When assessing the frequency of occurrence of various side effects, the following grades are used: often - 1-10%; sometimes -0.1-1.%; rarely - 0,01-0,1%; very rarely - less than 0.001%, including individual cases.
Allergic reactions:
rare- anaphylactic / anaphylactoid reactions, including marked lowering of blood pressure (BP) and shock;
very rarely - angioedema (including facial).
From the nervous system: often - headache, dizziness;
rarely - sleep disturbance, drowsiness;
very rarely - a violation of sensitivity, incl. paresthesia, memory disorders, tremor; convulsions, anxiety, cerebrovascular disorders, aseptic meningitis, disorientation, depression; insomnia, night "nightmares", irritability, mental disorders.
From the skin:
often - skin rash; rarely - hives;
very rarely - painful rashes, eczema, incl. multiform and Stevens-Johnson syndrome, Lyell's syndrome, exfoliative dermatitis, itching, hair loss, photosensitivity, purpura, incl. allergic.
From the urinary system:
Often - fluid retention;
very rarely - acute renal failure, hematuria, interstitial nephritis, nephrotic syndrome, papillary necrosis.
From the digestive system:
often - epigastric pain, nausea, vomiting, diarrhea, dyspepsia, flatulence, anorexia, increased activity of aminotransferases;
rarely - gastritis, proctitis, bleeding from the digestive tract (vomiting with blood, melena, diarrhea with a trace of blood), gastrointestinal ulcers (with or without bleeding or perforation), hepatitis, jaundice, impaired liver function;
very rarely - stomatitis, glossitis, esophagitis,diaphragm-like intestinal strictures (nonspecific hemorrhagic colitis, exacerbation of ulcerative colitis or Crohn's disease), constipation, pancreatitis, fulminant hepatitis.
From the hematopoiesis:
very rarely - thrombocytopenia, leukopenia, hemolytic and aplastic anemia, agranulocytosis.
From the respiratory system:
rarely - bronchial asthma (including dyspnea);
very rarely - pneumonitis.
From the sense organs:
often - vertigo;
very rarely - visual impairment (blurred vision, diplopia), hearing impairment, tinnitus, a violation of taste sensations.
From the cardiovascular system:
very rarely - palpitations, chest pain, increased blood pressure, vasculitis, heart failure, myocardial infarction.
If any of the side effects listed in the manual are aggravated, or if you notice any other side effects not listed in the instructions, inform the doctor about it.