According to the World Health Organization (WHO) adverse reactions are classified according to their frequency of development as follows: very often (>1/10), often (>1/100, <1/10), infrequently (>1/1000, <1/100), rarely (>1/10000, <1/1000) and very rarely (<1/10000); frequency is unknown - according to available data, it was not possible to establish the frequency of occurrence.
From the gastrointestinal tract:
often: nausea, vomiting, diarrhea, dyspepsia, abdominal pain, bloating, decreased appetite; rarely: gastritis, vomiting with an admixture of blood, gastrointestinal bleeding, melena, stomach or bowel ulcers, possibly with complications (bleeding, perforation), frequent stools with a trace of blood, proctitis;
rarely: esophageal motility disorder, nonspecific hemorrhagic colitis, exacerbation of ulcerative colitis or Crohn's disease, constipation, stomatitis, glossitis, pancreatitis, exacerbation of hemorrhoids, adhesions intestines.
From the nervous system:
often: headache, dizziness;
rarely: drowsiness;
rarely: memory impairment, convulsions, anxiety, tremor, aseptic meningitis (more often patients with systemic red lupus and other systemic connective diseases tissue), cerebrovascular violations, disorientation, depression, insomnia, nightmares dreams, irritability, weakness sensitivity (including
paresthesia).
From the sense organs:
often: vertigo;
rarely: tinnitus, violation hearing, blurred vision, diplopia, a violation of taste sensations.
From the urinary system:
very rarely: acute renal insufficiency, hematuria, proteinuria, nephrotic syndrome, interstitial nephritis, papillary necrosis.
From the organs of hematopoiesis and lymphatic system:
rarely: anemia (including hemolytic and aplastic anemia), leukopenia, thrombocytopenia (thrombocytopenic purpura), agranulocytosis.
From the immune system:
rarely: anaphylactic reactions (including hypotension and shock);
rarely: angioedema (including Quincke's edema).
From the respiratory system:
rarely: cough, bronchospasm, laryngeal edema;
rarely: pneumonitis.
From the cardiovascular system:
infrequently: myocardial infarction, chronic heart failure;
rarely: increased blood pressure, vasculitis, palpitations, extrasystole, pain in the chest cell.
From the skin:
often: skin rash;
rarely: hives;
rarely: bullous rash, toxic dermatitis, eczema, polymorphic erythema, toxic
epidermal necrolysis (syndrome Lyell, Stevens-Johnson), photosensitization.
From the side of the liver and bile ducts:
often: increased activity "hepatic" transaminases
rarely: jaundice, liver damage;
rarely: hepatitis (possibly fulminant course), necrosis liver, cirrhosis, hepatorenal
syndrome, hepatic failure.
Other:
rarely: edema.
General disorders and disorders in place of administration:
often: irritation in place introduction.