To reduce the risk of developing adverse events, use a minimally effective dose with a short course.
Gastrointestinal tract:
more often 1% - abdominal pain, sensation of bloating, diarrhea, digestive disorders, nausea, constipation, flatulence, increased level of "liver" enzymes, peptic ulcer with possible complications (bleeding, perforation), gastrointestinal bleeding;
less often% vomiting, jaundice, melena, the appearance of blood in the stool, esophagus damage, aphthous stomatitis, dry mouth and mucous membranes, hepatitis (possibly fulminant), liver necrosis, cirrhosis, hepatorenal syndrome, appetite change, pancreatitis, cholecystopancreatitis, colitis.
Nervous system:
more often 1% - headache, dizziness;
less than 1% - sleep disturbance, drowsiness, depression, irritability, aseptic
meningitis (usually in patients with systemic lupus erythematosus and other systemic
connective tissue diseases), convulsions, weakness, disorientation, nightmares
dreams, a sense of fear.
Sense organs:
more often 1% - noise in the ears;
less than 1% - blurred vision, diplopia, a taste disorder, reversible or irreversible hearing loss, scotoma.
Skin covers.
more often 1% - skin itch, skin rash;
less than 1% - alopecia, urticaria, eczema, toxic dermatitis, multiforme exudative erythema, incl. Stevens-Johnson syndrome, toxic epidermal necrolysis (Lyell's syndrome), increased photosensitivity,
small-point hemorrhages.
Genitourinary system:
more often 1% - fluid retention;
less than 1% - nephrotic syndrome, proteinuria, oliguria, hematuria, interstitial nephritis, papillary necrosis, acute renal failure, azotemia.
Hematopoiesis and the immune system:
less than 1% - anemia (including hemolytic and aplastic anemia), leukopenia, thrombocytopenia, eosinophilia, agranulocytosis, thrombocytopenic purpura, worsening of the course of infectious processes (development of necrotizing fasciitis, pneumonia).
Respiratory system:
less than 1% - cough, bronchospasm, laryngeal edema, pneumonitis.
The cardiovascular system:
less than 1% - increased blood pressure; congestive heart failure, extrasystole, chest pain.
Allergic reactions:
less often% - anaphylactoid reactions, anaphylactic shock (usually develops rapidly), swelling of the lips and tongue, allergic vasculitis.
Local reactions with intramuscular injection:
burning, infiltration, aseptic necrosis, necrosis of adipose tissue.