years.

    Do not use after the date shown on the package.

    Terms of leave from pharmacies:On prescription
    Registration number:P N002772 / 01
    Date of registration:31.08.2010
    Expiration Date:Unlimited
    The owner of the registration certificate:SAMSON-MED, LLC SAMSON-MED, LLC Russia
    Manufacturer: & nbsp
    Information update date: & nbsp21.04.2017
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