Diclofenac - instructions for use, dose, side effects, contraindications

Pharmacodynamics:A non-steroidal anti-inflammatory drug, a derivative of phenylacetic acid, has an anti-inflammatory and analgesic effect. Indiscriminately inhibiting cyclooxygenase 1 and cyclooxygenase 2, disrupts the metabolism of arachidonic acid, reduces the amount of prostaglandins in the inflammatory focus. With topical application reduces swelling and pain in inflammatory processes of non-infectious etiology.

Pharmacokinetics:The time of reaching the highest concentration in the moisture of the anterior chamber is 30 minutes after the installation, it penetrates into the anterior chamber of the eye; in the systemic circulation in therapeutically significant concentrations does not penetrate.

Indications:Inhibition of miosis during operations for cataracts; prevention and treatment of cystic maculopathy after surgical removal of cataracts; inflammatory process of non-infectious nature, conjunctivitis, keratoconjunctivitis, postoperative and post-traumatic uveitis, keratitis, corneal erosion.

Contraindications:Hypersensitivity to the components of the drug, acetylsalicylic acid.

Carefully:erosive-ulcerative processes of the gastrointestinal tract in the stage of exacerbation; diseases that cause blood clotting disorders (including hemophilia, prolonged bleeding time, a tendency to bleed); epithelial herpetic keratitis (including in the anamnesis); children and the elderly; bronchial asthma.

Pregnancy and lactation:There are no data on the use of the drug during pregnancy and lactation. If non-steroidal anti-inflammatory drugs are used in the third trimester of pregnancy, the risk of fetal circulation disorders may increase.Use in pregnant and lactating mothers is possible only for the purpose of the doctor in charge, if the expected therapeutic effect exceeds the risk of developing possible side effects.

Dosing and Administration:Buried in the conjunctival sac before the operation 1 drop 5 times for 3 hours, immediately after the operation - 1 drop 3 times, then - 1 drop 3-5 times a day for the time needed for treatment; other indications - 1 drop 4-5 times a day.

Side effects:Keratitis, increased intraocular pressure, deposition of deposits in the cornea, corneal edema, burning, blurred vision (immediately after instillation); corneal opacity (throat), iritis; allergic reactions: itching in the eyes, hyperemia, angioedema, facial sweating, fever, chills, photosensitivity, skin rash (mainly erythematous, urticaria), erythema multiforme exudative; nausea, vomiting.

Interaction:If necessary, can be used simultaneously with other eye drops, including those containing glucocorticosteroids. In this case, the break between applications should be at least 5 minutes to prevent the leaching of active substances with subsequent doses.

Special instructions:

The drug is not intended for subconjunctival administration or in the anterior chamber of the eye. After removing the contact lenses, instillation is done after 5 minutes.

If there is an infection or a threat of its development, local antibacterial treatment is prescribed at the same time.

The interval between the use of various drops is 5 minutes.

During the treatment period, care must be taken when driving vehicles and engaging in other potentially hazardous activities that require increased concentration and speed of psychomotor reactions.

Form release / dosage:

Eye drops 0.1%.

Packaging:

1.5 ml, 2 ml or 5 ml in a tube-dropper polymer. 1, 2, 4, 5 or 10 tubes with the instruction for the use of the drug in a pack of cardboard with partitions or without partitions.

5 ml or 10 ml into the bottle-dropper polymer.

1 or 2 vials of a dropper with instructions for the use of the drug in a pack of cardboard.

5 ml into glass bottles. 1 bottle complete with a lid-dropper in a sterile version and instructions for the use of the drug in a pack of cardboard.

Storage conditions:In the dark place at a temperature of no higher than 15 ° C. Protect from freezing. Keep out of the reach of children.

Shelf life:

2 years. Shelf life after the opening - 1 month.

Do not use after the expiry date, indicated on the package.

Terms of leave from pharmacies:On prescription

Registration number:LSR-005606/09

Date of registration:13.07.2009

The owner of the registration certificate:MOSCOW ENDOCRINE FACTORY, FSUE MOSCOW ENDOCRINE FACTORY, FSUE Russia

Manufacturer: & nbsp

MOSCOW ENDOCRINE FACTORY, FSUE Russia

Information update date: & nbsp23.02.2016

Illustrated instructions

Instructions

Diclofenac (Diclofenac)