Active substanceDiclofenacDiclofenac
Similar drugsTo uncover
  • Argett Duo
    capsules inwards 
  • Argett Rapid
    capsules
  • Voltaren®
    patch externally 
  • Voltaren®
    patch externally 
  • Voltaren®
    spray externally 
  • Voltaren®
    suppositories rect. 
    Novartis Pharma AG     Switzerland
  • Voltaren®
    pills inwards 
  • Voltaren®
    pills inwards 
    Novartis Pharma AG     Switzerland
  • Voltaren®
    solution w / m 
    Novartis Pharma AG     Switzerland
  • Voltaren®-Flotac®
    capsules inwards 
    Novartis Pharma AG     Switzerland
  • Voltaren® Acti
    pills inwards 
  • Voltaren® Ophta
    drops d / eye 
  • Voltaren Rapid
    powder inwards 
    Novartis Pharma AG     Switzerland
  • Voltaren Rapid
    pills inwards 
    Novartis Pharma AG     Switzerland
  • Voltaren® Emulgel®
    gel externally 
  • Voltaren® Emulgel®
    gel externally 
  • Diclac®
    pills inwards 
    Sandoz d.     Slovenia
  • Diclac®
    suppositories rect. 
    Sandoz d.     Slovenia
  • Diclac®
    solution w / m 
    Sandoz d.     Slovenia
  • Diclac®
    gel externally 
    Sandoz d.     Slovenia
  • Diclac® Lipogel
    gel externally 
    Sandoz d.     Slovenia
  • Diklo-F
    drops d / eye 
  • Diklovit®
    gel externally 
  • Diklovit®
    suppositories rect. 
  • Diklogen®
    pills inwards 
  • Diklogen®
    gel externally 
  • Diklogen®
    pills inwards 
  • Diklogen®
    solution w / m 
  • Diklogen®
    gel externally 
  • Diclonat® P
    solution w / m 
  • Dicloran®
    gel externally 
  • Diclofenac
    suppositories rect. 
    FARMENT FIRM, LLC     Russia
  • Diclofenac
    solution w / m 
    GROTEKS, LLC     Russia
  • Diclofenac
    drops d / eye 
    SYNTHESIS, OJSC     Russia
  • Diclofenac
    pills inwards 
    SYNTHESIS, OJSC     Russia
  • Diclofenac
    ointment externally 
  • Diclofenac
    suppositories rect. 
  • Diclofenac
    gel externally 
  • ATOLL, LLC     Russia
  • Diclofenac
    solution w / m 
    ATOLL, LLC     Russia
  • Diclofenac
    solution w / m 
    ELLARA, LTD.     Russia
  • Diclofenac
    solution w / m 
    ALVILS, LTD.     Russia
  • Diclofenac
    solution w / m 
  • Diclofenac
    gel externally 
  • Diclofenac
    pills inwards 
    BIOSINTEZ, PAO     Russia
  • Diclofenac
    ointment externally 
    ATOLL, LLC     Russia
  • Diclofenac
    solution w / m 
    DALHIMFARM, OJSC     Russia
  • Diclofenac
    ointment
    GREEN DUBRAVA, CJSC     Russia
  • Diclofenac
    suppositories
    ALTAYVITAMINS, CJSC     Russia
  • Diclofenac
    pills inwards 
  • Diclofenac
    solution w / m 
  • Diclofenac
    suppositories rect. 
    BIOSINTEZ, PAO     Russia
  • Diclofenac
    solution w / m 
  • Diclofenac
    gel externally 
  • Diclofenac
    pills inwards 
  • Diclofenac
    solution w / m 
  • Diclofenac
    suppositories rect. 
  • Diclofenac
    gel externally 
    ELFA NPC, CJSC     Russia
  • Diclofenac
    suppositories rect. 
    DALHIMFARM, OJSC     Russia
  • Diclofenac
    solution w / m 
  • Diclofenac
    ointment externally 
  • Diclofenac
    pills inwards 
    ZIO-HEALTH, JSC     Russia
  • Diclofenac
    solution w / m 
  • Diclofenac
    solution w / m 
    Hanmi Farm. Co., Ltd     The Republic of Korea
  • Diclofenac
    pills inwards 
  • Diclofenac
    pills inwards 
  • Diclofenac
    drops d / eye 
  • Diclofenac
    solution w / m 
  • Diclofenac
    pills inwards 
  • Diclofenac
    pills inwards 
  • Diclofenac
    solution
  • Diclofenac
    suppositories rect. 
    Magister KiK     Romania
  • Diclofenac
    gel externally 
    Hemofarm AD     Serbia
  • Diclofenac
    solution w / m 
    BIOSINTEZ, PAO     Russia
  • Diclofenac
    ointment externally 
    BIOSINTEZ, PAO     Russia
  • Diclofenac
    pills inwards 
    Natur Product Europe BV     Netherlands
  • Diclofenac
    suppositories rect. 
    FARMAPRIM, LLC     The Republic of Moldova
  • Diclofenac
    solutionpills inwards w / m 
  • Diclofenac
    pills inwards 
    OZONE, LLC     Russia
  • Diclofenac
    drops d / eye 
  • Diclofenac
    pills inwards 
    VALENTA PHARM, PAO     Russia
  • Diclofenac
    solution w / m 
  • Diclofenac
    gel externally 
    SYNTHESIS, OJSC     Russia
  • Diclofenac
    gel externally 
    SYNTHESIS, OJSC     Russia
  • Diclofenac
    solution w / m 
  • Diclofenac
    gel externally 
    ATOLL, LLC     Russia
  • Diclofenac
    gel externally 
  • Diclofenac Wellpharm
    solution w / m 
    VELFARM, LLC     Republic of San Marino
  • Diclofenac Grindeks
    ointment externally 
    GRINDEX, JSC     Latvia
  • Diclofenac retard
    pills inwards 
    OZONE, LLC     Russia
  • Diclofenac retard-Akrihin
    pills inwards 
    AKRIKHIN HFK, JSC     Russia
  • Diclofenac Sandoz®
    pills inwards 
    Sandoz d.     Slovenia
  • Diclofenac Sandoz®
    pills inwards 
    Sandoz d.     Slovenia
  • Diclofenac Stade®
    pills inwards 
  • Diclofenac Stade®
    pills inwards 
  • Elf Diclofenac
    solution w / m 
  • Diclofenac-Akos
    solution w / m 
    SYNTHESIS, OJSC     Russia
  • Diclofenac-Akos
    ointment externally 
    SYNTHESIS, OJSC     Russia
  • Diclofenac-Acrychin®
    gel externally 
    AKRIKHIN HFK, JSC     Russia
  • AKRIKHIN HFK, JSC     Russia
  • Diclofenac-Acrychin
    gel externally 
    AKRIKHIN HFK, JSC     Russia
  • Diclofenac-Altpharm
    suppositories rect. 
    ALTFARM, LLC     Russia
  • Diclofenac-MFF
    suppositories rect. 
  • Diclofenac-MFF
    ointment externally 
  • Diclofenac-ratopharm
    suppositories rect. 
    ratiofarm GmbH     Germany
  • Diclofenac-SOLOfarm
    drops d / eye 
    GROTEKS, LLC     Russia
  • Diclofenac-Teva
    gel externally 
  • Diclofenac-UBF
    pills inwards 
    URALBIOFARM, OJSC     Russia
  • Diclofenac-FPO
    pills inwards 
  • Diclofenac-Eskom
    solution w / m 
    ESKOM NPK, OAO     Russia
  • Diclofenaclong®
    drops d / eye 
    FIRN M, ZAO     Russia
  • Diclofenacol
    cream externally 
    Hiperion S.A.     Romania
  • Dorosan
    aerosol externally 
    Rottafarm SpA     Italy
  • Naklofen
    solution w / m 
  • Naklofen
    pills inwards 
  • Naklofen
    suppositories rect. 
  • Naklofen
    gel externally 
  • Naklofen Duo
    capsules inwards 
  • Naklofen Protect
    capsules inwards 
    KRKA-RUS, LLC     Russia
  • Naklofen SR
    pills inwards 
  • Orthophene
    gel externally 
    VERTEKS, AO     Russia
  • Orthophene
    solution w / m 
  • Orthophene
    pills inwards 
  • Orthophene
    ointment externally 
    VERTEKS, AO     Russia
  • Orthofer®
    ointment externally 
    BRYNTSALOV-A, CJSC     Russia
  • Orthofer®
    pills inwards 
    BRYNTSALOV-A, CJSC     Russia
  • Orthofer®
    solution w / m 
    BRYNTSALOV-A, CJSC     Russia
  • Penseid
    solution externally 
    NovaMedika, OOO     Russia
  • Rapten Duo
    pills inwards 
    Hemofarm AD     Serbia
  • Rapent Rapid
    pills inwards 
    Hemofarm AD     Serbia
  • Rapent Rapid
    pills inwards 
    Hemofarm AD     Serbia
  • Tabuk-Di
    pills inwards 
  • The Flector
    patch through. 
  • Dosage form: & nbspSuppositories rectal.
    Composition:
    In 1 suppository contains:

    Active substance:

    diclofenac sodium - 50 mg or 100 mg

    basis for suppositories: solid fat, type A - sufficient amount to obtain a suppository with a mass of 1.25 g or 2.0 g.
    Description:Suppositories white or white with a yellowish hue of color, torpedo-shaped.
    Pharmacotherapeutic group:Non-steroidal anti-inflammatory drug (NSAID).
    ATX: & nbsp

    S.01.B.C.03   Diclofenac

    M.01.A.B.05   Diclofenac

    Pharmacodynamics:Non-steroidal anti-inflammatory drug, a derivative of phenylacetic acid; has anti-inflammatory, analgesic and antipyretic effect. Indiscriminately inhibiting cyclooxygenase 1 and cyclooxygenase 2, disrupts the metabolism of arachidonic acid, reduces the amount of prostaglandins in the inflammatory focus. The most effective for inflammatory pain. Like all non-steroidal anti-inflammatory drugs, the drug has anti-aggregative activity.
    Pharmacokinetics:
    The maximum concentration in the blood plasma is created after 30-40 minutes and is in linear dependence on the used dose. Changes in the pharmacokinetics of diclofenac against the background of repeated administration are not noted, do not accumulate. The connection with plasma proteins is not more than 99% (most of it is associated with albumins). Penetrates into the synovial fluid. The maximum concentration in the synovial fluid is observed 2-4 hours later than in the plasma. The half-life of the synovial fluid is 3-6 hours (the concentration of the active substance in the synovial fluid 4-6 hours after the administration of the drug is higher than in the plasma, and remains higher for another 12 hours). The relationship between the concentration of the drug in the synovial fluid and the clinical efficacy of the drug has not been elucidated.

    Metabolism occurs as a result of multiple or one-time hydroxylation and conjugation with glucuronic acid. The enzyme system P450 CYP2C9 takes part in the metabolism of the drug. The pharmacological activity of metabolites is lower than that of diclofenac.

    The system clearance is 350 ml / min, the volume of distribution is 550 ml / kg. The half-life of plasma is 2 hours.65% of the administered dose is excreted as metabolites by the kidneys; less than 1% is unchanged, the rest of the dose is excreted as metabolites with bile.

    In patients with severe renal failure (creatinine clearance less than 10 ml / min), the excretion of metabolites with bile is increased, while there is no increase in their concentration in the blood.

    In patients with chronic hepatitis or compensated cirrhosis, the pharmacokinetic parameters of diclofenac do not change. Diclofenac penetrates into breast milk.
    Indications:Symptomatic treatment of diseases of the musculoskeletal system (rheumatoid arthritis, psoriatic arthritis, ankylosing spondylitis, gouty arthritis, rheumatic soft tissue damage, osteoarthritis of peripheral joints and spine, including radicular syndrome, tendovaginitis, bursitis). The drug is intended for symptomatic therapy, reducing pain and inflammation at the time of use, the progression of the disease is not affected. Pain syndrome of mild or moderate severity: neuralgia, myalgia, lumboschialgia, posttraumatic pain syndrome, accompanied by inflammation,postoperative pain, headache, migraine, algodismenorea, adnexitis, toothache.
    Contraindications:
    - The period after aortocoronary bypass surgery.

    - III trimester of pregnancy, the period of breastfeeding.

    - Uncompensated heart failure.

    - Hypersensitivity to the active substance or ancillary components.

    - Anamnestic data on an attack of bronchial obstruction, rhinitis, urticaria after taking acetylsalicylic acid or other NSAIDs (complete or incomplete acetylsalicylic acid intolerance syndrome - rhinosinusitis, urticaria, polyps of the nasal mucosa, asthma).

    - Erosive-ulcerative changes in the gastric mucosa or duodenum, active gastrointestinal bleeding.

    - Exacerbation of inflammatory bowel diseases (ulcerative colitis, Crohn's disease).

    - Cerebrovascular bleeding or other bleeding and hemostasis disorders.

    - Severe hepatic impairment or active liver disease.

    - Severe renal insufficiency (creatinine clearance less than 30 ml / min), progressive kidney disease, incl. confirmed hyperkalemia.

    - Children's age (up to 18 years for suppositories of 100 mg, up to 15 years for suppositories of 50 mg).

    - Rectal bleeding, hemorrhoids, trauma or inflammation of the rectum.
    Carefully:
    Anemia, bronchial asthma, cerebrovascular disease, coronary heart disease, congestive heart failure, arterial hypertension, peripheral arterial disease, edematous syndrome, hepatic or renal failure, dyslipidemia / hyperlipidemia, diabetes mellitus, smoking, inflammatory bowel disease, condition after extensive surgery, induced porphyria, elderly age, diverticulitis, systemic connective tissue diseases, creatinine clearance from 30 to 60 ml / min, (I-II trimester).

    A history of the development of ulcerative diseases of the gastrointestinal tract, the presence of infection Helicobacter pylori, long-term use of NSAIDs, frequent alcohol consumption, severe somatic diseases.

    Simultaneous therapy with anticoagulants (for example, warfarin), antiplatelet agents (for example, acetylsalicylic acid, clopidogrel), oral glucocorticosteroids (for example, prednisolone), selective serotonin reuptake inhibitors (eg, citalopram, fluoxetine, paroxetine, sertraline).
    Dosing and Administration:Rectally, the adults receive an initial dose of 100-150 mg / day, divided into 2-3 doses; in mild cases and with prolonged therapy - 50-100 mg / day; in addition to oral administration, the total daily dose (rectally and orally) should not exceed 150 mg. With algodismenosis (with the appearance of the first symptoms) the initial dose is 50-100 mg / day, which, if necessary, is increased for several menstrual cycles to 150 mg. A migraine attack is 100 mg at the first signs of an attack. If necessary -repeatedly 100 mg. If it is necessary to continue treatment in the following days, the daily dose should not exceed 150 mg for several administrations. In adolescents older than 15 years, only suppositories of 50 mg are used, a single dose does not exceed 1 suppository.
    Side effects:

    Often - 1-10%; sometimes 0.1-1%; rarely - 0,01-0,1%; very rarely - less than 0.001%, including individual cases.

    From the digestive system: often - epigastric pain, nausea, vomiting, diarrhea, dyspepsia, flatulence, anorexia, increased activity of aminotransferases; rarely - gastritis, proctitis, bleeding from the digestive tract (vomiting with blood, melena, diarrhea with an admixture of blood),Gastrointestinal ulcers (with or without bleeding or perforation), hepatitis, jaundice, impaired liver function; very rarely - stomatitis, glossitis, damage to the esophagus, diaphragm-like intestinal strictures, nonspecific hemorrhagic colitis, exacerbation of ulcerative colitis or Crohn's disease, constipation, pancreatitis, fulminant hepatitis, exacerbation of hemorrhoids.

    From the nervous system: often - headache, dizziness; rarely - drowsiness; very rarely - a violation of sensitivity, incl. paresthesia, memory disorders, tremors, convulsions, anxiety, cerebrovascular disorders, aseptic meningitis, disorientation, depression, insomnia, nightmares, irritability, mental disorders.

    From the sense organs: often - vertigo; very rarely - visual impairment (blurred vision, diplopia), hearing impairment, tinnitus, a violation of taste sensations.

    Co side of the urinary system: very rarely - acute renal failure, hematuria, proteinuria, interstitial nephritis, nephrotic syndrome, papillary necrosis.

    From the hematopoiesis: very rarely - thrombocytopenia, leukopenia, hemolytic and aplastic anemia, agranulocytosis.

    Allergic reactions: anaphylactic / anaphylactoid reactions, including a marked decrease in blood pressure and shock; very rarely - angioedema (including face).

    From the cardiovascular system: very rarely - palpitations, chest pain, increased blood pressure, vasculitis, heart failure, myocardial infarction.

    From the respiratory system: rarely - bronchial asthma (including dyspnea); very rarely - pneumonitis.

    From the skin: often - skin rash; rarely - hives; very rarely - bullous eruptions, eczema, incl. multiform and Stevens-Johnson syndrome, Lyell's syndrome, exfoliative dermatitis, itching, hair loss, photosensitivity, purpura, incl. allergic.

    Local reactions with rectal administration: irritation of the mucous membrane of the rectum, mucous discharge with an admixture of blood, pain during defecation, rectal bleeding.

    Overdose:
    Symptoms: dizziness, headache, hyperventilation of the lungs, blurred consciousness, in children - myoclonic cramps, nausea, vomiting, abdominal pain, bleeding from the digestive tract, impaired liver and kidney function.

    Treatment: Activated carbon, symptomatic therapy. Forced diuresis, hemodialysis are ineffective.
    Interaction:
    Increases the concentration in the plasma digoxin, methotrexate, lithium and cyclosporine.

    Reduces the effect of diuretics, against the background of potassium-sparing diuretics increases the risk of hyperkalemia; against the background of anticoagulants, thrombolytic agents (alteplase, streptokinase, urokinase) - the risk of bleeding (more often from the gastrointestinal tract). Reduces the effects of hypotensive and hypnotics.

    Increases the likelihood of side effects of other non-steroidal anti-inflammatory drugs and glucocorticosteroid agents (bleeding in the gastrointestinal tract), toxicity of methotrexate and nephrotoxicity of cyclosporine. Acetylsalicylic acid reduces the concentration of diclofenac in the blood. Simultaneous use with paracetamol increases the risk of developing nephrotoxic effects of diclofenac. Reduces the effect of hypoglycemic agents.

    Cefamandol, cefoperazone, cefotetan, valproic acid and plikamycin increase the incidence of hypoprothrombinemia.

    Cyclosporine and gold preparations increase the effect of diclofenac on the synthesis of prostaglandins in the kidneys, which increases nephrotoxicity.

    Simultaneous administration with ethanol, colchicine, corticotropin, serotonin reuptake inhibitors and St. John's wort preparations increases the risk of bleeding in the gastrointestinal tract.

    Diclofenac enhances the effect of drugs that cause photosensitivity. Drugs that block tubular secretion, increase the concentration in the plasma of diclofenac, thereby increasing its toxicity.

    Antibacterial drugs from the quinolone group - the risk of seizures. Effect on the results of laboratory tests: diclofenac may affect serum transaminase levels (if this effect is long-lasting or if complications occur, treatment should be discontinued), and may cause an increase in potassium concentration.
    Special instructions:
    Because of the important role of prostaglandins in maintaining renal blood flow, care should be taken when assigning to patients with cardiac or renal insufficiency, as well as in the treatment of elderly patients taking diuretics,which for some reason has a decrease in the volume of circulating blood (for example, after major surgery). If in such cases appoint diclofenac, recommend as a precautionary measure to monitor kidney function.

    In patients with hepatic insufficiency (chronic hepatitis, compensating cirrhosis of the liver), the kinetics and metabolism do not differ from similar processes in patients with normal liver function. When performing long-term therapy, it is necessary to monitor liver function, the picture of peripheral blood, the analysis of feces for latent blood.

    During the treatment, it is possible to reduce the speed of mental and motor reactions, so it is necessary to refrain from driving motor vehicles and practicing other potentially dangerous activities that require an increased concentration of attention and speed of psychomotor reactions.
    Form release / dosage:
    Suppositories rectal 50 mg and 100 mg.
    Packaging:
    For 5 suppositories in a contour cell box from a polyvinyl chloride film. Two contour squares with instructions for use are placed in a pack of cardboard.
    Storage conditions:
    List B.In a dry, dark place at a temperature of no higher than 15 ° C. Keep out of the reach of children.

    Shelf life:
    2 years

    Do not use after the expiration date printed on the package.
    Terms of leave from pharmacies:On prescription
    Registration number:LSR-002810/10
    Date of registration:02.04.2010
    The owner of the registration certificate:DALHIMFARM, OJSC DALHIMFARM, OJSC Russia
    Manufacturer: & nbsp
    Information update date: & nbsp17.02.2016
    Illustrated instructions
      Instructions
      Up