Often (>1/10), often (>1/100, <1/10). infrequently (>1/1000? <1/100), rarely (>1/10000, <1/1000) and very rarely (<1/10000); frequency is unknown - according to available data, it was not possible to establish the frequency of occurrence.
From the digestive system: often epigastric pain, nausea, vomiting. diarrhea, dyspepsia, flatulence, anor- sia. increased activity of aminotransferase; rarely gastritis, proctitis, bleeding from the gastrointestinal tract (vomiting from the larynx, melanoma diarrhea, blood sores), gastrointestinal ulcers (with or without bleeding or perforation), hepatitis, jaundice. abnormal liver function; very rarely - stomatitis, glossitis, esophagitis, nonspecific hemorrhagic colitis, exacerbation of ulcerative colitis or Crohn's disease,constipation, pancreatitis, fulminant hepatitis.
From the nervous system: often - headache, dizziness; rarely - drowsiness; very rarely - a violation of sensitivity, incl. paresthesia, memory disorders, tremor, convulsions, anxiety, cerebrovascular disorders, aseptic meningitis (more often in patients with systemic lupus erythematosus and other systemic connective tissue diseases), disorientation, depression. insomnia, nightmares. irritability. mental disorders.
From the sense organs: often - the vertical; very rarely - visual impairment (blurred vision, diplopia), hearing impairment, tinnitus, a violation of taste sensations.
From the urinary system: very rarely - acute renal failure, hematuria, proteinuria, interstitial nephritis, nephrotic syndrome, papillary necrosis.
From the hematopoiesis: very rarely - thrombocytopenia. leukopenia, anemia (including hemolytic and aplastic), agranulocytosis.
Allergic reactions: anaphylactic / anaphylactoid reactions, including a marked decrease in blood pressure and anaphylactic shock; very rarely - angioedema (including face).
From the cardiovascular system: very rarely - palpitations, chest pain, increased blood pressure, vasculitis, heart failure, myocardial infarction.
From the respiratory system: rarely - bronchial asthma (including dyspnea); very rarely - pneumonitis.
From the skin: often - skin rash; rarely - hives; very rarely - bullous eruptions, erythema, incl. multiform and Stevens-Johnson syndrome, Lyell syndrome, exfoliative dermatitis, itching. loss of hair, photosensitivity. purpura, incl. allergic.
Other: often - irritation at the injection site; very rarely - an abscess at the injection site; rarely - swelling.
Long-term therapy with diclofenac for systemic use, especially in high doses (150 mg / day), may increase the risk of developing thrombotic lesions of arterial vessels (eg, myocardial infarction or stroke).