Classification of the incidence of side effects recommended by the World
Health Organization (WHO):
Very often (from ≥1/10)
Often (from ≥1 / 100 to <1/10)
Infrequently (from ≥1 / 1000 to <1/100)
Rarely (from ≥1 / 10000 to <1/1000)
Very rarely (from <1/10000)
Frequency is unknown (can not be estimated from available data)
Diclofenac
From the digestive system:
often: epigastric pain, nausea, vomiting, diarrhea, dyspepsia, flatulence, anorexia, increased activity of aminotransferases;
rarely: gastritis, proctitis, bleeding from the digestive tract (vomiting with blood, melena, diarrhea with a trace of blood), gastrointestinal ulcers (with or without bleeding or perforation), hepatitis, jaundice, impaired liver function;
very rarely: stomatitis, glossitis, esophagitis, nonspecific hemorrhagic colitis, exacerbation of ulcerative colitis or Crohn's disease, constipation, pancreatitis, fulminant hepatitis;
From the nervous system:
often: headache, dizziness; rarely: drowsiness;
very rarely: a violation of sensitivity (including paresthesia), memory disorders, tremors, convulsions, anxiety, cerebrovascular disorders, aseptic meningitis, disorientation, depression, insomnia, nightmares, irritability, mental disorders;
From the sense organs:
often: vertigo;
very rarely: visual impairment (blurred vision, diplopia), hearing impairment, tinnitus, taste disorders;
From the urinary system:
very rarely: acute renal failure, hematuria, proteinuria, interstitial nephritis, nephrotic syndrome, papillary necrosis;
From the hematopoiesis:
very rarely: thrombocytopenia, leukopenia, hemolytic and aplastic anemia, agranulocytosis;
Allergic reactions:
very rarely: angioedema (including facial), anaphylactic / anaphylactoid reactions, including a marked decrease in blood pressure and shock;
From the cardiovascular system.
very rarely: palpitation, chest pain, increased blood pressure, vasculitis, heart failure, myocardial infarction;
From the respiratory system.
rarely: exacerbation of bronchial asthma (including dyspnea);
very rarely: pneumonitis;
From the skin:
often: skin rash;
rarely: urticaria;
very rarely: bullous rash, erythema, incl. multiform and Stevens-Johnson syndrome, Lyell's syndrome, exfoliative dermatitis, itching, hair loss, photosensitivity, purpura, incl. allergic.
Lansoprazole
From the digestive system:
often: constipation; infrequently: abdominal pain, diarrhea, nausea, dryness of the oral mucosa, dyspepsia, taste disorders, flatulence; very rarely: colitis, ulcerative colitis, candidiasis of the gastrointestinal tract, increase activity of "liver" enzymes, hyperbilirubinemia; rarely: jaundice, hepatitis;
From the nervous system:
often: headache;
infrequently: dizziness, anxiety, fear, confusion, depression, confusion;
From the respiratory system:
rarely: cough, pharyngitis, rhinitis, upper respiratory tract infection, flu-like syndrome;
On the part of the hematopoiesis system:
very rarely: leukopenia, thrombocytopenia, eosinophilia, pancytopenia or agranulocytosis;
Allergic reactions:
rarely: urticaria, angioedema, photosensitization; very rare: anaphylactic reactions;
Metabolic and nutritional disorders:
rarely: anorexia, increased appetite;
From the sense organs:
very rarely: visual impairment (blurred vision), tinnitus;
From the skin: often: skin rash;
rarely: purpura, petechiae, hair loss;
very rarely: toxic epidermal necrolysis, Stevens-Johnson syndrome, erythema multiforme;
From the musculoskeletal system:
rarely: pain in the joints, muscles and bones;
From the genitourinary system:
infrequently: increased concentration of creatinine.
very rarely: interstitial nephritis, renal failure, urogenital impaired, impotence, gynecomastia;
Other:
infrequently: feeling tired; very rarely: peripheral edema;