Frequent adverse reactions - develop in more than 1 case for 100 appointments, infrequent - the incidence of less than 1 case per 100, but more than 1 case per 1000 prescriptions, and rare - the incidence of less than 1 case per 1000 prescriptions, but more than 1 per 10,000, very rare - frequency is less than 1 per 10000.
On the part of the blood and lymphatic system
very rare: thrombocytopenia, leukopenia, anemia (including hemolytic and aplastic anemia), agranulocytosis.
From the immune system
- rare, hypersensitivity, anaphylactic and anaphylactoid reactions (including arterial hypotension and shock);
- very rare: angioedema (including swelling of the face).
- Psychoemotional disorders
- very rare: loss of orientation, depression, insomnia, nightmares, irritability, psychotic disorders.
Violations of the function of the nervous system
- frequent: headache, dizziness;
- rare, drowsy;
- very rare, paresthesia, memory impairment, convulsions, anxiety, tremor, aseptic meningitis, taste disorders, cerebrovascular disorders.
From the side of the vision system
- very rare, visual disturbances (blurred vision, diplopia).
- From the side of AOP-organ
- frequent, dizziness;
- very rare: ringing in the ears, hearing impairment.
- From the side of the cardiovascular system
- very rare, heart palpitations, chest pain, heart failure, myocardial infarction, hypertension, vasculitis.
On the part of the respiratory system
- rare: bronchial asthma (including dyspnea);
- very rare: pneumonia.
From the gastrointestinal tract
- frequent: nausea, vomiting, diarrhea, indigestion, abdominal pain, flatulence, anorexia, increased levels of hepatic transaminases;
- rare: gastritis, gastrointestinal bleeding, bloody vomiting, diarrhea, melena with blood, stomach ulcers or intestines (with or without bleeding or perforation), hepatitis, jaundice;
- very rare: colitis (including blood, exacerbation of ulcerative colitis or Crohn's disease), constipation, stomatitis, glossitis, esophageal pathology, esophageal aperture structure, pancreatitis, fulminant hepatitis.
From the skin and subcutaneous tissues
- frequent: rash;
- rare: urticaria;
- very rare: a rash in the form of blisters, eczema, erythema multiforme, Stevens-Johnson syndrome, Lyell's syndrome (acute toxic epidermolysis), erythroderma (exfoliative dermatitis), hair loss. Photosensitive reactions; purpura, including allergic purpura.
From the side of the kidneys and urinary tract
very rare: acute renal failure, hematuria and proteinuria, interstitial nephritis; nephrotic syndrome; papillary necrosis.
Common violations
rare: edema.