According to the World Health Organization (WHO)
undesirable reactions are classified according to their frequency of development as follows: very often (>1/10), often (>1/100, <1/10), infrequently (>1/1000, <1/100), rarely (>1/10000, <1/1000) and very rarely (<1/10000); frequency is unknown - according to available data, it was not possible to establish the frequency of occurrence.
From the gastrointestinal tract
often: nausea, vomiting, diarrhea, indigestion, abdominal pain, bloating, anorexia;
rarely: gastritis, vomiting with an admixture of blood, gastrointestinal bleeding, melena, stomach or bowel ulcers, possibly with complications (bleeding, perforation), frequent stools with a trace of blood, proctitis;
rarely: esophagitis, esophageal motility disorder, nonspecific hemorrhagic colitis, exacerbation of ulcerative colitis or Crohn's disease, constipation, stomatitis, glossitis, pancreatitis, exacerbation of hemorrhoids, intestinal adhesions.
From the nervous system
often: headache, dizziness;
rarely: drowsiness;
rarely: depression, anxiety, irritability, aseptic meningitis (more often in patients with systemic lupus erythematosus and other systemic connective tissue diseases), convulsions, weakness, disorientation, nightmarish dreams, memory impairment, tremor, cerebrovascular disorders, sensitivity disorders (including paresthesia).
From the sense organs
often: vertigo;
rarely: noise in the ears, hearing impairment, blurred vision, diplopia, a violation of taste sensations.
From the urinary system
rarely: acute renal failure, hematuria, proteinuria, nephrotic syndrome, interstitial nephritis, papillary necrosis.
On the part of the organs of hematopoiesis and lymphatic system
rarely: anemia (including hemolytic and aplastic anemia), leukopenia, thrombocytopenia (thrombocytopenic purpura), eosinophilia, agranulocytosis.
From the immune system
rarely: allergic reactions, hypersensitivity (including hives, angioedema, bronchospasm).
From the respiratory system
rarely: bronchial asthma.
From the side of the cardiovascular system
infrequently: myocardial infarction, chronic heart failure;
rarely: rise arterial pressure, vasculitis, a feeling of palpitations, extrasystole, chest pain cell.
From the skin and subcutaneous tissue
often: dermatitis (including contact dermatitis), erythema, eczema, pruritus, puffiness treated skin area, rash (papules, vesicles), peeling;
rarely: bullous dermatitis, pustular eruptions
rarely: photosensitization; generalized skin rash.
From the side are baked and bile ducts
often: increased activity of "liver" transaminases;
rarely: jaundice, liver damage;
rarely: hepatitis (possibly fulminant course), necrosis liver, cirrhosis, hepatorenal syndrome, hepatic failure.
Other
rarely: edema.