Gastrointestinal tract:
more than 1% - abdominal pain, a feeling of bloating, diarrhea, nausea, constipation, flatulence, increased activity of "liver" enzymes, peptic ulcer with possible complications (bleeding, perforation), gastrointestinal bleeding;
less than 1% - vomiting, jaundice, melena, blood in stool, esophageal lesion, aphthous stomatitis, dryness of the mouth and the mucous membranes, hepatitis (possibly fulminant), hepatic necrosis, cirrhosis, hepatorenal syndrome, appetite change, pancreatitis, holetsistopankreatit, colitis .
Nervous system:
more often 1% - headache, dizziness;
less than 1% - sleep disturbance, drowsiness, depression, irritability, aseptic meningitis (more often in patients with systemic lupus erythematosus and other systemic connective tissue diseases), convulsions, weakness, disorientation, nightmares, fear.
Sense organs:
more often 1% - noise in the ears;
less than 1% - blurred vision, diplopia, a taste disorder, reversible or irreversible hearing loss, scotoma.
Skin:
more often 1% - skin itch, skin rash;
less than 1% - alopecia, urticaria, eczema, toxic dermatitis, multiform exudative erythema, incl. Stevens-Johnson syndrome, toxic epidermal necrolysis (Lyell syndrome), increased photosensitivity, small-point hemorrhages.
Genitourinary system:
more often 1% - fluid retention;
less than 1% - nephrotic syndrome, proteinuria, oliguria, hematuria, interstitial nephritis, papillary necrosis, acute renal failure, azotemia.
Hematopoiesis and the immune system:
less than 1% - anemia (including hemolytic and aplastic anemia), leukopenia, thrombocytopenia,
eosinophilia, agranulocytosis, thrombocytopenic purpura,deterioration of the course of infectious processes (development of necrotizing fasciitis).
Respiratory system:
less than 1% - cough, bronchospasm, laryngeal edema, pneumonitis.
The cardiovascular system:
less than 1% - increased blood pressure; congestive heart failure, extrasystole, chest pain.
Allergic reactions:
less often 1% - anaphylactoid reactions, anaphylactic shock (usually develops rapidly), swelling of the lips and tongue, allergic vasculitis.