Gastrointestinal tract:
more often 1% - abdominal pain, sensation of bloating, diarrhea, indigestion, nausea, constipation, flatulence, increased activity of "liver" enzymes, peptic ulcer with possible complications (bleeding, perforation), gastrointestinal bleeding;
less than 1% vomiting, jaundice, melena, the appearance of blood in the stool, esophagus damage, aphthous stomatitis, dry mouth and mucous membranes, hepatitis (possibly fulminant), liver necrosis, cirrhosis, hepatorenal syndrome, anorexia, pancreatitis, cholecystopancreatitis, colitis, gastritis, proctitis , a dysfunction of the liver, glossitis, nonspecific hemorrhagic colitis, exacerbation of ulcerative colitis or Crohn's disease.
Nervous system:
more often 1% - headache, dizziness;
less often 1% - sleep disturbance, drowsiness, depression, irritability ,. aseptic meningitis (more often in patients with systemic lupus erythematosus and other systemic connective tissue diseases), convulsions, weakness, disorientation, nightmares, feelings of fear, impaired sensation, incl. paresthesia, memory disorders, tremors, anxiety, cerebrovascular disorders, mental disorders.
Sense organs:
more often 1% - noise in ears;
less than 1% - blurred vision, diplopia, a taste disorder, reversible or irreversible hearing loss, scotoma.
Skin:
more often 1% - skin itching, skin rash;
less than 1% - Alopecia, hives, eczema, toxic dermatitis, multiforme
exudative erythema, incl. Stevens-Johnson syndrome, toxic epidermal
necrolysis (Lyell syndrome), increased photosensitivity, small-scale
hemorrhage.
Genitourinary system:
more often 1% - fluid retention;
less than 1% - Nephrotic syndrome, proteinuria, oliguria, hematuria, interstitial nephritis, papillary necrosis, acute renal failure, azotemia.
Hematopoiesis and the immune system:
less than 1% - Anemia (including hemolytic and aplastic anemia), leukopenia, thrombocytopenia, eosinophilia, agranulocytosis, thrombocytopenic purpura, worsening of the course of infectious processes (development of necrotizing fasciitis, pneumonia).
Respiratory system:
less than 1% - cough, bronchospasm, laryngeal edema, pneumonitis.
The cardiovascular system:
less than 1% - Increased blood pressure; congestive heart failure, extrasystole, chest pain, palpitations, myocardial infarction.
Allergic reactions:
less than 1% - Anaphylactoid reactions, anaphylactic shock (usually develops rapidly), swelling of the lips and tongue, allergic vasculitis.
Local reactions with intramuscular injection: burning, infiltration, aseptic necrosis, necrosis of adipose tissue.