According to the World Health Organization (WHO), adverse reactions are classified according to their frequency of development as follows: very often (>1/10), often (>1/100, <1/10), infrequently (>1/1000, <1/100), rarely (>1/10000, <1/1000) and very rarely (<1/10000); frequency is unknown - according to available data, it was not possible to establish the frequency of occurrence.
From the gastrointestinal tract:
often: nausea, vomiting, diarrhea, indigestion, abdominal pain, flatulence, anorexia;
rarely: gastritis, vomiting with an admixture of blood, gastrointestinal bleeding, melena, stomach or bowel ulcers, possibly with complications (bleeding, perforation), frequent stools with a trace of blood, proctitis;
rarely: stomatitis, glossitis, esophageal motility disorder, nonspecific hemorrhagic colitis, exacerbation of ulcerative colitis or Crohn's disease, esophagitis, constipation, pancreatitis, exacerbation of hemorrhoids, intestinal adhesions.
From the nervous system:
often: headache, dizziness;
rarely: drowsiness;
rarely: a disorder of sensitivity (including paresthesia), memory impairment, tremor, convulsions, a sense of anxiety, a disorder of cerebral circulation, aseptic meningitis (more often in patients with systemic lupus erythematosus and other systemic connective tissue diseases), depression, irritability, weakness, disorientation, nightmares, insomnia.
From the sense organs:
often: vertigo;
rarely: noise in the ears, hearing impairment, blurred vision (blurred vision), diplopia, a violation of taste sensations.
From the urinary system:
rarely: acute renal failure, hematuria, proteinuria, nephrotic syndrome, interstitial nephritis, papillary necrosis.
On the part of the organs of hematopoiesis and lymphatic system:
rarely: anemia (including hemolytic and aplastic anemia), leukopenia, thrombocytopenia (thrombocytopenic purpura), eosinophilia, agranulocytosis.
From the immune system:
rarely: hypersensitivity, anaphylactic reactions (including
decrease in blood pressure (BP) and shock);
rarely: angioedema (including Quincke's edema).
From the respiratory system:
rarely: cough, bronchospasm, laryngeal edema;
rarely: pneumonitis.
From the side of the cardiovascular system:
infrequently: myocardial infarction, chronic heart failure,
heart palpitations and chest pain;
rarely: increased blood pressure, vasculitis, extrasystole.
From the skin:
often: skin itching, skin rash;
rarely: hives;
rarely: Bullous rash, eczema, erythema, polymorphic erythema,
epidermal necrolysis (Stevens-Johnson syndrome, Lyell syndrome),
exfoliative dermatitis, alopecia, photosensitivity reactions,
purple, purple Shenlaine-Henoch.
Co sides of the liver and bile ducts:
often: increased activity of "liver" transaminases;
rarely: jaundice, liver damage;
rarely: hepatitis (possibly fulminant), necrosis of the liver,
cirrhosis, hepatorenal syndrome, hepatic insufficiency.
Violations at the place of administration:
often: pain, compaction at the injection site;
rarely: edema, necrosis at the injection site.