Often - 1-10%; sometimes 0.1-1%; rarely - 0,01-0,1%; very rarely - less than 0,001%, including
isolated cases.
On the part of the digestive system:
often - epigastric pain, nausea, vomiting, diarrhea, dyspepsia, flatulence, anorexia, increased activity of aminotransferases;
rarely - gastritis, proctitis, bleeding from the gastrointestinal tract (vomiting with blood, melena, diarrhea with a trace of blood), ulcers of the gastrointestinal tract (with or without bleeding or perforation), hepatitis, jaundice, impaired liver function; very rarely - stomatitis, glossitis, esophagitis, diaphragm-like bowel patterns (nonspecific hemorrhagic colitis, exacerbation of ulcerative colitis or Crohn's disease), constipation, pancreatitis, fulminant hepatitis.
From the nervous system:
often - headache, dizziness; rarely - sleep disturbance, drowsiness;
very rarely - a violation of sensitivity, incl. paresthesia, memory disorders, tremors, convulsions, anxiety, cerebrovascular disorders, aseptic meningitis, disorientation, depression, insomnia, nightmares, irritability, mental disorders.
From the sense organs:
often - vertigo;
very rarely - visual impairment (blurred vision, diplopia), hearing impairment, tinnitus, a violation of taste sensations.
From the urinary system: often - fluid retention;
very rarely - acute renal failure, hematuria, interstitial nephritis, nephrotic syndrome, papillary necrosis.
From the organs of hematopoiesis and the immune system:
very rarely - thrombocytopenia, leukopenia, hemolytic and aplastic anemia, agranulocytosis.
Allergic reactions:
rarely anaphylactic / anaphylactoid reactions, including a marked decrease in blood pressure and shock; very rarely - angioedema (including face).
From the cardiovascular system:
very rarely - palpitations, chest pain, increased blood pressure, vasculitis, heart failure, myocardial infarction.
From the respiratory system:
rarely - bronchial asthma (including dyspnea); very rarely - pneumonitis.
From the skin:
often - skin rash; rarely - hives;
very rarely - painful rashes, eczema, incl. multiform and Stevens-Johnson syndrome, Lyell's syndrome, exfoliative dermatitis, itching, hair loss, photosensitivity, purpura, incl. allergic.