Criteria for assessing the incidence of adverse reactions: very often (> 1/10). often (>1/100, <1/10). infrequently (>1/1000, <1/100). rarely (>1/10000, <1/1000) and very rarely (<1/10000); the frequency is unknown - it is not possible to establish the frequency of occurrence from the available data.
Disorders from the gastrointestinal tract: often epigastric pain, nausea, vomiting, diarrhea, dyspepsia, flatulence, anorexia: rarely - gastritis, proctitis, bleeding from the gastrointestinal tract (vomiting with blood, melena, diarrhea with blood impurities), gastrointestinal ulcers or without bleeding or perforation); very rarely - stomatitis, glossitis, esophagitis. nonspecific hemorrhagic colitis, exacerbation of ulcerative colitis or Crohn's disease, the appearance of diaphragm-like strictures in the intestine, constipation, pancreatitis.
Disorders from the liver and bile ducts: often - increased activity of aminotransferases; rarely - hepatitis, jaundice, a violation of liver function; very rarely - fulminant hepatitis, liver necrosis, liver failure.
Impaired nervous system: often - headache, dizziness: rarely - drowsiness; very rarely - a violation of sensitivity, incl. paresthesia, memory disorders, tremors, convulsions, anxiety, cerebrovascular disorders, aseptic meningitis.
Disorders of the psyche: very rarely - disorientation, depression, insomnia, night "nightmares", irritability, mental disorders.
Impaired sensory organs: often - vertigo; very rarely - visual impairment (blurred vision, diplopia), hearing impairment, tinnitus, a violation of taste sensations.
Disorders from the kidneys and urinary tract: very rarely - acute renal failure, hematuria, proteinuria, interstitial nephritis, nephrotic syndrome, papillary necrosis.
Violations from the blood and lymphatic system: very rarely thrombocytopenia. leukopenia, hemolytic and aplastic anemia, agranulocytosis, eosinophilia.
Immune system disorders: anaphylactic / anaphylactoid reactions, including a marked decrease in blood pressure (BP) and shock: very rarely - angioedema (including facial).
Disorders from the cardiovascular system: very rarely - a feeling of palpitation, chest pain, increased blood pressure, vasculitis, heart failure, myocardial infarction.
Disturbances from the respiratory system, chest and mediastinal organs: rarely - exacerbation of bronchial asthma, cough, edema of the larynx: very rarely - pneumonitis.
Disturbances from the skin and subcutaneous tissues: often - skin rash; rarely - hives: very rarely - bullous eruptions, eczema, incl. multiform and Stevens-Johnson syndrome, Lyell's syndrome, exfoliative dermatitis, itching, hair loss, photosensitivity, purpura, incl. allergic.
General disorders and disorders at the site of administration: rarely - swelling.