To reduce the risk of developing adverse events, use a minimally effective dose with a short course.
Often - 1-10%; sometimes 0.1-1%; rarely - 0,01-0.1%; very rarely - less than 0.001%, including individual cases.
From the digestive system:
- often - epigastric pain, nausea, vomiting, diarrhea, dyspepsia, flatulence, anorexia, increased activity of aminotransferases;
- rarely - gastritis, proctitis, bleeding from the gastrointestinal (vomiting krovyo, melena, diarrhea mixed with blood), ulcers of the gastrointestinal tract (with or without bleeding or perforation), hepatitis, jaundice, liver dysfunction;
- very rarely - stomatitis, glossitis, esophageal injuries, bowel diafragmopodobnye stiktury (nonspecific hemorrhagic colitis, exacerbation of ulcerative colitis or Crohn's disease), constipation, pancreatitis, fulminant hepatitis.
From the nervous system:
- often - headache, dizziness;
- rarely - drowsiness;
- very rarely - a violation of sensitivity, incl. paresthesia, memory disturbances, tremors, convulsions, anxiety, cerebrovascular disorders, aseptic meningitis, confusion, depression, insomnia, night "nightmares", irritability, personality disorders.
From the sense organs:
- often - vertigo;
- very rarely - visual impairment (blurred vision, diplopia), hearing impairment, tinnitus, a violation of taste sensations.
From the urinary system:
- very rarely - acute renal failure, hematuria, proteinuria, interstitial nephritis, nephrotic syndrome, papillary necrosis.
From the hematopoiesis:
- very rarely - thrombocytopenia, leukopenia, hemolytic and aplastic anemia, agranulocytosis.
Allergic reactions:
- anaphylactic / anaphylactoid reactions, including a marked decrease in blood pressure and shock;
- very rarely - angioedema (including face).
From the cardiovascular system:.
- very rarely - palpitations, chest pain, increased blood pressure, vasculitis, heart failure, myocardial infarction.
From the respiratory system:
- rarely - bronchial asthma (including dyspnea);
- very rarely - pneumonitis.
From the skin:
- often - skin rash;
- rarely - hives;
- very rarely - bullous eruptions, eczema, incl. multiform and Stevens-Johnson syndrome, Lyell's syndrome, exfoliative dermatitis, itching, hair loss, photosensitivity, purpura, incl. allergic.
Local reactions with intramuscular injection:
burning, infiltration, aseptic necrosis, necrosis of adipose tissue.